Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822010000400010 |
Resumo: | INTRODUCTION: The objective of the study is to identify the main risk factors for death by New World visceral leishmaniasis and establish a coherent pathogenic substrate of severe disease based on clinical findings. METHODS: Seventy-six deceased inpatients and 320 successfully treated inpatients with VL were studied in a case control study. RESULTS: Bacterial infection and bleeding were mutually exclusive events leading to death. Five risk factors were unique for death by bacterial infection (malnutrition, pulmonary rales, severe anemia, severe absolute neutropenia and higher neutrophil count), while another six were unique for death by bleeding (jaundice, severe relative neutropenia, severe thrombocytopenia, liver injury, kidney failure, higher bone marrow parasite load). Bacterial infection, bleeding, severe anemia, diarrhea, dyspnea, edema, jaundice and bone marrow parasite load were the main syndromes of visceral leishmaniasis among successfully treated patients. CONCLUSIONS: The data support the idea that bacterial infections are due to immune paralysis. Broad organ and system involvement is plausibly due to the high production of proinflammatory cytokines, whose actions fit well with visceral leishmaniasis. The syndromes and causative mediators are typical of a slowly developing systemic inflammatory response syndrome. |
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Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control studyVisceral leishmaniasisKala-azarSevere inflammatory response syndromeAIDSBleedingINTRODUCTION: The objective of the study is to identify the main risk factors for death by New World visceral leishmaniasis and establish a coherent pathogenic substrate of severe disease based on clinical findings. METHODS: Seventy-six deceased inpatients and 320 successfully treated inpatients with VL were studied in a case control study. RESULTS: Bacterial infection and bleeding were mutually exclusive events leading to death. Five risk factors were unique for death by bacterial infection (malnutrition, pulmonary rales, severe anemia, severe absolute neutropenia and higher neutrophil count), while another six were unique for death by bleeding (jaundice, severe relative neutropenia, severe thrombocytopenia, liver injury, kidney failure, higher bone marrow parasite load). Bacterial infection, bleeding, severe anemia, diarrhea, dyspnea, edema, jaundice and bone marrow parasite load were the main syndromes of visceral leishmaniasis among successfully treated patients. CONCLUSIONS: The data support the idea that bacterial infections are due to immune paralysis. Broad organ and system involvement is plausibly due to the high production of proinflammatory cytokines, whose actions fit well with visceral leishmaniasis. The syndromes and causative mediators are typical of a slowly developing systemic inflammatory response syndrome.Sociedade Brasileira de Medicina Tropical - SBMT2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822010000400010Revista da Sociedade Brasileira de Medicina Tropical v.43 n.4 2010reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822010000400010info:eu-repo/semantics/openAccessCosta,Carlos Henrique NeryWerneck,Guilherme LoureiroCosta,Dorcas LamounierHolanda,Thiago AyresAguiar,Guilherme BrasileiroCarvalho,Aline SantosCavalcanti,Janaína CostaSantos,Loryenne Santoseng2010-08-17T00:00:00Zoai:scielo:S0037-86822010000400010Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2010-08-17T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
title |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
spellingShingle |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study Costa,Carlos Henrique Nery Visceral leishmaniasis Kala-azar Severe inflammatory response syndrome AIDS Bleeding |
title_short |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
title_full |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
title_fullStr |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
title_full_unstemmed |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
title_sort |
Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study |
author |
Costa,Carlos Henrique Nery |
author_facet |
Costa,Carlos Henrique Nery Werneck,Guilherme Loureiro Costa,Dorcas Lamounier Holanda,Thiago Ayres Aguiar,Guilherme Brasileiro Carvalho,Aline Santos Cavalcanti,Janaína Costa Santos,Loryenne Santos |
author_role |
author |
author2 |
Werneck,Guilherme Loureiro Costa,Dorcas Lamounier Holanda,Thiago Ayres Aguiar,Guilherme Brasileiro Carvalho,Aline Santos Cavalcanti,Janaína Costa Santos,Loryenne Santos |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa,Carlos Henrique Nery Werneck,Guilherme Loureiro Costa,Dorcas Lamounier Holanda,Thiago Ayres Aguiar,Guilherme Brasileiro Carvalho,Aline Santos Cavalcanti,Janaína Costa Santos,Loryenne Santos |
dc.subject.por.fl_str_mv |
Visceral leishmaniasis Kala-azar Severe inflammatory response syndrome AIDS Bleeding |
topic |
Visceral leishmaniasis Kala-azar Severe inflammatory response syndrome AIDS Bleeding |
description |
INTRODUCTION: The objective of the study is to identify the main risk factors for death by New World visceral leishmaniasis and establish a coherent pathogenic substrate of severe disease based on clinical findings. METHODS: Seventy-six deceased inpatients and 320 successfully treated inpatients with VL were studied in a case control study. RESULTS: Bacterial infection and bleeding were mutually exclusive events leading to death. Five risk factors were unique for death by bacterial infection (malnutrition, pulmonary rales, severe anemia, severe absolute neutropenia and higher neutrophil count), while another six were unique for death by bleeding (jaundice, severe relative neutropenia, severe thrombocytopenia, liver injury, kidney failure, higher bone marrow parasite load). Bacterial infection, bleeding, severe anemia, diarrhea, dyspnea, edema, jaundice and bone marrow parasite load were the main syndromes of visceral leishmaniasis among successfully treated patients. CONCLUSIONS: The data support the idea that bacterial infections are due to immune paralysis. Broad organ and system involvement is plausibly due to the high production of proinflammatory cytokines, whose actions fit well with visceral leishmaniasis. The syndromes and causative mediators are typical of a slowly developing systemic inflammatory response syndrome. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822010000400010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822010000400010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86822010000400010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.43 n.4 2010 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122155826413568 |