The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400035 |
Resumo: | Salmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic conditions. The fumarate reductase (frdABCD), dimethyl sulfoxide (DMSO)-trimethylamine N-oxide (TMAO) reductase (dmsABC), and nitrate reductase (narGHIJ) operons in Salmonella Typhimurium (STM) encode enzymes involved in anaerobic respiration to the electron acceptors fumarate, DMSO, TMAO, and nitrate, respectively. They are regulated in response to nitrate and oxygen availability and changes in cell growth rate. In this study mortality rates of chickens challenged with mutants of Salmonella Gallinarum, which were defective in utilising anaerobic electron acceptors, were assessed in comparison to group of bird challenged with wild strain. The greatest degree of attenuation was observed with mutations affecting nitrate reductase (napA, narG) with additional attenuations induced by a mutation affecting fumarate reductase (frdA) and a double mutant (dmsA torC) affecting DMSO and TMAO reductase. |
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Brazilian Journal of Microbiology |
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The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickensSalmonella Gallinarumanaerobic genespoultrymutationsSalmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic conditions. The fumarate reductase (frdABCD), dimethyl sulfoxide (DMSO)-trimethylamine N-oxide (TMAO) reductase (dmsABC), and nitrate reductase (narGHIJ) operons in Salmonella Typhimurium (STM) encode enzymes involved in anaerobic respiration to the electron acceptors fumarate, DMSO, TMAO, and nitrate, respectively. They are regulated in response to nitrate and oxygen availability and changes in cell growth rate. In this study mortality rates of chickens challenged with mutants of Salmonella Gallinarum, which were defective in utilising anaerobic electron acceptors, were assessed in comparison to group of bird challenged with wild strain. The greatest degree of attenuation was observed with mutations affecting nitrate reductase (napA, narG) with additional attenuations induced by a mutation affecting fumarate reductase (frdA) and a double mutant (dmsA torC) affecting DMSO and TMAO reductase.Sociedade Brasileira de Microbiologia2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400035Brazilian Journal of Microbiology v.40 n.4 2009reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S1517-83822009000400035info:eu-repo/semantics/openAccessPaiva,J.B.Penha Filho,R.A.C.Pereira,E.A.Lemos,M.V.F.Barrow,P.A.Lovell,M.A.Berchieri Jr,A.eng2009-10-06T00:00:00Zoai:scielo:S1517-83822009000400035Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2009-10-06T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
title |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
spellingShingle |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens Paiva,J.B. Salmonella Gallinarum anaerobic genes poultry mutations |
title_short |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
title_full |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
title_fullStr |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
title_full_unstemmed |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
title_sort |
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens |
author |
Paiva,J.B. |
author_facet |
Paiva,J.B. Penha Filho,R.A.C. Pereira,E.A. Lemos,M.V.F. Barrow,P.A. Lovell,M.A. Berchieri Jr,A. |
author_role |
author |
author2 |
Penha Filho,R.A.C. Pereira,E.A. Lemos,M.V.F. Barrow,P.A. Lovell,M.A. Berchieri Jr,A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Paiva,J.B. Penha Filho,R.A.C. Pereira,E.A. Lemos,M.V.F. Barrow,P.A. Lovell,M.A. Berchieri Jr,A. |
dc.subject.por.fl_str_mv |
Salmonella Gallinarum anaerobic genes poultry mutations |
topic |
Salmonella Gallinarum anaerobic genes poultry mutations |
description |
Salmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic conditions. The fumarate reductase (frdABCD), dimethyl sulfoxide (DMSO)-trimethylamine N-oxide (TMAO) reductase (dmsABC), and nitrate reductase (narGHIJ) operons in Salmonella Typhimurium (STM) encode enzymes involved in anaerobic respiration to the electron acceptors fumarate, DMSO, TMAO, and nitrate, respectively. They are regulated in response to nitrate and oxygen availability and changes in cell growth rate. In this study mortality rates of chickens challenged with mutants of Salmonella Gallinarum, which were defective in utilising anaerobic electron acceptors, were assessed in comparison to group of bird challenged with wild strain. The greatest degree of attenuation was observed with mutations affecting nitrate reductase (napA, narG) with additional attenuations induced by a mutation affecting fumarate reductase (frdA) and a double mutant (dmsA torC) affecting DMSO and TMAO reductase. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400035 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1517-83822009000400035 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.40 n.4 2009 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122202664206336 |