Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus

Detalhes bibliográficos
Autor(a) principal: Tavares,Fernando N.
Data de Publicação: 2005
Outros Autores: Gonçalves,Patricia L., Porto,Simone A.C., Pereira,Fausto E.L., Ribeiro-Rodrigues,Rodrigo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600001
Resumo: The aim of this investigation was to determine nitric oxide metabolite levels in saliva samples from hepatitis C virus-positive patients in an attempt to test the hypothesis if increased levels of nitric oxide metabolites correlates with the presence of HCV-RNA in saliva. Saliva of 39 HCV-positive patients and 13 HCV-negative patients, without clinical or laboratorial evidence of liver disease were tested for nitric oxide metabolites. HCV-RNA was detected in serum and saliva by a RT-PCR method and nitric oxide level was determined by evaluation of its stable degradation products, nitrate and nitrite. No differences were found between the concentration of nitrite in saliva from HCV patients and controls, in despite of the presence or not of HCV RNA in saliva. Patients with HCV and cirrhosis had higher concentrations of nitrite but not significantly different from the control group or the groups of anti-HCV patients without cirrhosis. Increased levels of nitrite were not detected in anti-HCV positive patients, an indirect indication that chronic sialoadenitis are infrequent in these patients or occurs with low intensity not sufficient to increase nitric oxide metabolite levels in saliva.
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spelling Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virusHepatitis CSalivaNitric oxideSialoadenitisThe aim of this investigation was to determine nitric oxide metabolite levels in saliva samples from hepatitis C virus-positive patients in an attempt to test the hypothesis if increased levels of nitric oxide metabolites correlates with the presence of HCV-RNA in saliva. Saliva of 39 HCV-positive patients and 13 HCV-negative patients, without clinical or laboratorial evidence of liver disease were tested for nitric oxide metabolites. HCV-RNA was detected in serum and saliva by a RT-PCR method and nitric oxide level was determined by evaluation of its stable degradation products, nitrate and nitrite. No differences were found between the concentration of nitrite in saliva from HCV patients and controls, in despite of the presence or not of HCV RNA in saliva. Patients with HCV and cirrhosis had higher concentrations of nitrite but not significantly different from the control group or the groups of anti-HCV patients without cirrhosis. Increased levels of nitrite were not detected in anti-HCV positive patients, an indirect indication that chronic sialoadenitis are infrequent in these patients or occurs with low intensity not sufficient to increase nitric oxide metabolite levels in saliva.Sociedade Brasileira de Medicina Tropical - SBMT2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600001Revista da Sociedade Brasileira de Medicina Tropical v.38 n.6 2005reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822005000600001info:eu-repo/semantics/openAccessTavares,Fernando N.Gonçalves,Patricia L.Porto,Simone A.C.Pereira,Fausto E.L.Ribeiro-Rodrigues,Rodrigoeng2006-01-04T00:00:00Zoai:scielo:S0037-86822005000600001Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2006-01-04T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
title Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
spellingShingle Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
Tavares,Fernando N.
Hepatitis C
Saliva
Nitric oxide
Sialoadenitis
title_short Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
title_full Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
title_fullStr Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
title_full_unstemmed Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
title_sort Nitric oxide levels are not changed in saliva of patients infected with hepatitis C virus
author Tavares,Fernando N.
author_facet Tavares,Fernando N.
Gonçalves,Patricia L.
Porto,Simone A.C.
Pereira,Fausto E.L.
Ribeiro-Rodrigues,Rodrigo
author_role author
author2 Gonçalves,Patricia L.
Porto,Simone A.C.
Pereira,Fausto E.L.
Ribeiro-Rodrigues,Rodrigo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Tavares,Fernando N.
Gonçalves,Patricia L.
Porto,Simone A.C.
Pereira,Fausto E.L.
Ribeiro-Rodrigues,Rodrigo
dc.subject.por.fl_str_mv Hepatitis C
Saliva
Nitric oxide
Sialoadenitis
topic Hepatitis C
Saliva
Nitric oxide
Sialoadenitis
description The aim of this investigation was to determine nitric oxide metabolite levels in saliva samples from hepatitis C virus-positive patients in an attempt to test the hypothesis if increased levels of nitric oxide metabolites correlates with the presence of HCV-RNA in saliva. Saliva of 39 HCV-positive patients and 13 HCV-negative patients, without clinical or laboratorial evidence of liver disease were tested for nitric oxide metabolites. HCV-RNA was detected in serum and saliva by a RT-PCR method and nitric oxide level was determined by evaluation of its stable degradation products, nitrate and nitrite. No differences were found between the concentration of nitrite in saliva from HCV patients and controls, in despite of the presence or not of HCV RNA in saliva. Patients with HCV and cirrhosis had higher concentrations of nitrite but not significantly different from the control group or the groups of anti-HCV patients without cirrhosis. Increased levels of nitrite were not detected in anti-HCV positive patients, an indirect indication that chronic sialoadenitis are infrequent in these patients or occurs with low intensity not sufficient to increase nitric oxide metabolite levels in saliva.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822005000600001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822005000600001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.38 n.6 2005
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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