Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal

Detalhes bibliográficos
Autor(a) principal: Nunes,Joslaine de Oliveira
Data de Publicação: 2018
Outros Autores: Tsujisaki,Rosianne Assis de Sousa, Nunes,Maína de Oliveira, Lima,Gláucia Moreira Espíndola, Paniago,Anamaria Mello Miranda, Pontes,Elenir Rose Jardim Cury, Chang,Marilene Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485
Resumo: Abstract INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland, and a biome where cryptococcosis has not yet been explored.
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spelling Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian PantanalCryptococcosisAidsCryptococcusMolecular typingCryptococcus neoformansCryptococcus gattiiAbstract INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland, and a biome where cryptococcosis has not yet been explored.Sociedade Brasileira de Medicina Tropical - SBMT2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485Revista da Sociedade Brasileira de Medicina Tropical v.51 n.4 2018reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0050-2018info:eu-repo/semantics/openAccessNunes,Joslaine de OliveiraTsujisaki,Rosianne Assis de SousaNunes,Maína de OliveiraLima,Gláucia Moreira EspíndolaPaniago,Anamaria Mello MirandaPontes,Elenir Rose Jardim CuryChang,Marilene Rodrigueseng2018-08-16T00:00:00Zoai:scielo:S0037-86822018000400485Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2018-08-16T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
title Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
spellingShingle Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
Nunes,Joslaine de Oliveira
Cryptococcosis
Aids
Cryptococcus
Molecular typing
Cryptococcus neoformans
Cryptococcus gattii
title_short Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
title_full Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
title_fullStr Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
title_full_unstemmed Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
title_sort Cryptococcal meningitis epidemiology: 17 years of experience in a State of the Brazilian Pantanal
author Nunes,Joslaine de Oliveira
author_facet Nunes,Joslaine de Oliveira
Tsujisaki,Rosianne Assis de Sousa
Nunes,Maína de Oliveira
Lima,Gláucia Moreira Espíndola
Paniago,Anamaria Mello Miranda
Pontes,Elenir Rose Jardim Cury
Chang,Marilene Rodrigues
author_role author
author2 Tsujisaki,Rosianne Assis de Sousa
Nunes,Maína de Oliveira
Lima,Gláucia Moreira Espíndola
Paniago,Anamaria Mello Miranda
Pontes,Elenir Rose Jardim Cury
Chang,Marilene Rodrigues
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes,Joslaine de Oliveira
Tsujisaki,Rosianne Assis de Sousa
Nunes,Maína de Oliveira
Lima,Gláucia Moreira Espíndola
Paniago,Anamaria Mello Miranda
Pontes,Elenir Rose Jardim Cury
Chang,Marilene Rodrigues
dc.subject.por.fl_str_mv Cryptococcosis
Aids
Cryptococcus
Molecular typing
Cryptococcus neoformans
Cryptococcus gattii
topic Cryptococcosis
Aids
Cryptococcus
Molecular typing
Cryptococcus neoformans
Cryptococcus gattii
description Abstract INTRODUCTION: This study aimed to describe cryptococcal meningitis (CM) cases and the associated demographic, clinical, and microbiological data obtained from cities in the State of Mato Grosso do Sul in the Midwestern region of Brazil. METHODS: The data from 129 patients with laboratory-confirmed CM admitted from 1997 to 2014 were retrospectively reviewed. The molecular types of Cryptococcus neoformans and Cryptococcus gattii isolated from cerebrospinal fluid were analyzed to determine their geographic distribution. RESULTS: The patients had a mean age of 37 years and consisted mostly of men (76.7%). Most of the Cryptococcus isolates were obtained from patients infected with human immunodeficiency virus (HIV) and included 105 (87.5%) and 5 (55.6%) isolates of C. neoformans and C. gattii complexes, respectively. A restriction fragment length polymorphism (RFLP) analysis of URA5 revealed that most of the isolates were C. neoformans molecular type VNI (89.1%), whereas the molecular types VGII (7%) and VNII (3.9%) were observed less frequently. Notably, 65% of the cases with a time from symptom onset to laboratory diagnosis of more than 60 days resulted in fatalities, and sequelae were observed among the patients who survived. CONCLUSIONS: The present study documents the occurrence of neurocryptococcosis, which is mainly caused by C. neoformans VNI, in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland, and a biome where cryptococcosis has not yet been explored.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400485
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/0037-8682-0050-2018
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.51 n.4 2018
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
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instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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