Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008 |
Resumo: | We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%), C (22%) and F (3%). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices. |
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Molecular epidemiology of HIV-1 in Rio Grande, RS, BrazilMolecular epidemiologyHIV subtypesModes of transmissionWe conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%), C (22%) and F (3%). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices.Sociedade Brasileira de Medicina Tropical - SBMT2002-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008Revista da Sociedade Brasileira de Medicina Tropical v.35 n.5 2002reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822002000500008info:eu-repo/semantics/openAccessMartínez,Ana Maria Barral deBarbosa,Edel FigueirêdoFerreira,Paulo César PelegrinoCardoso,Fabiola AdrieneSilveira,JussaraSassi,GabrielaSilva,Cláudio Moss daMendonça-Signorini,VeraAntunes,Carlos Maurício de Figueiredoeng2002-11-27T00:00:00Zoai:scielo:S0037-86822002000500008Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2002-11-27T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
title |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
spellingShingle |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil Martínez,Ana Maria Barral de Molecular epidemiology HIV subtypes Modes of transmission |
title_short |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
title_full |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
title_fullStr |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
title_full_unstemmed |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
title_sort |
Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
author |
Martínez,Ana Maria Barral de |
author_facet |
Martínez,Ana Maria Barral de Barbosa,Edel Figueirêdo Ferreira,Paulo César Pelegrino Cardoso,Fabiola Adriene Silveira,Jussara Sassi,Gabriela Silva,Cláudio Moss da Mendonça-Signorini,Vera Antunes,Carlos Maurício de Figueiredo |
author_role |
author |
author2 |
Barbosa,Edel Figueirêdo Ferreira,Paulo César Pelegrino Cardoso,Fabiola Adriene Silveira,Jussara Sassi,Gabriela Silva,Cláudio Moss da Mendonça-Signorini,Vera Antunes,Carlos Maurício de Figueiredo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Martínez,Ana Maria Barral de Barbosa,Edel Figueirêdo Ferreira,Paulo César Pelegrino Cardoso,Fabiola Adriene Silveira,Jussara Sassi,Gabriela Silva,Cláudio Moss da Mendonça-Signorini,Vera Antunes,Carlos Maurício de Figueiredo |
dc.subject.por.fl_str_mv |
Molecular epidemiology HIV subtypes Modes of transmission |
topic |
Molecular epidemiology HIV subtypes Modes of transmission |
description |
We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%), C (22%) and F (3%). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86822002000500008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.35 n.5 2002 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
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SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122151902642176 |