Evaluation of platelet number and function and fibrinogen level in patients bitten by snakes of the Bothrops genus

• Autor(a) principal: Luan,Fábio Cardoso
• Data de Publicação: 1995
• Outros Autores: Thomazini,Izolete Aparecida, Carvalho,Iracema, Carreira,Delane Mercedes Gonçalves, Cassinelli,Valter José, Pereira,Paulo Câmara Marques, Barraviera,Benedito
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000100004
• topic: Platelet function; Fibrinogen; FDP; Bothrops

Platelet function and plasma fibrinogen levels were evaluated in 14 patients, 10 males and 4females, aged 13-59years bitten by Bothrops genus snakes. There was a statistical difference (p < 0.05) among plasma fibrinogen levels evaluated 24 and 48 hours after envenomation. There was a tendency towards normalization after 48 hours of treatment. The low platelet number was clear in 24-48 hour evaluations with a tendency towards normalization after 48 hours of treatment (p<0.05). Fibrinogen levels and fibrin degradation product (FDP) levels appeared to be altered in 83.33% of patients evaluated. The authors suggest that platelet hypoaggregation is related to decreased fibrinogen and increased FDP levels.</