Circulating microRNAs in insulin resistant horses and ponies
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/1177 |
Resumo: | Insulin resistance is a prevalent disorder among horses and is associated with abnormal adiposity, laminitis, equine metabolic syndrome, and pituitary pars intermedia dysfunction. The processes leading to equine insulin resistance and associated conditions remain subject for study. MicroRNAs (miRNAs) are involved in regulation of many biological processes and diseases. The current study aimed to investigate the circulating miRNA profile of insulin resistant horses and ponies. It was hypothesized that insulin resistant horses would have a different circulating miRNA profile compared to healthy ones. 12 Thoroughbred/ Thoroughbred-cross and 12 Welsh/Dartmoor non-pregnant mares were evaluated for insulin sensitivity using frequent sampling intravenous glucose tolerance test (FSIGTT). Serum samples were collected for miRNA profiling through RT-qPCR analysis. Horses and ponies were divided into insulin sensitive (IS) or insulin resistant (IR) groups and their miRNA profiles compared. Results demonstrated that 13 miRNAs were differently expressed between IR and IS horses, 15 between IR and IS ponies, 17 between horses and ponies, and 10 between IR and IS animals (horses and ponies combined) (p<0.05). Finally, 8 miRNAs were proposed as potential regulators of equine insulin resistance. miRNA profiling is a potential tool to evaluate insulin resistance and associated conditions. |
id |
SBMV-1_1013e406e8493d0e122f6a838bdc5a51 |
---|---|
oai_identifier_str |
oai:ojs.rbmv.org:article/1177 |
network_acronym_str |
SBMV-1 |
network_name_str |
Brazilian Journal of Veterinary Medicine |
repository_id_str |
|
spelling |
Circulating microRNAs in insulin resistant horses and poniesMicroRNAs circulantes em cavalos e pônies com resistência à insulinasíndrome metabólica equina, resistência à insulina, laminite, microRNA.equine metabolic syndrome, insulin resistance, laminitis, microRNA. Insulin resistance is a prevalent disorder among horses and is associated with abnormal adiposity, laminitis, equine metabolic syndrome, and pituitary pars intermedia dysfunction. The processes leading to equine insulin resistance and associated conditions remain subject for study. MicroRNAs (miRNAs) are involved in regulation of many biological processes and diseases. The current study aimed to investigate the circulating miRNA profile of insulin resistant horses and ponies. It was hypothesized that insulin resistant horses would have a different circulating miRNA profile compared to healthy ones. 12 Thoroughbred/ Thoroughbred-cross and 12 Welsh/Dartmoor non-pregnant mares were evaluated for insulin sensitivity using frequent sampling intravenous glucose tolerance test (FSIGTT). Serum samples were collected for miRNA profiling through RT-qPCR analysis. Horses and ponies were divided into insulin sensitive (IS) or insulin resistant (IR) groups and their miRNA profiles compared. Results demonstrated that 13 miRNAs were differently expressed between IR and IS horses, 15 between IR and IS ponies, 17 between horses and ponies, and 10 between IR and IS animals (horses and ponies combined) (p<0.05). Finally, 8 miRNAs were proposed as potential regulators of equine insulin resistance. miRNA profiling is a potential tool to evaluate insulin resistance and associated conditions.Resistência à insulina é um problema prevalente em cavalos associado à adiposidade excessiva, síndrome metabólica, laminite e adenoma da parte intermédia da pituitária. A fisiopatologia que leva à resistência à insulina e doenças associadas é assunto de grande interesse na pesquisa. Micro RNAs (miRNAs) são envolvidos na regulação de diversos processos biológicos e doenças. O presente estudo tem como objetivo avaliar o perfil de miRNAs circulante em cavalos e pôneis com resistência à insulina. Nossa hipótese principal é que cavalos com resistência à insulina tem um perfil circulatório diferente de animais normais. Doze cavalos da raça Puro Sangue Inglês (PSI) e cruza PSI e doze pôneis da raça Welsh e Dartmoor foram avaliados quanto a sua sensibilidade à insulina usando o teste de tolerância à glicose intravenosa de coletas frequentes. Amostras de soro foram coletadas para determinação do perfil de miRNA a partir da análise de RT-qPCR. Cavalos e pôneis foram divididos em grupos de animais sensíveis (IS) e resistentes à insulina (RI). Análise dos resultados demonstraram 13 miRNA tiveram expressão diferente entre cavalos IS e IR, 15 diferentes entre pôneis IS e IR, 17 miRNA diferentes entre pôneis e cavalos, e 10 miRNA diferentes entre animais