The role of spleen macrophages in malaria: an ultrastructural study
Autor(a) principal: | |
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Data de Publicação: | 1984 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821984000100007 |
Resumo: | An electronmicroscopy study of the spleen from mice infected with Plasmodium berghei was carried out to investigate the types ofcells in volved in the removal of parasites from the blood, and the mechanisms by which this occurs. Macrophages, particularly from the red pulp and the marginal zone of the spleen, constituted the most important population of phagocytic cells in the spleen. At the height ofparasitaemia, macrophages in the periphery of the white pulp, especially in the mantle zone of secondary follicles, were also found to participate in phagocytosis, although to a limited extent. Our fingings suggest that phagocytosis of free parasites or parasitized erythrocytes in the spleen is an important mechanism of clearance of parasites from the circulation. Parasites removed from the erythrocytes when these cells cross the interendothelial slits are further phagocytosed by neighbouring macrophages. Evidence is presented suggesting that spleen macrophages may act against the parasite through a process of cytotoxicity. |
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The role of spleen macrophages in malaria: an ultrastructural studyMalariaPlasmodium bergheiBALB/c miceSpleenMacrophagesPhagocytosisCytotoxicityAn electronmicroscopy study of the spleen from mice infected with Plasmodium berghei was carried out to investigate the types ofcells in volved in the removal of parasites from the blood, and the mechanisms by which this occurs. Macrophages, particularly from the red pulp and the marginal zone of the spleen, constituted the most important population of phagocytic cells in the spleen. At the height ofparasitaemia, macrophages in the periphery of the white pulp, especially in the mantle zone of secondary follicles, were also found to participate in phagocytosis, although to a limited extent. Our fingings suggest that phagocytosis of free parasites or parasitized erythrocytes in the spleen is an important mechanism of clearance of parasites from the circulation. Parasites removed from the erythrocytes when these cells cross the interendothelial slits are further phagocytosed by neighbouring macrophages. Evidence is presented suggesting that spleen macrophages may act against the parasite through a process of cytotoxicity.Sociedade Brasileira de Medicina Tropical - SBMT1984-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821984000100007Revista da Sociedade Brasileira de Medicina Tropical v.17 n.1 1984reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821984000100007info:eu-repo/semantics/openAccessTosta,Carlos EduardoRuiz,GretaWedderburn,Ninaeng2013-06-10T00:00:00Zoai:scielo:S0037-86821984000100007Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-06-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
The role of spleen macrophages in malaria: an ultrastructural study |
title |
The role of spleen macrophages in malaria: an ultrastructural study |
spellingShingle |
The role of spleen macrophages in malaria: an ultrastructural study Tosta,Carlos Eduardo Malaria Plasmodium berghei BALB/c mice Spleen Macrophages Phagocytosis Cytotoxicity |
title_short |
The role of spleen macrophages in malaria: an ultrastructural study |
title_full |
The role of spleen macrophages in malaria: an ultrastructural study |
title_fullStr |
The role of spleen macrophages in malaria: an ultrastructural study |
title_full_unstemmed |
The role of spleen macrophages in malaria: an ultrastructural study |
title_sort |
The role of spleen macrophages in malaria: an ultrastructural study |
author |
Tosta,Carlos Eduardo |
author_facet |
Tosta,Carlos Eduardo Ruiz,Greta Wedderburn,Nina |
author_role |
author |
author2 |
Ruiz,Greta Wedderburn,Nina |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Tosta,Carlos Eduardo Ruiz,Greta Wedderburn,Nina |
dc.subject.por.fl_str_mv |
Malaria Plasmodium berghei BALB/c mice Spleen Macrophages Phagocytosis Cytotoxicity |
topic |
Malaria Plasmodium berghei BALB/c mice Spleen Macrophages Phagocytosis Cytotoxicity |
description |
An electronmicroscopy study of the spleen from mice infected with Plasmodium berghei was carried out to investigate the types ofcells in volved in the removal of parasites from the blood, and the mechanisms by which this occurs. Macrophages, particularly from the red pulp and the marginal zone of the spleen, constituted the most important population of phagocytic cells in the spleen. At the height ofparasitaemia, macrophages in the periphery of the white pulp, especially in the mantle zone of secondary follicles, were also found to participate in phagocytosis, although to a limited extent. Our fingings suggest that phagocytosis of free parasites or parasitized erythrocytes in the spleen is an important mechanism of clearance of parasites from the circulation. Parasites removed from the erythrocytes when these cells cross the interendothelial slits are further phagocytosed by neighbouring macrophages. Evidence is presented suggesting that spleen macrophages may act against the parasite through a process of cytotoxicity. |
publishDate |
1984 |
dc.date.none.fl_str_mv |
1984-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821984000100007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821984000100007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86821984000100007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.17 n.1 1984 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122148166565888 |