Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs

Detalhes bibliográficos
Autor(a) principal: de Almeida, Julio Cesar Neves
Data de Publicação: 2023
Outros Autores: de Carvalho, Heloísa Cristina Teixeira, Gila, Lana Isabella, Martins, Nathana Beatriz, Szabó, Matias Pablo Juan, da Hora, Aline Santana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Medicine
Texto Completo: https://bjvm.org.br/BJVM/article/view/1294
Resumo: This case involved a 2-year-old neutered male domestic mixed-breed cat that was rescued from the street eight months earlier. The animal presented with weakness, hyporexia, progressive weight loss, fatigue, uveitis, pale mucous membranes, dehydration (7%), and pelvic limb paresis. Aqueous humor was collected for molecular analysis for the differential diagnosis of potential etiological agents [Feline coronavirus (FCoV), Feline leukemia virus (FeLV), Feline immunodeficiency virus (FIV), Toxoplasma gondii, Cryptococcus spp., Felid herpesvirus-1 (FHV-1) and Bartonella spp.] of feline uveitis. The sample was positive by real-time reverse transcription-polymerase chain reaction (RT-qPCR) for FCoV and RT-qPCR and real-time polymerase chain reaction (qPCR) for FeLV and qPCR FIV. The cat was euthanized due to poor clinical outcomes and prognosis. A cerebrospinal fluid (CSF) sample was collected and tested, and the same pathogens were found in the aqueous humor. Small-cell follicular multicenter lymphoma and multifocal pyogranulomatous meningoencephalitis were observed upon histopathological analysis. In this study, aqueous humor and cerebrospinal fluid samples were efficient for the detection of coinfection with FIV, FeLV, and FCoV.
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spelling Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signsUso de amostras selecionadas para uma doença viral felina de difícil diagnóstico em gato com uveíte e sinal neurológicomolecular diagnosis, feline immunodeficiency virus, feline leukemia virus, feline infectious peritonitis virus.diagnóstico molecular, vírus da imunodeficiência felina, vírus da leucemia felina, vírus da peritonite infecciosa felinaThis case involved a 2-year-old neutered male domestic mixed-breed cat that was rescued from the street eight months earlier. The animal presented with weakness, hyporexia, progressive weight loss, fatigue, uveitis, pale mucous membranes, dehydration (7%), and pelvic limb paresis. Aqueous humor was collected for molecular analysis for the differential diagnosis of potential etiological agents [Feline coronavirus (FCoV), Feline leukemia virus (FeLV), Feline immunodeficiency virus (FIV), Toxoplasma gondii, Cryptococcus spp., Felid herpesvirus-1 (FHV-1) and Bartonella spp.] of feline uveitis. The sample was positive by real-time reverse transcription-polymerase chain reaction (RT-qPCR) for FCoV and RT-qPCR and real-time polymerase chain reaction (qPCR) for FeLV and qPCR FIV. The cat was euthanized due to poor clinical outcomes and prognosis. A cerebrospinal fluid (CSF) sample was collected and tested, and the same pathogens were found in the aqueous humor. Small-cell follicular multicenter lymphoma and multifocal pyogranulomatous meningoencephalitis were observed upon histopathological analysis. In this study, aqueous humor and cerebrospinal fluid samples were efficient for the detection of coinfection with FIV, FeLV, and FCoV.O caso refere-se a um gato de dois anos de idade, sem raça definida, resgatado da rua há oito meses. O animal apresentava fraqueza, hiporexia, emagrecimento progressivo, cansaço fácil, uveíte, mucosas pálidas, desidratação (7%) e paresia de membros pélvicos. O humor aquoso foi coletado para o diagnóstico molecular diferencial de potenciais agentes etiológicos [coronavírus felino (FCoV), vírus da leucemia felina (FeLV), vírus da imunodeficiência felina (FIV), Toxoplasma gondii, Cryptococcus spp., herpesvírus felino tipo 1 (FHV-1) and Bartonella spp.] causadores de uveíte felina. A amostra foi positiva na reação em cadeia da polimerase precedida por transcrição reversa em tempo real (RT-qPCR) para FCoV, RT-qPCR e reação em cadeia da polimerase em tempo real (qPCR) para FeLV e qPCR para FIV. O animal foi submetido à eutanásia - devido ao quadro clínico e prognóstico desfavorável. Amostra de líquido cefalorraquidiano (LCR) foi coletada e testada, confirmando a identificação dos mesmos patógenos encontrados no humor aquoso. Linfoma multicêntrico folicular de pequenas células e meningoencefalite piogranulomatosa multifocal foram observados na análise histopatológica. Neste relato, as amostras de humor aquoso e líquido cefalorraquidiano foram eficientes para a detecção de coinfecção por FIV, FeLV e FCoV.