Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/890 |
Resumo: | Doxorubicin (DOX) is a chemotherapeutic agent from anthracycline family used in the treatment of different neoplasms, however, it has a cardiotoxic side effect. The mean goal was to evaluate the pequi shell ethanolic extract (PSEE) effect on the activity of antioxidant enzyme glutathione reductase (GSH-Rd) in rats with doxorubicin-induced cardiotoxicity. Wistar rats were distributed in six groups of five animals each, with 1 ml of physiological solution applied in rats of sham group (GS); 16 mg/kg of DOX in animals of control group (GC); 16 mg/kg of DOX and 300 mg/kg of PSEE for 17 days in rats of G1; 16 mg/kg of DOX and 600 mg/kg of PSEE for 17 days in animals of G2; 16 mg/kg of DOX and 300 mg/kg of PSEE from the seventh day, for 10 days in rats of G3; and 16 mg/kg of DOX and 600 mg/kg of PSEE from the seventh day, for 10 days in animals of G4. The DOX and the physiological solution were applied on the 14th day after experiment start. It was quantified by spectrophotometry. At the dose of 300 mg/kg for 17 days the PSEE has increased the enzymatic capacity of GSH-Rd. It was concluded that PSEE at the dose of 300 mg/kg for 17 days increase the activity of the GSH-Rd enzyme, which may reflect positively along the deleterious effects of DOX in the myocardium of rats. |
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Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicityEFEITO DO EXTRATO ETANÓLICO DA CASCA DO PEQUI SOBRE A ENZIMA GLUTATIONA REDUTASE EM RATOS SUBMETIDOS A CARDIOTOXICIDADE POR DOXORRUBICINAEstresse oxidativo, antioxidante, enzima, ratos.Oxidative stress, antioxidant, enzyme, rats.Doxorubicin (DOX) is a chemotherapeutic agent from anthracycline family used in the treatment of different neoplasms, however, it has a cardiotoxic side effect. The mean goal was to evaluate the pequi shell ethanolic extract (PSEE) effect on the activity of antioxidant enzyme glutathione reductase (GSH-Rd) in rats with doxorubicin-induced cardiotoxicity. Wistar rats were distributed in six groups of five animals each, with 1 ml of physiological solution applied in rats of sham group (GS); 16 mg/kg of DOX in animals of control group (GC); 16 mg/kg of DOX and 300 mg/kg of PSEE for 17 days in rats of G1; 16 mg/kg of DOX and 600 mg/kg of PSEE for 17 days in animals of G2; 16 mg/kg of DOX and 300 mg/kg of PSEE from the seventh day, for 10 days in rats of G3; and 16 mg/kg of DOX and 600 mg/kg of PSEE from the seventh day, for 10 days in animals of G4. The DOX and the physiological solution were applied on the 14th day after experiment start. It was quantified by spectrophotometry. At the dose of 300 mg/kg for 17 days the PSEE has increased the enzymatic capacity of GSH-Rd. It was concluded that PSEE at the dose of 300 mg/kg for 17 days increase the activity of the GSH-Rd enzyme, which may reflect positively along the deleterious effects of DOX in the myocardium of rats.A doxorrubicina é quimioterápico amplamente utilizado no tratamento de neoplasias que possui como efeito colateral ser cardiotóxico. O objetivo foi avaliar a ação do extrato etanólico da casca do pequi (EECP) sobre a atividade da enzima antioxidante glutationa redutase (GSH-Rd) no miocárdio de ratos submetidos a cardiotoxicidade por doxorrubicina (DOX). Foram utilizados 30 ratos da raça Wistar, distribuídos em seis grupos de cinco animais. Nos ratos do grupo sham (GS) foi aplicado 1 ml de solução fisiológica; do controle (GC) 16 mg/kg de DOX; do G1 16 mg/kg de DOX e 300 mg/kg de EECP durante 17 dias; do G2 16 mg/kg de DOX e 600 mg/kg de EECP durante 17 dias; do G3 16 mg/kg de DOX e 300 mg/kg de EECP durante 10 dias; e do G4 16 mg/kg de DOX e 600 mg/kg de EECP durante 10 dias. A quantificação enzimática foi mensurada por leitura da absorbância em espectrofotômetro. Na dose de 300 mg/kg durante 17 dias o EECP aumentou significativamente a atividade enzimática da GSH-Rd. Concluiu-se que o EECP na dose de 300 mg/kg durante 17 dias aumenta a atividade da enzima GSH-Rd, o que pode refletir positivamente junto aos efeitos deletérios da DOX no miocárdio de ratos.