IS e IR (pôneis e cavalos combinados) (p<0.05). Oito destes miRNA são reguladores de resistência à insulina. O perfil de miRNA pode ser usado como ferramenta para o maior entendimento dos mecanismos que levam a resistência à insulina e patologias associadasSociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdftext/xmlhttps://rbmv.org/BJVM/article/view/117710.29374/2527-2179.bjvm003620Brazilian Journal of Veterinary Medicine; Vol. 43 No. 1 (2021); e003620Revista Brasileira de Medicina Veterinária; v. 43 n. 1 (2021); e0036202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1177/1086https://rbmv.org/BJVM/article/view/1177/1223Copyright (c) 2021 Hugo Felipe da Costa Santos, Tanja Maria Hess, Jason Brummer, Peter Graham, Brigett Mcintosh, Rebecca Splanhttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Hugo Felipe da Costa Hess, Tanja Maria Brummer, Jason Graham, Peter Mcintosh, Brigett Splan, Rebecca 2022-06-27T13:02:53Zoai:ojs.rbmv.org:article/1177Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2022-06-27T13:02:53Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Circulating microRNAs in insulin resistant horses and ponies MicroRNAs circulantes em cavalos e pônies com resistência à insulina |
title |
Circulating microRNAs in insulin resistant horses and ponies |
spellingShingle |
Circulating microRNAs in insulin resistant horses and ponies Santos, Hugo Felipe da Costa síndrome metabólica equina, resistência à insulina, laminite, microRNA. equine metabolic syndrome, insulin resistance, laminitis, microRNA. |
title_short |
Circulating microRNAs in insulin resistant horses and ponies |
title_full |
Circulating microRNAs in insulin resistant horses and ponies |
title_fullStr |
Circulating microRNAs in insulin resistant horses and ponies |
title_full_unstemmed |
Circulating microRNAs in insulin resistant horses and ponies |
title_sort |
Circulating microRNAs in insulin resistant horses and ponies |
author |
Santos, Hugo Felipe da Costa |
author_facet |
Santos, Hugo Felipe da Costa Hess, Tanja Maria Brummer, Jason Graham, Peter Mcintosh, Brigett Splan, Rebecca |
author_role |
author |
author2 |
Hess, Tanja Maria Brummer, Jason Graham, Peter Mcintosh, Brigett Splan, Rebecca |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Hugo Felipe da Costa Hess, Tanja Maria Brummer, Jason Graham, Peter Mcintosh, Brigett Splan, Rebecca |
dc.subject.por.fl_str_mv |
síndrome metabólica equina, resistência à insulina, laminite, microRNA. equine metabolic syndrome, insulin resistance, laminitis, microRNA. |
topic |
síndrome metabólica equina, resistência à insulina, laminite, microRNA. equine metabolic syndrome, insulin resistance, laminitis, microRNA. |
description |
Insulin resistance is a prevalent disorder among horses and is associated with abnormal adiposity, laminitis, equine metabolic syndrome, and pituitary pars intermedia dysfunction. The processes leading to equine insulin resistance and associated conditions remain subject for study. MicroRNAs (miRNAs) are involved in regulation of many biological processes and diseases. The current study aimed to investigate the circulating miRNA profile of insulin resistant horses and ponies. It was hypothesized that insulin resistant horses would have a different circulating miRNA profile compared to healthy ones. 12 Thoroughbred/ Thoroughbred-cross and 12 Welsh/Dartmoor non-pregnant mares were evaluated for insulin sensitivity using frequent sampling intravenous glucose tolerance test (FSIGTT). Serum samples were collected for miRNA profiling through RT-qPCR analysis. Horses and ponies were divided into insulin sensitive (IS) or insulin resistant (IR) groups and their miRNA profiles compared. Results demonstrated that 13 miRNAs were differently expressed between IR and IS horses, 15 between IR and IS ponies, 17 between horses and ponies, and 10 between IR and IS animals (horses and ponies combined) (p<0.05). Finally, 8 miRNAs were proposed as potential regulators of equine insulin resistance. miRNA profiling is a potential tool to evaluate insulin resistance and associated conditions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/1177 10.29374/2527-2179.bjvm003620 |
url |
https://rbmv.org/BJVM/article/view/1177 |
identifier_str_mv |
10.29374/2527-2179.bjvm003620 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/1177/1086 https://rbmv.org/BJVM/article/view/1177/1223 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/xml |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 43 No. 1 (2021); e003620 Revista Brasileira de Medicina Veterinária; v. 43 n. 1 (2021); e003620 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313110783655936 |