Recombinant human erythropoietin in sports: a review

Detalhes bibliográficos
Autor(a) principal: Bento,Rafael Maia de Almeida
Data de Publicação: 2003
Outros Autores: Damasceno,Lúcia Menezes Pinto, Aquino Neto,Francisco Radler de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de medicina do esporte (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922003000300006
Resumo: Erythropoietin is an endogenous hormone of glicoproteic nature secreted by the kidneys and is the main regulator of the erythropoiesis. An alteration in its production generates a disturbance in the plasmatic concentration giving rise to several types of pathologies related to the hematopoietic system. The recombinant forms of erythropoietin have indiscriminately been used by athletes, mainly in endurance sports, by increasing the erythrocytes concentration, generating a better delivery of oxygen to the muscle tissue. The administration of recombinant erythropoietin was prohibited by the International Olympic Committee and its use considered as doping. This review has the intention to describe the physical, biological and pharmacokinetic properties of the endogenous erythropoietin, as well as its recombinant form, describing also its use in sports and the process of searching methodologies for its detection in doping control.
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spelling Recombinant human erythropoietin in sports: a reviewErythropoietinEpoetinPeptidic hormonesDoping controlErythropoietin is an endogenous hormone of glicoproteic nature secreted by the kidneys and is the main regulator of the erythropoiesis. An alteration in its production generates a disturbance in the plasmatic concentration giving rise to several types of pathologies related to the hematopoietic system. The recombinant forms of erythropoietin have indiscriminately been used by athletes, mainly in endurance sports, by increasing the erythrocytes concentration, generating a better delivery of oxygen to the muscle tissue. The administration of recombinant erythropoietin was prohibited by the International Olympic Committee and its use considered as doping. This review has the intention to describe the physical, biological and pharmacokinetic properties of the endogenous erythropoietin, as well as its recombinant form, describing also its use in sports and the process of searching methodologies for its detection in doping control.Sociedade Brasileira de Medicina do Exercício e do Esporte2003-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922003000300006Revista Brasileira de Medicina do Esporte v.9 n.3 2003reponame:Revista brasileira de medicina do esporte (Online)instname:Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)instacron:SBMEE10.1590/S1517-86922003000300006info:eu-repo/semantics/openAccessBento,Rafael Maia de AlmeidaDamasceno,Lúcia Menezes PintoAquino Neto,Francisco Radler deeng2015-12-07T00:00:00Zoai:scielo:S1517-86922003000300006Revistahttp://www.scielo.br/rbmeONGhttps://old.scielo.br/oai/scielo-oai.php||revista@medicinadoesporte.org.br1806-99401517-8692opendoar:2015-12-07T00:00Revista brasileira de medicina do esporte (Online) - Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)false
dc.title.none.fl_str_mv Recombinant human erythropoietin in sports: a review
title Recombinant human erythropoietin in sports: a review
spellingShingle Recombinant human erythropoietin in sports: a review
Bento,Rafael Maia de Almeida
Erythropoietin
Epoetin
Peptidic hormones
Doping control
title_short Recombinant human erythropoietin in sports: a review
title_full Recombinant human erythropoietin in sports: a review
title_fullStr Recombinant human erythropoietin in sports: a review
title_full_unstemmed Recombinant human erythropoietin in sports: a review
title_sort Recombinant human erythropoietin in sports: a review
author Bento,Rafael Maia de Almeida
author_facet Bento,Rafael Maia de Almeida
Damasceno,Lúcia Menezes Pinto
Aquino Neto,Francisco Radler de
author_role author
author2 Damasceno,Lúcia Menezes Pinto
Aquino Neto,Francisco Radler de
author2_role author
author
dc.contributor.author.fl_str_mv Bento,Rafael Maia de Almeida
Damasceno,Lúcia Menezes Pinto
Aquino Neto,Francisco Radler de
dc.subject.por.fl_str_mv Erythropoietin
Epoetin
Peptidic hormones
Doping control
topic Erythropoietin
Epoetin
Peptidic hormones
Doping control
description Erythropoietin is an endogenous hormone of glicoproteic nature secreted by the kidneys and is the main regulator of the erythropoiesis. An alteration in its production generates a disturbance in the plasmatic concentration giving rise to several types of pathologies related to the hematopoietic system. The recombinant forms of erythropoietin have indiscriminately been used by athletes, mainly in endurance sports, by increasing the erythrocytes concentration, generating a better delivery of oxygen to the muscle tissue. The administration of recombinant erythropoietin was prohibited by the International Olympic Committee and its use considered as doping. This review has the intention to describe the physical, biological and pharmacokinetic properties of the endogenous erythropoietin, as well as its recombinant form, describing also its use in sports and the process of searching methodologies for its detection in doping control.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922003000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922003000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1517-86922003000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina do Exercício e do Esporte
publisher.none.fl_str_mv Sociedade Brasileira de Medicina do Exercício e do Esporte
dc.source.none.fl_str_mv Revista Brasileira de Medicina do Esporte v.9 n.3 2003
reponame:Revista brasileira de medicina do esporte (Online)
instname:Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)
instacron:SBMEE
instname_str Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)
instacron_str SBMEE
institution SBMEE
reponame_str Revista brasileira de medicina do esporte (Online)
collection Revista brasileira de medicina do esporte (Online)
repository.name.fl_str_mv Revista brasileira de medicina do esporte (Online) - Sociedade Brasileira de Medicina do Exercício e do Esporte (SBMEE)
repository.mail.fl_str_mv ||revista@medicinadoesporte.org.br
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