Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation

Detalhes bibliográficos
Autor(a) principal: Chalela,Claudia Marcela
Data de Publicação: 2021
Outros Autores: Peña,Angela Maria, Roa,Angela Maria, Reyes,David L., Rueda,Jennifer Paola, Salazar,Luis Antonio, Rosales,Manuel, Gomez,Edgar David, Bernal,Edgar Augusto, Melo,Claudia Lucia Sossa
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100705
Resumo: Abstract Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
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spelling Reactivation of Chagas disease after autologous hematopoietic stem cell transplantationStem cell transplantationChagas diseaseTrypanosoma cruziAbstract Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.Sociedade Brasileira de Medicina Tropical - SBMT2021-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100705Revista da Sociedade Brasileira de Medicina Tropical v.54 2021reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0143-2020info:eu-repo/semantics/openAccessChalela,Claudia MarcelaPeña,Angela MariaRoa,Angela MariaReyes,David L.Rueda,Jennifer PaolaSalazar,Luis AntonioRosales,ManuelGomez,Edgar DavidBernal,Edgar AugustoMelo,Claudia Lucia Sossaeng2021-01-19T00:00:00Zoai:scielo:S0037-86822021000100705Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2021-01-19T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
title Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
spellingShingle Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
Chalela,Claudia Marcela
Stem cell transplantation
Chagas disease
Trypanosoma cruzi
title_short Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
title_full Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
title_fullStr Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
title_full_unstemmed Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
title_sort Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
author Chalela,Claudia Marcela
author_facet Chalela,Claudia Marcela
Peña,Angela Maria
Roa,Angela Maria
Reyes,David L.
Rueda,Jennifer Paola
Salazar,Luis Antonio
Rosales,Manuel
Gomez,Edgar David
Bernal,Edgar Augusto
Melo,Claudia Lucia Sossa
author_role author
author2 Peña,Angela Maria
Roa,Angela Maria
Reyes,David L.
Rueda,Jennifer Paola
Salazar,Luis Antonio
Rosales,Manuel
Gomez,Edgar David
Bernal,Edgar Augusto
Melo,Claudia Lucia Sossa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chalela,Claudia Marcela
Peña,Angela Maria
Roa,Angela Maria
Reyes,David L.
Rueda,Jennifer Paola
Salazar,Luis Antonio
Rosales,Manuel
Gomez,Edgar David
Bernal,Edgar Augusto
Melo,Claudia Lucia Sossa
dc.subject.por.fl_str_mv Stem cell transplantation
Chagas disease
Trypanosoma cruzi
topic Stem cell transplantation
Chagas disease
Trypanosoma cruzi
description Abstract Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100705
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100705
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0143-2020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.54 2021
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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