PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT

Detalhes bibliográficos
Autor(a) principal: Shen,Wei
Data de Publicação: 2021
Outros Autores: Liang,Xiaojun
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de medicina do esporte (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922021001000779
Resumo: ABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.
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spelling PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECTSportsBone Morphogenetic Protein 1Gene therapyABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.Sociedade Brasileira de Medicina do Exercício e do Esporte2021-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922021001000779Revista Brasileira de Medicina do Esporte v.27 n.8 2021reponame:Revista brasileira de medicina do esporte (Online)instname:Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)instacron:SBMEE10.1590/1517-8692202127082021_0360info:eu-repo/semantics/openAccessShen,WeiLiang,Xiaojuneng2021-11-25T00:00:00Zoai:scielo:S1517-86922021001000779Revistahttp://www.scielo.br/rbmeONGhttps://old.scielo.br/oai/scielo-oai.php||revista@medicinadoesporte.org.br1806-99401517-8692opendoar:2021-11-25T00:00Revista brasileira de medicina do esporte (Online) - Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)false
dc.title.none.fl_str_mv PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
title PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
spellingShingle PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
Shen,Wei
Sports
Bone Morphogenetic Protein 1
Gene therapy
title_short PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
title_full PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
title_fullStr PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
title_full_unstemmed PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
title_sort PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT
author Shen,Wei
author_facet Shen,Wei
Liang,Xiaojun
author_role author
author2 Liang,Xiaojun
author2_role author
dc.contributor.author.fl_str_mv Shen,Wei
Liang,Xiaojun
dc.subject.por.fl_str_mv Sports
Bone Morphogenetic Protein 1
Gene therapy
topic Sports
Bone Morphogenetic Protein 1
Gene therapy
description ABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922021001000779
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922021001000779
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1517-8692202127082021_0360
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina do Exercício e do Esporte
publisher.none.fl_str_mv Sociedade Brasileira de Medicina do Exercício e do Esporte
dc.source.none.fl_str_mv Revista Brasileira de Medicina do Esporte v.27 n.8 2021
reponame:Revista brasileira de medicina do esporte (Online)
instname:Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)
instacron:SBMEE
instname_str Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)
instacron_str SBMEE
institution SBMEE
reponame_str Revista brasileira de medicina do esporte (Online)
collection Revista brasileira de medicina do esporte (Online)
repository.name.fl_str_mv Revista brasileira de medicina do esporte (Online) - Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)
repository.mail.fl_str_mv ||revista@medicinadoesporte.org.br
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