Structure-biological activity relationship of synthetic trihydroxilated chalcones

Detalhes bibliográficos
Autor(a) principal: Devia,Cristina M.
Data de Publicação: 1998
Outros Autores: Pappano,Nora B., Debattista,Nora B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Microbiologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014
Resumo: The bacteriostatic activity of 2’,4’,2-trihydroxychalcone; 2’,4’,3-trihydroxychalcone and 2’,4’,4-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against Staphylococcus aureus ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against S. aureus were determined by the broth dilution method and the results obtained were compared to that of 2',4'-dihydroxychalcone. The sequence observed was: MIC 2’,4’,3-(OH)3 > MIC 2’,4’-(OH)2 > MIC 2’,4’,4-(OH)3 > > MIC 2’,4’,2-(OH)3. These results showed that the introduction of an electron donating group (-OH) in the aromatic B-ring causes an increase in bioactivity, and that the intensity of action depends on the position of the OH substitute.
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spelling Structure-biological activity relationship of synthetic trihydroxilated chalconesbacteriostatic activitystructure-activity relationshipflavonoidstrihydroxylated chalconesThe bacteriostatic activity of 2’,4’,2-trihydroxychalcone; 2’,4’,3-trihydroxychalcone and 2’,4’,4-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against Staphylococcus aureus ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against S. aureus were determined by the broth dilution method and the results obtained were compared to that of 2',4'-dihydroxychalcone. The sequence observed was: MIC 2’,4’,3-(OH)3 > MIC 2’,4’-(OH)2 > MIC 2’,4’,4-(OH)3 > > MIC 2’,4’,2-(OH)3. These results showed that the introduction of an electron donating group (-OH) in the aromatic B-ring causes an increase in bioactivity, and that the intensity of action depends on the position of the OH substitute.Sociedade Brasileira de Microbiologia1998-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014Revista de Microbiologia v.29 n.4 1998reponame:Revista de Microbiologiainstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1590/S0001-37141998000400014info:eu-repo/semantics/openAccessDevia,Cristina M.Pappano,Nora B.Debattista,Nora B.eng1999-05-27T00:00:00Zoai:scielo:S0001-37141998000400014Revistahttps://www.scielo.br/j/rm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||revmicro@icb.usp.br0001-37140001-3714opendoar:1999-05-27T00:00Revista de Microbiologia - Sociedade Brasileira de Microbiologia (SBM)false
dc.title.none.fl_str_mv Structure-biological activity relationship of synthetic trihydroxilated chalcones
title Structure-biological activity relationship of synthetic trihydroxilated chalcones
spellingShingle Structure-biological activity relationship of synthetic trihydroxilated chalcones
Devia,Cristina M.
bacteriostatic activity
structure-activity relationship
flavonoids
trihydroxylated chalcones
title_short Structure-biological activity relationship of synthetic trihydroxilated chalcones
title_full Structure-biological activity relationship of synthetic trihydroxilated chalcones
title_fullStr Structure-biological activity relationship of synthetic trihydroxilated chalcones
title_full_unstemmed Structure-biological activity relationship of synthetic trihydroxilated chalcones
title_sort Structure-biological activity relationship of synthetic trihydroxilated chalcones
author Devia,Cristina M.
author_facet Devia,Cristina M.
Pappano,Nora B.
Debattista,Nora B.
author_role author
author2 Pappano,Nora B.
Debattista,Nora B.
author2_role author
author
dc.contributor.author.fl_str_mv Devia,Cristina M.
Pappano,Nora B.
Debattista,Nora B.
dc.subject.por.fl_str_mv bacteriostatic activity
structure-activity relationship
flavonoids
trihydroxylated chalcones
topic bacteriostatic activity
structure-activity relationship
flavonoids
trihydroxylated chalcones
description The bacteriostatic activity of 2’,4’,2-trihydroxychalcone; 2’,4’,3-trihydroxychalcone and 2’,4’,4-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against Staphylococcus aureus ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against S. aureus were determined by the broth dilution method and the results obtained were compared to that of 2',4'-dihydroxychalcone. The sequence observed was: MIC 2’,4’,3-(OH)3 > MIC 2’,4’-(OH)2 > MIC 2’,4’,4-(OH)3 > > MIC 2’,4’,2-(OH)3. These results showed that the introduction of an electron donating group (-OH) in the aromatic B-ring causes an increase in bioactivity, and that the intensity of action depends on the position of the OH substitute.
publishDate 1998
dc.date.none.fl_str_mv 1998-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37141998000400014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv Revista de Microbiologia v.29 n.4 1998
reponame:Revista de Microbiologia
instname:Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM
instname_str Sociedade Brasileira de Microbiologia (SBM)
instacron_str SBM
institution SBM
reponame_str Revista de Microbiologia
collection Revista de Microbiologia
repository.name.fl_str_mv Revista de Microbiologia - Sociedade Brasileira de Microbiologia (SBM)
repository.mail.fl_str_mv bjm@sbmicrobiologia.org.br||revmicro@icb.usp.br
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