Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485 |
Resumo: | Abstract INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland, and a biome where cryptococcosis has not yet been explored. |
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Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian PantanalCryptococcosisAidsCryptococcusMolecular typingCryptococcus neoformansCryptococcus gattiiAbstract INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland, and a biome where cryptococcosis has not yet been explored.Sociedade Brasileira de Medicina Tropical - SBMT2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485Revista da Sociedade Brasileira de Medicina Tropical v.51 n.4 2018reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0050-2018info:eu-repo/semantics/openAccessNunes,Joslaine de OliveiraTsujisaki,Rosianne Assis de SousaNunes,Maína de OliveiraLima,Gláucia Moreira EspíndolaPaniago,Anamaria Mello MirandaPontes,Elenir Rose Jardim CuryChang,Marilene Rodrigueseng2018-08-16T00:00:00Zoai:scielo:S0037-86822018000400485Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2018-08-16T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
title |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
spellingShingle |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal Nunes,Joslaine de Oliveira Cryptococcosis Aids Cryptococcus Molecular typing Cryptococcus neoformans Cryptococcus gattii |
title_short |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
title_full |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
title_fullStr |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
title_full_unstemmed |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
title_sort |
Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal |
author |
Nunes,Joslaine de Oliveira |
author_facet |
Nunes,Joslaine de Oliveira Tsujisaki,Rosianne Assis de Sousa Nunes,Maína de Oliveira Lima,Gláucia Moreira Espíndola Paniago,Anamaria Mello Miranda Pontes,Elenir Rose Jardim Cury Chang,Marilene Rodrigues |
author_role |
author |
author2 |
Tsujisaki,Rosianne Assis de Sousa Nunes,Maína de Oliveira Lima,Gláucia Moreira Espíndola Paniago,Anamaria Mello Miranda Pontes,Elenir Rose Jardim Cury Chang,Marilene Rodrigues |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nunes,Joslaine de Oliveira Tsujisaki,Rosianne Assis de Sousa Nunes,Maína de Oliveira Lima,Gláucia Moreira Espíndola Paniago,Anamaria Mello Miranda Pontes,Elenir Rose Jardim Cury Chang,Marilene Rodrigues |
dc.subject.por.fl_str_mv |
Cryptococcosis Aids Cryptococcus Molecular typing Cryptococcus neoformans Cryptococcus gattii |
topic |
Cryptococcosis Aids Cryptococcus Molecular typing Cryptococcus neoformans Cryptococcus gattii |
description |
Abstract INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland, and a biome where cryptococcosis has not yet been explored. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0050-2018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.51 n.4 2018 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122161188831232 |