Features to validate cerebral toxoplasmosis
Main Author: | |
---|---|
Publication Date: | 2013 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Revista da Sociedade Brasileira de Medicina Tropical |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373 |
Summary: | Introduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii. |
id |
SBMT-1_c7e1116f9e42903ac9155eeb2d1058dc |
---|---|
oai_identifier_str |
oai:scielo:S0037-86822013000300373 |
network_acronym_str |
SBMT-1 |
network_name_str |
Revista da Sociedade Brasileira de Medicina Tropical |
repository_id_str |
|
spelling |
Features to validate cerebral toxoplasmosisAIDSCerebral toxoplasmosisDiagnosis Introduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii. Sociedade Brasileira de Medicina Tropical - SBMT2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373Revista da Sociedade Brasileira de Medicina Tropical v.46 n.3 2013reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-1202-2013info:eu-repo/semantics/openAccessCorreia,Carolina da CunhaMelo,Heloisa Ramos LacerdaCosta,Vlaudia Maria AssisBrainer,Alessandra Mertenseng2013-07-05T00:00:00Zoai:scielo:S0037-86822013000300373Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-07-05T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Features to validate cerebral toxoplasmosis |
title |
Features to validate cerebral toxoplasmosis |
spellingShingle |
Features to validate cerebral toxoplasmosis Correia,Carolina da Cunha AIDS Cerebral toxoplasmosis Diagnosis |
title_short |
Features to validate cerebral toxoplasmosis |
title_full |
Features to validate cerebral toxoplasmosis |
title_fullStr |
Features to validate cerebral toxoplasmosis |
title_full_unstemmed |
Features to validate cerebral toxoplasmosis |
title_sort |
Features to validate cerebral toxoplasmosis |
author |
Correia,Carolina da Cunha |
author_facet |
Correia,Carolina da Cunha Melo,Heloisa Ramos Lacerda Costa,Vlaudia Maria Assis Brainer,Alessandra Mertens |
author_role |
author |
author2 |
Melo,Heloisa Ramos Lacerda Costa,Vlaudia Maria Assis Brainer,Alessandra Mertens |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Correia,Carolina da Cunha Melo,Heloisa Ramos Lacerda Costa,Vlaudia Maria Assis Brainer,Alessandra Mertens |
dc.subject.por.fl_str_mv |
AIDS Cerebral toxoplasmosis Diagnosis |
topic |
AIDS Cerebral toxoplasmosis Diagnosis |
description |
Introduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300373 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-1202-2013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.46 n.3 2013 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122158715240448 |