Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice

Detalhes bibliográficos
Autor(a) principal: Silva,Luciana M.
Data de Publicação: 2003
Outros Autores: Menezes,Rejane M. C., Oliveira,Sheilla Andrade de, Andrade,Zilton A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300004
Resumo: The sensitivity of the larval stages of Schistosoma mansoni to chemotherapy with praziquantel and oxamniquine was tested in mice during primary and secondary infections and after different intervals from cercarial exposure. Worm recovery by perfusion of the porto-mesenteric system, followed by counting and a morphometric study of the parasite, allowed the conclusion that the relative resistance of the larval stages of S. mansoni to schistosomicide drugs, demonstrated in primary infections, also persists when the host is already infected. This indicates that a therapeutic failure may result when an infected host is treated some time after being re-infected, because of the presence of migrating, drug-resistant, immature forms of the parasite.
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spelling Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of miceSchistosoma mansoniLarval stagesPraziquantelOxamniquineThe sensitivity of the larval stages of Schistosoma mansoni to chemotherapy with praziquantel and oxamniquine was tested in mice during primary and secondary infections and after different intervals from cercarial exposure. Worm recovery by perfusion of the porto-mesenteric system, followed by counting and a morphometric study of the parasite, allowed the conclusion that the relative resistance of the larval stages of S. mansoni to schistosomicide drugs, demonstrated in primary infections, also persists when the host is already infected. This indicates that a therapeutic failure may result when an infected host is treated some time after being re-infected, because of the presence of migrating, drug-resistant, immature forms of the parasite.Sociedade Brasileira de Medicina Tropical - SBMT2003-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300004Revista da Sociedade Brasileira de Medicina Tropical v.36 n.3 2003reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822003000300004info:eu-repo/semantics/openAccessSilva,Luciana M.Menezes,Rejane M. C.Oliveira,Sheilla Andrade deAndrade,Zilton A.eng2003-08-04T00:00:00Zoai:scielo:S0037-86822003000300004Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2003-08-04T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
title Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
spellingShingle Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
Silva,Luciana M.
Schistosoma mansoni
Larval stages
Praziquantel
Oxamniquine
title_short Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
title_full Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
title_fullStr Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
title_full_unstemmed Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
title_sort Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice
author Silva,Luciana M.
author_facet Silva,Luciana M.
Menezes,Rejane M. C.
Oliveira,Sheilla Andrade de
Andrade,Zilton A.
author_role author
author2 Menezes,Rejane M. C.
Oliveira,Sheilla Andrade de
Andrade,Zilton A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Luciana M.
Menezes,Rejane M. C.
Oliveira,Sheilla Andrade de
Andrade,Zilton A.
dc.subject.por.fl_str_mv Schistosoma mansoni
Larval stages
Praziquantel
Oxamniquine
topic Schistosoma mansoni
Larval stages
Praziquantel
Oxamniquine
description The sensitivity of the larval stages of Schistosoma mansoni to chemotherapy with praziquantel and oxamniquine was tested in mice during primary and secondary infections and after different intervals from cercarial exposure. Worm recovery by perfusion of the porto-mesenteric system, followed by counting and a morphometric study of the parasite, allowed the conclusion that the relative resistance of the larval stages of S. mansoni to schistosomicide drugs, demonstrated in primary infections, also persists when the host is already infected. This indicates that a therapeutic failure may result when an infected host is treated some time after being re-infected, because of the presence of migrating, drug-resistant, immature forms of the parasite.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822003000300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.36 n.3 2003
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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