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2018-08-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/89010.29374/2527-2179.bjvm89019Brazilian Journal of Veterinary Medicine; Vol. 40 No. 1 (2018); e89018Revista Brasileira de Medicina Veterinária; v. 40 n. 1 (2018); e890182527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/890/787Copyright (c) 2018 Léa Resende Moura, Loanny Maria de Almeida, Raquel Emanuelle de Jesus Neves, Ângela Alves Viegas, Claudinei Sousa Lima, Veridiana M. B. D. Mourainfo:eu-repo/semantics/openAccessMoura, Léa Resendede Almeida, Loanny MariaNeves, Raquel Emanuelle de JesusViegas, Ângela AlvesLima, Claudinei SousaMoura, Veridiana M. B. D.2021-03-12T18:04:48Zoai:ojs.rbmv.org:article/890Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-03-12T18:04:48Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity EFEITO DO EXTRATO ETANÓLICO DA CASCA DO PEQUI SOBRE A ENZIMA GLUTATIONA REDUTASE EM RATOS SUBMETIDOS A CARDIOTOXICIDADE POR DOXORRUBICINA |
title |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity |
spellingShingle |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity Moura, Léa Resende Estresse oxidativo, antioxidante, enzima, ratos. Oxidative stress, antioxidant, enzyme, rats. |
title_short |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity |
title_full |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity |
title_fullStr |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity |
title_full_unstemmed |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity |
title_sort |
Effect Effect of pequi shell ethanolic extract on glutathione reductase activity in rats with doxorubicin-induced cardiotoxicity |
author |
Moura, Léa Resende |
author_facet |
Moura, Léa Resende de Almeida, Loanny Maria Neves, Raquel Emanuelle de Jesus Viegas, Ângela Alves Lima, Claudinei Sousa Moura, Veridiana M. B. D. |
author_role |
author |
author2 |
de Almeida, Loanny Maria Neves, Raquel Emanuelle de Jesus Viegas, Ângela Alves Lima, Claudinei Sousa Moura, Veridiana M. B. D. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Moura, Léa Resende de Almeida, Loanny Maria Neves, Raquel Emanuelle de Jesus Viegas, Ângela Alves Lima, Claudinei Sousa Moura, Veridiana M. B. D. |
dc.subject.por.fl_str_mv |
Estresse oxidativo, antioxidante, enzima, ratos. Oxidative stress, antioxidant, enzyme, rats. |
topic |
Estresse oxidativo, antioxidante, enzima, ratos. Oxidative stress, antioxidant, enzyme, rats. |
description |
Doxorubicin (DOX) is a chemotherapeutic agent from anthracycline family used in the treatment of different neoplasms, however, it has a cardiotoxic side effect. The mean goal was to evaluate the pequi shell ethanolic extract (PSEE) effect on the activity of antioxidant enzyme glutathione reductase (GSH-Rd) in rats with doxorubicin-induced cardiotoxicity. Wistar rats were distributed in six groups of five animals each, with 1 ml of physiological solution applied in rats of sham group (GS); 16 mg/kg of DOX in animals of control group (GC); 16 mg/kg of DOX and 300 mg/kg of PSEE for 17 days in rats of G1; 16 mg/kg of DOX and 600 mg/kg of PSEE for 17 days in animals of G2; 16 mg/kg of DOX and 300 mg/kg of PSEE from the seventh day, for 10 days in rats of G3; and 16 mg/kg of DOX and 600 mg/kg of PSEE from the seventh day, for 10 days in animals of G4. The DOX and the physiological solution were applied on the 14th day after experiment start. It was quantified by spectrophotometry. At the dose of 300 mg/kg for 17 days the PSEE has increased the enzymatic capacity of GSH-Rd. It was concluded that PSEE at the dose of 300 mg/kg for 17 days increase the activity of the GSH-Rd enzyme, which may reflect positively along the deleterious effects of DOX in the myocardium of rats. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/890 10.29374/2527-2179.bjvm89019 |
url |
https://rbmv.org/BJVM/article/view/890 |
identifier_str_mv |
10.29374/2527-2179.bjvm89019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/890/787 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 40 No. 1 (2018); e89018 Revista Brasileira de Medicina Veterinária; v. 40 n. 1 (2018); e89018 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313110109421568 |