Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release

Detalhes bibliográficos
Autor(a) principal: Ferreira,Thaís Furtado
Data de Publicação: 2015
Outros Autores: Matsuoka,Pollyanna da Fonseca Silva, Santos,Alcione Miranda dos, Caldas,Arlene de Jesus Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600724
Resumo: Abstract: INTRODUCTION: The treatment of individuals with active tuberculosis (TB) and the identification and treatment of latent tuberculosis infection (LTBI) contacts are the two most important strategies for the control of TB. The objective of this study was compare the performance of tuberculin skin testing (TST) with QuantiFERON-TB Gold In TUBE(r) in the diagnosis of LTBI in contacts of patients with active TB. METHODS: Cross-sectional analytical study with 60 contacts of patients with active pulmonary TB. A blood sample of each contact was taken for interferon-gamma release assay (IGRA) and subsequently performed the TST. A receiver operating characteristic curve was generated to assess the cutoff points and the sensitivity, predictive values, and accuracy were calculated. The agreement between IGRA and TST results was evaluated by Kappa coefficient. RESULTS: Here, 67.9% sensitivity, 84.4% specificity, 79.1% PPV, 75% NPV, and 76.7% accuracy were observed for the 5mm cutoff point. The prevalence of LTBI determined by TST and IGRA was 40% and 46.7%, respectively. CONCLUSIONS: Both QuantiFERON-TB Gold In TUBE(r) and TST showed good performance in LTBI diagnosis. The creation of specific diagnostic methods is necessary for the diagnosis of LTBI with higher sensitivity and specificity, preferably with low cost and not require a return visit for reading because with early treatment of latent forms can prevent active TB.
id SBMT-1_51191c388b5d0a7c766e286f028ec64f
oai_identifier_str oai:scielo:S0037-86822015000600724
network_acronym_str SBMT-1
network_name_str Revista da Sociedade Brasileira de Medicina Tropical
repository_id_str
spelling Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma releaseTuberculosisDiagnosisLatent tuberculosisInterferon-gammaAbstract: INTRODUCTION: The treatment of individuals with active tuberculosis (TB) and the identification and treatment of latent tuberculosis infection (LTBI) contacts are the two most important strategies for the control of TB. The objective of this study was compare the performance of tuberculin skin testing (TST) with QuantiFERON-TB Gold In TUBE(r) in the diagnosis of LTBI in contacts of patients with active TB. METHODS: Cross-sectional analytical study with 60 contacts of patients with active pulmonary TB. A blood sample of each contact was taken for interferon-gamma release assay (IGRA) and subsequently performed the TST. A receiver operating characteristic curve was generated to assess the cutoff points and the sensitivity, predictive values, and accuracy were calculated. The agreement between IGRA and TST results was evaluated by Kappa coefficient. RESULTS: Here, 67.9% sensitivity, 84.4% specificity, 79.1% PPV, 75% NPV, and 76.7% accuracy were observed for the 5mm cutoff point. The prevalence of LTBI determined by TST and IGRA was 40% and 46.7%, respectively. CONCLUSIONS: Both QuantiFERON-TB Gold In TUBE(r) and TST showed good performance in LTBI diagnosis. The creation of specific diagnostic methods is necessary for the diagnosis of LTBI with higher sensitivity and specificity, preferably with low cost and not require a return visit for reading because with early treatment of latent forms can prevent active TB.Sociedade Brasileira de Medicina Tropical - SBMT2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600724Revista da Sociedade Brasileira de Medicina Tropical v.48 n.6 2015reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0258-2015info:eu-repo/semantics/openAccessFerreira,Thaís FurtadoMatsuoka,Pollyanna da Fonseca SilvaSantos,Alcione Miranda dosCaldas,Arlene de Jesus Mendeseng2015-12-08T00:00:00Zoai:scielo:S0037-86822015000600724Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2015-12-08T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
title Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
spellingShingle Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
Ferreira,Thaís Furtado
Tuberculosis
Diagnosis
Latent tuberculosis
Interferon-gamma
title_short Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
title_full Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
title_fullStr Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
title_full_unstemmed Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
title_sort Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release
author Ferreira,Thaís Furtado
author_facet Ferreira,Thaís Furtado
Matsuoka,Pollyanna da Fonseca Silva
Santos,Alcione Miranda dos
Caldas,Arlene de Jesus Mendes
author_role author
author2 Matsuoka,Pollyanna da Fonseca Silva
Santos,Alcione Miranda dos
Caldas,Arlene de Jesus Mendes
author2_role author
author
author
dc.contributor.author.fl_str_mv Ferreira,Thaís Furtado
Matsuoka,Pollyanna da Fonseca Silva
Santos,Alcione Miranda dos
Caldas,Arlene de Jesus Mendes
dc.subject.por.fl_str_mv Tuberculosis
Diagnosis
Latent tuberculosis
Interferon-gamma
topic Tuberculosis
Diagnosis
Latent tuberculosis
Interferon-gamma
description Abstract: INTRODUCTION: The treatment of individuals with active tuberculosis (TB) and the identification and treatment of latent tuberculosis infection (LTBI) contacts are the two most important strategies for the control of TB. The objective of this study was compare the performance of tuberculin skin testing (TST) with QuantiFERON-TB Gold In TUBE(r) in the diagnosis of LTBI in contacts of patients with active TB. METHODS: Cross-sectional analytical study with 60 contacts of patients with active pulmonary TB. A blood sample of each contact was taken for interferon-gamma release assay (IGRA) and subsequently performed the TST. A receiver operating characteristic curve was generated to assess the cutoff points and the sensitivity, predictive values, and accuracy were calculated. The agreement between IGRA and TST results was evaluated by Kappa coefficient. RESULTS: Here, 67.9% sensitivity, 84.4% specificity, 79.1% PPV, 75% NPV, and 76.7% accuracy were observed for the 5mm cutoff point. The prevalence of LTBI determined by TST and IGRA was 40% and 46.7%, respectively. CONCLUSIONS: Both QuantiFERON-TB Gold In TUBE(r) and TST showed good performance in LTBI diagnosis. The creation of specific diagnostic methods is necessary for the diagnosis of LTBI with higher sensitivity and specificity, preferably with low cost and not require a return visit for reading because with early treatment of latent forms can prevent active TB.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600724
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600724
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0258-2015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.48 n.6 2015
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
_version_ 1752122160096215040