American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis resistant to meglumine antimoniate, but with good response to pentamidine: a case report

• Autor(a) principal: Pimentel,Maria Inês Fernandes
• Data de Publicação: 2011
• Outros Autores: Baptista,Cibele, Rubin,Évelyn Figueiredo, Vasconcellos,Érica de Camargo Ferreira e, Lyra,Marcelo Rosandiski, Salgueiro,Mariza de Matos, Saheki,Maurício Naoto, Rosalino,Cláudia Maria Valete, Madeira,Maria de Fátima, Silva,Aline Fagundes da, Confort,Eliame Mouta, Schubach,Armando de Oliveira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000200026
• topic: Cutaneous leishmaniasis; Therapeutics; Drug resistance

This is a case report of a Brazilian soldier with cutaneous leishmaniasis. The lesion relapsed following two systemic treatments with meglumine antimoniate. The patient was treated with amphotericin B, which was interrupted due to poor tolerance. Following isolation of Leishmania sp., six intralesional infiltrations of meglumine antimoniate resulted in no response. Leishmania sp promastigotes were again isolated. The patient was submitted to intramuscular 4mg/kg pentamidine. Parasites from the first and second biopsies were identified as Leishmania (Viannia) braziliensis; those isolated from the first biopsy were more sensitive to meglumine antimoniate in vitro than those isolated from the second biopsy. No relapse was observed.