Clinical variables associated with leprosy reactions and persistence of physical impairment
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600 |
Resumo: | Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized. |
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Clinical variables associated with leprosy reactions and persistence of physical impairmentLeprosyLeprosy reactionsPhysical impairmentCorticosteroid treatment Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized. Sociedade Brasileira de Medicina Tropical - SBMT2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0100-2013info:eu-repo/semantics/openAccessOliveira,Daniela Teles deSherlock,JonniaMelo,Enaldo Vieira deRollemberg,Karla Caroline VieiraPaixao,Telma Rodrigues Santos daAbuawad,Yasmin GamaSimon,Marise do ValeDuthie,MalcolmJesus,Amelia Ribeiro deeng2013-11-22T00:00:00Zoai:scielo:S0037-86822013000500600Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-11-22T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
spellingShingle |
Clinical variables associated with leprosy reactions and persistence of physical impairment Oliveira,Daniela Teles de Leprosy Leprosy reactions Physical impairment Corticosteroid treatment |
title_short |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_full |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_fullStr |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_full_unstemmed |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
title_sort |
Clinical variables associated with leprosy reactions and persistence of physical impairment |
author |
Oliveira,Daniela Teles de |
author_facet |
Oliveira,Daniela Teles de Sherlock,Jonnia Melo,Enaldo Vieira de Rollemberg,Karla Caroline Vieira Paixao,Telma Rodrigues Santos da Abuawad,Yasmin Gama Simon,Marise do Vale Duthie,Malcolm Jesus,Amelia Ribeiro de |
author_role |
author |
author2 |
Sherlock,Jonnia Melo,Enaldo Vieira de Rollemberg,Karla Caroline Vieira Paixao,Telma Rodrigues Santos da Abuawad,Yasmin Gama Simon,Marise do Vale Duthie,Malcolm Jesus,Amelia Ribeiro de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Daniela Teles de Sherlock,Jonnia Melo,Enaldo Vieira de Rollemberg,Karla Caroline Vieira Paixao,Telma Rodrigues Santos da Abuawad,Yasmin Gama Simon,Marise do Vale Duthie,Malcolm Jesus,Amelia Ribeiro de |
dc.subject.por.fl_str_mv |
Leprosy Leprosy reactions Physical impairment Corticosteroid treatment |
topic |
Leprosy Leprosy reactions Physical impairment Corticosteroid treatment |
description |
Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0100-2013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122159119990784 |