Clinical variables associated with leprosy reactions and persistence of physical impairment

Detalhes bibliográficos
Autor(a) principal: Oliveira,Daniela Teles de
Data de Publicação: 2013
Outros Autores: Sherlock,Jonnia, Melo,Enaldo Vieira de, Rollemberg,Karla Caroline Vieira, Paixao,Telma Rodrigues Santos da, Abuawad,Yasmin Gama, Simon,Marise do Vale, Duthie,Malcolm, Jesus,Amelia Ribeiro de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600
Resumo: Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized.
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spelling Clinical variables associated with leprosy reactions and persistence of physical impairmentLeprosyLeprosy reactionsPhysical impairmentCorticosteroid treatment Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized. Sociedade Brasileira de Medicina Tropical - SBMT2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0100-2013info:eu-repo/semantics/openAccessOliveira,Daniela Teles deSherlock,JonniaMelo,Enaldo Vieira deRollemberg,Karla Caroline VieiraPaixao,Telma Rodrigues Santos daAbuawad,Yasmin GamaSimon,Marise do ValeDuthie,MalcolmJesus,Amelia Ribeiro deeng2013-11-22T00:00:00Zoai:scielo:S0037-86822013000500600Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-11-22T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Clinical variables associated with leprosy reactions and persistence of physical impairment
title Clinical variables associated with leprosy reactions and persistence of physical impairment
spellingShingle Clinical variables associated with leprosy reactions and persistence of physical impairment
Oliveira,Daniela Teles de
Leprosy
Leprosy reactions
Physical impairment
Corticosteroid treatment
title_short Clinical variables associated with leprosy reactions and persistence of physical impairment
title_full Clinical variables associated with leprosy reactions and persistence of physical impairment
title_fullStr Clinical variables associated with leprosy reactions and persistence of physical impairment
title_full_unstemmed Clinical variables associated with leprosy reactions and persistence of physical impairment
title_sort Clinical variables associated with leprosy reactions and persistence of physical impairment
author Oliveira,Daniela Teles de
author_facet Oliveira,Daniela Teles de
Sherlock,Jonnia
Melo,Enaldo Vieira de
Rollemberg,Karla Caroline Vieira
Paixao,Telma Rodrigues Santos da
Abuawad,Yasmin Gama
Simon,Marise do Vale
Duthie,Malcolm
Jesus,Amelia Ribeiro de
author_role author
author2 Sherlock,Jonnia
Melo,Enaldo Vieira de
Rollemberg,Karla Caroline Vieira
Paixao,Telma Rodrigues Santos da
Abuawad,Yasmin Gama
Simon,Marise do Vale
Duthie,Malcolm
Jesus,Amelia Ribeiro de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Daniela Teles de
Sherlock,Jonnia
Melo,Enaldo Vieira de
Rollemberg,Karla Caroline Vieira
Paixao,Telma Rodrigues Santos da
Abuawad,Yasmin Gama
Simon,Marise do Vale
Duthie,Malcolm
Jesus,Amelia Ribeiro de
dc.subject.por.fl_str_mv Leprosy
Leprosy reactions
Physical impairment
Corticosteroid treatment
topic Leprosy
Leprosy reactions
Physical impairment
Corticosteroid treatment
description Introduction Leprosy is a chronic disease that affects skin and peripheral nerves. Disease complications include reactional episodes and physical impairment. One World Health Organization (WHO) goal of leprosy programs is to decrease the number of grade 2 impairment diagnoses by 2015. This study aims to evaluate clinical factors associated with the occurrence of leprosy reactions and physical impairment in leprosy patients. Methods We conducted a retrospective study of data from medical records of patients followed in two important centers for the treatment of leprosy in Aracaju, Sergipe, Brazil, from 2005 to 2011. We used the chi-square test to analyze associations between the following categorical variables: gender, age, operational classification, clinical forms, leprosy reactions, corticosteroid treatment, and physical impairment at the diagnosis and after cure. Clinical variables associated with multibacillary leprosy and/or reactional episodes and the presence of any grade of physical impairment after cure were evaluated using the logistic regression model. Results We found that men were more affected by multibacillary forms, reactional episodes, and grade 2 physical impairment at diagnosis. Leprosy reactions were detected in a total of 40% of patients and all were treated with corticosteroids. However, physical impairment was observed in 29.8% of the patients analyzed at the end of the treatment and our multivariate analysis associated a low dose and short period of corticosteroid treatment with persistence of physical impairments. Conclusions Physical impairment should receive an increased attention before and after treatment, and adequate treatment should be emphasized.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0100-2013
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
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instacron_str SBMT
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reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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