Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease

Detalhes bibliográficos
Autor(a) principal: Veiga,Joel Paulo Russomano
Data de Publicação: 1985
Outros Autores: Kimachi,Tatsuto, Lima Filho,Euclydes Custódio, Junqueira Jr,Luiz Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821985000200005
Resumo: The osmotic threshold for attaining the antidiuretic response to hypertonic saline infusion and Progressive dehydration was studied in 31 patients with the chronic form of Chagas' disease and 16 control patients. The chagasic patients exhibited enhanced osmoticsensitivity to the antidiuretic response. This was demonstrated by lower values of the increments in plasma osmolarity sufficient to induce a significant fall in water clearance, without alterations in the osmolar clearance or creatinine excretion. The time needed to attain the antidiuretic response was shorterfor chagasics in relation to normal subjects. The results suggest the existence of a disturbance in the fine control of osmoregulation in the chagasic patients. They are interpreted to be a consequence of the denervation in hypothalamic or extrahypothalamic areas that regulate the secretion of vasopressin in chronic Chagas' disease.
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spelling Increased osmotic sensitivity for antidiuretic response in chronic chagas' diseaseChagas' diseaseOsmotic thresholdAntidiuretic responseHypothalamic denervationThe osmotic threshold for attaining the antidiuretic response to hypertonic saline infusion and Progressive dehydration was studied in 31 patients with the chronic form of Chagas' disease and 16 control patients. The chagasic patients exhibited enhanced osmoticsensitivity to the antidiuretic response. This was demonstrated by lower values of the increments in plasma osmolarity sufficient to induce a significant fall in water clearance, without alterations in the osmolar clearance or creatinine excretion. The time needed to attain the antidiuretic response was shorterfor chagasics in relation to normal subjects. The results suggest the existence of a disturbance in the fine control of osmoregulation in the chagasic patients. They are interpreted to be a consequence of the denervation in hypothalamic or extrahypothalamic areas that regulate the secretion of vasopressin in chronic Chagas' disease.Sociedade Brasileira de Medicina Tropical - SBMT1985-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821985000200005Revista da Sociedade Brasileira de Medicina Tropical v.18 n.2 1985reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821985000200005info:eu-repo/semantics/openAccessVeiga,Joel Paulo RussomanoKimachi,TatsutoLima Filho,Euclydes CustódioJunqueira Jr,Luiz Fernandoeng2013-06-10T00:00:00Zoai:scielo:S0037-86821985000200005Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-06-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
title Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
spellingShingle Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
Veiga,Joel Paulo Russomano
Chagas' disease
Osmotic threshold
Antidiuretic response
Hypothalamic denervation
title_short Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
title_full Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
title_fullStr Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
title_full_unstemmed Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
title_sort Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease
author Veiga,Joel Paulo Russomano
author_facet Veiga,Joel Paulo Russomano
Kimachi,Tatsuto
Lima Filho,Euclydes Custódio
Junqueira Jr,Luiz Fernando
author_role author
author2 Kimachi,Tatsuto
Lima Filho,Euclydes Custódio
Junqueira Jr,Luiz Fernando
author2_role author
author
author
dc.contributor.author.fl_str_mv Veiga,Joel Paulo Russomano
Kimachi,Tatsuto
Lima Filho,Euclydes Custódio
Junqueira Jr,Luiz Fernando
dc.subject.por.fl_str_mv Chagas' disease
Osmotic threshold
Antidiuretic response
Hypothalamic denervation
topic Chagas' disease
Osmotic threshold
Antidiuretic response
Hypothalamic denervation
description The osmotic threshold for attaining the antidiuretic response to hypertonic saline infusion and Progressive dehydration was studied in 31 patients with the chronic form of Chagas' disease and 16 control patients. The chagasic patients exhibited enhanced osmoticsensitivity to the antidiuretic response. This was demonstrated by lower values of the increments in plasma osmolarity sufficient to induce a significant fall in water clearance, without alterations in the osmolar clearance or creatinine excretion. The time needed to attain the antidiuretic response was shorterfor chagasics in relation to normal subjects. The results suggest the existence of a disturbance in the fine control of osmoregulation in the chagasic patients. They are interpreted to be a consequence of the denervation in hypothalamic or extrahypothalamic areas that regulate the secretion of vasopressin in chronic Chagas' disease.
publishDate 1985
dc.date.none.fl_str_mv 1985-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821985000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821985000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86821985000200005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.18 n.2 1985
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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