A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge

Detalhes bibliográficos
Autor(a) principal: Bal,Zumrut Sahbudak
Data de Publicação: 2017
Outros Autores: Yazici,Pinar, Sen,Semra, Eraslan,Cenk, Cavusoglu,Cengiz, Karapinar,Bulent, Vardar,Fadil
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000500709
Resumo: Abstract The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis. The altered immunological responses caused by anti-TNF treatment made the diagnosis challenging. Clinicians should bear this in mind and, if suspected, treatment should be initiated immediately.
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spelling A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challengeTuberculosisTumor necrosis factor antagonistJuvenile idiopathic arthritisAbstract The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis. The altered immunological responses caused by anti-TNF treatment made the diagnosis challenging. Clinicians should bear this in mind and, if suspected, treatment should be initiated immediately.Sociedade Brasileira de Medicina Tropical - SBMT2017-09-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000500709Revista da Sociedade Brasileira de Medicina Tropical v.50 n.5 2017reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0410-2016info:eu-repo/semantics/openAccessBal,Zumrut SahbudakYazici,PinarSen,SemraEraslan,CenkCavusoglu,CengizKarapinar,BulentVardar,Fadileng2018-01-10T00:00:00Zoai:scielo:S0037-86822017000500709Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2018-01-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
title A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
spellingShingle A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
Bal,Zumrut Sahbudak
Tuberculosis
Tumor necrosis factor antagonist
Juvenile idiopathic arthritis
title_short A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
title_full A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
title_fullStr A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
title_full_unstemmed A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
title_sort A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge
author Bal,Zumrut Sahbudak
author_facet Bal,Zumrut Sahbudak
Yazici,Pinar
Sen,Semra
Eraslan,Cenk
Cavusoglu,Cengiz
Karapinar,Bulent
Vardar,Fadil
author_role author
author2 Yazici,Pinar
Sen,Semra
Eraslan,Cenk
Cavusoglu,Cengiz
Karapinar,Bulent
Vardar,Fadil
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bal,Zumrut Sahbudak
Yazici,Pinar
Sen,Semra
Eraslan,Cenk
Cavusoglu,Cengiz
Karapinar,Bulent
Vardar,Fadil
dc.subject.por.fl_str_mv Tuberculosis
Tumor necrosis factor antagonist
Juvenile idiopathic arthritis
topic Tuberculosis
Tumor necrosis factor antagonist
Juvenile idiopathic arthritis
description Abstract The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis. The altered immunological responses caused by anti-TNF treatment made the diagnosis challenging. Clinicians should bear this in mind and, if suspected, treatment should be initiated immediately.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000500709
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000500709
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0410-2016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.50 n.5 2017
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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