Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/1072 |
Resumo: | Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. |
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Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery systemImobilização química de capivaras de vida livre (Hydrochoerus hydrochaeris) usando a combinação cetamina-dexmedetomidina e um sistema de administração remota de medicamentosRDDS, contenção química, sinantrópicas, atipamezol, capivara.RDDS, wildlife chemical restraint, atipamezole, capybara.Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions.Capturar capivaras selvagens para projetos científicos, controle populacional ou intervenções médicas é uma necessidade crescente. Com este estudo, pretendemos avaliar uma associação de cetamina / dexmedetomidina como uma contenção química reversível em capivaras sinantrópicas de vida livre, buscando melhorar as características anestésicas e de recuperação e, ao mesmo tempo, testar um sistema remoto de liberação controlada de medicamentos (RDDS). Para tanto, 18 capivaras adultas (machos n = 8; fêmeas n = 10) (67,3 ± 9,45 kg), antes da contenção química, foram fisicamente confinadas, e receberam dardos por via intramuscular com 9 mg kg-1 de cetamina e 0,005 mg kg-1. dexmedetomidina. Após a intervenção, 0,005 mg kg-1 de atipamezol foi administrado via IM, e utilizado como agente de reversão (RA), (n = 5). Os efeitos anestésicos foram registrados como período de latência (LP I / primeiros efeitos observados) (LP II / decúbito lateral mais tempo para manipular o animal). O tempo de recuperação foi dividido em (R1 / sem AR, totalmente recuperado / pronto para liberação da contenção física), (R2a / R2b, com AR, tempo para deambular mais tempo para recuperação total / liberação, respectivamente). Os sinais vitais foram registrados em um intervalo de 15 minutos. O GraphPad Prism 8.1.1 foi utilizado para realizar o teste t não pareado, com um valor p ˂ 0,05 considerado significativo. Resultados: LP médio I: 3 ± 1 min; LP II: 10 ± 2 min. Duração do procedimento: 49 ± 5 min. Tempo de recuperação sem AR, (R1): 55 ± 15 min., Em comparação aos 18min, com AR (R2a) até em posição para caminhar (com descoordenação grave), necessitou de tempo adicional até a recuperação completa (pronto para liberação): ± 45 min (R2b) . Tempo total, para liberação (R2a / b): média ± DP = 67 ± 13,85 min. Concluiu-se, por relevância clínica, que a associação de cetamina e dexmedetomidina teve um desempenho satisfatório, proporcionando sedação e analgesia eficazes e períodos relativamente curtos de latência. A RA utilizada não reduziu significativamente o tempo total de recuperação (valor P = 0,7328). Os efeitos adversos, como o risco de timpanismo no ceco agudo, devido à falta de jejum pré-anestésico, concomitante aos efeitos colaterais dos anestésicos injetáveis e voláteis sobre a motilidade do trato digestivo, e bradicardia / hipertermia induzida, exigem cautela extra. O RDDS utilizado forneceu entrega confiável de medicamentos em condições de campo.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/107210.29374/2527-2179.bjvm107220Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e107220Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e1072202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1072/984Copyright (c) 2020 DEREK ROSENFIELD, Mario Ferraro, Claudia Igayara, Silvia Renata Gaigo Cortopassi, Cristiane Schilbach Pizzuttohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessROSENFIELD, DEREKFerraro, MarioIgayara, ClaudiaGaigo Cortopassi, Silvia RenataSchilbach Pizzutto, Cristiane2021-05-13T13:46:40Zoai:ojs.rbmv.org:article/1072Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-05-13T13:46:40Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system Imobilização química de capivaras de vida livre (Hydrochoerus hydrochaeris) usando a combinação cetamina-dexmedetomidina e um sistema de administração remota de medicamentos |
title |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system |
spellingShingle |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system ROSENFIELD, DEREK RDDS, contenção química, sinantrópicas, atipamezol, capivara. RDDS, wildlife chemical restraint, atipamezole, capybara. |
title_short |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system |
title_full |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system |
title_fullStr |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system |
title_full_unstemmed |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system |
title_sort |
Chemical immobilization of free-living capybaras (Hydrochoerus hydrochaeris) using ketamine-dexmedetomidine combination and a remote drug delivery system |
author |
ROSENFIELD, DEREK |
author_facet |
ROSENFIELD, DEREK Ferraro, Mario Igayara, Claudia Gaigo Cortopassi, Silvia Renata Schilbach Pizzutto, Cristiane |
author_role |
author |
author2 |
Ferraro, Mario Igayara, Claudia Gaigo Cortopassi, Silvia Renata Schilbach Pizzutto, Cristiane |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
ROSENFIELD, DEREK Ferraro, Mario Igayara, Claudia Gaigo Cortopassi, Silvia Renata Schilbach Pizzutto, Cristiane |
dc.subject.por.fl_str_mv |
RDDS, contenção química, sinantrópicas, atipamezol, capivara. RDDS, wildlife chemical restraint, atipamezole, capybara. |
topic |
RDDS, contenção química, sinantrópicas, atipamezol, capivara. RDDS, wildlife chemical restraint, atipamezole, capybara. |
description |
Capturing wild capybaras for scientific projects, population control or medical interventions is a growing necessity. With this study, we intended to evaluate a Ketamine/Dexmedetomidine as a reversible chemical restraint in free-ranging synanthropic capybaras, seeking enhanced anesthetic and recovery characteristics while testing a specialized remote drug delivery system (RDDS). For this purpose, 18 adult capybaras (male n = 8; females n = 10) (67.3 ± 9.45 kg), prior to chemical restraint, were physically confined, subsequently darted intramuscularly with 9 mg kg-1 ketamine and 0,005 mg kg-1 dexmedetomidine. Post-intervention, 0,005 mg kg-1 atipamezole, administered IM, was used as a reversal agent (RA), (n = 5). Anesthetic effects were recorded as latency period (LP I/first observed effects) (LP II /lateral recumbency plus time to handle the animal). Recovery time was divided into (R1/no RA, fully recovered/ready for release), (R2a/R2b, with RA, time to ambulant position plus time to full recovery/release, respectively). Vital signs were recorded at a 15-minute interval. GraphPad Prism 8.1.1 was used to perform unpaired t-test, with a p-value ˂ 0,05 considered significant. Results: Mean LP I: 3 ± 1 min.; LP II: 10 ± 2 min. Procedure duration: 49 ± 5 min. Recovery time without RA, (R1): 55 ± 15 min., compared to 18 min., with RA (R2a) to ambulant position (with severe discoordination), requiring additional time until full recovery (ready for release): ± 45 min (R2b). Total time, to release (R2a/b): mean ± SD = 67 ± 13.85 min. Concluding for clinical relevance that the association of Ketamine and Dexmedetomidine performed satisfactorily, providing effective sedation and analgesia, and relative short latency periods. Used RA did not shorten total recovery time significantly (P-value = 0,7328). Adverse effects such as the risk of acute cecal tympany, due to the lack of pre-anesthetic fasting, concurrent to collateral effects of injectable and volatile anesthetics on the motility of the digestive tract, and induced bradycardia/hyperthermia warrant extra caution. The employed RDDS provided reliable drug delivery under field conditions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/1072 10.29374/2527-2179.bjvm107220 |
url |
https://rbmv.org/BJVM/article/view/1072 |
identifier_str_mv |
10.29374/2527-2179.bjvm107220 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/1072/984 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e107220 Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e107220 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313110638952448 |