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2023-07-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://bjvm.org.br/BJVM/article/view/129410.29374/2527-2179.bjvm001223Brazilian Journal of Veterinary Medicine; Vol. 45 (2023); e001223Revista Brasileira de Medicina Veterinária; v. 45 (2023); e0012232527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://bjvm.org.br/BJVM/article/view/1294/1327https://bjvm.org.br/BJVM/article/view/1294/1336Copyright (c) 2023 Julio Cesar Neves de Almeida, Heloísa Cristina Teixeira de Carvalho, Lana Isabella Gila, Nathana Beatriz Martins, Matias Pablo Juan Szabó, Aline Santana da Horahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessde Almeida, Julio Cesar Nevesde Carvalho, Heloísa Cristina TeixeiraGila, Lana IsabellaMartins, Nathana BeatrizSzabó, Matias Pablo Juanda Hora, Aline Santana2023-08-04T20:25:06Zoai:ojs.rbmv.org:article/1294Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2023-08-04T20:25:06Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false
dc.title.none.fl_str_mv Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
Uso de amostras selecionadas para uma doença viral felina de difícil diagnóstico em gato com uveíte e sinal neurológico
title Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
spellingShingle Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
de Almeida, Julio Cesar Neves
molecular diagnosis, feline immunodeficiency virus, feline leukemia virus, feline infectious peritonitis virus.
diagnóstico molecular, vírus da imunodeficiência felina, vírus da leucemia felina, vírus da peritonite infecciosa felina
title_short Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
title_full Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
title_fullStr Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
title_full_unstemmed Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
title_sort Use of selected samples to diagnose a tricky feline viral disease in a cat with uveitis and neurological signs
author de Almeida, Julio Cesar Neves
author_facet de Almeida, Julio Cesar Neves
de Carvalho, Heloísa Cristina Teixeira
Gila, Lana Isabella
Martins, Nathana Beatriz
Szabó, Matias Pablo Juan
da Hora, Aline Santana
author_role author
author2 de Carvalho, Heloísa Cristina Teixeira
Gila, Lana Isabella
Martins, Nathana Beatriz
Szabó, Matias Pablo Juan
da Hora, Aline Santana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv de Almeida, Julio Cesar Neves
de Carvalho, Heloísa Cristina Teixeira
Gila, Lana Isabella
Martins, Nathana Beatriz
Szabó, Matias Pablo Juan
da Hora, Aline Santana
dc.subject.por.fl_str_mv molecular diagnosis, feline immunodeficiency virus, feline leukemia virus, feline infectious peritonitis virus.
diagnóstico molecular, vírus da imunodeficiência felina, vírus da leucemia felina, vírus da peritonite infecciosa felina
topic molecular diagnosis, feline immunodeficiency virus, feline leukemia virus, feline infectious peritonitis virus.
diagnóstico molecular, vírus da imunodeficiência felina, vírus da leucemia felina, vírus da peritonite infecciosa felina
description This case involved a 2-year-old neutered male domestic mixed-breed cat that was rescued from the street eight months earlier. The animal presented with weakness, hyporexia, progressive weight loss, fatigue, uveitis, pale mucous membranes, dehydration (7%), and pelvic limb paresis. Aqueous humor was collected for molecular analysis for the differential diagnosis of potential etiological agents [Feline coronavirus (FCoV), Feline leukemia virus (FeLV), Feline immunodeficiency virus (FIV), Toxoplasma gondii, Cryptococcus spp., Felid herpesvirus-1 (FHV-1) and Bartonella spp.] of feline uveitis. The sample was positive by real-time reverse transcription-polymerase chain reaction (RT-qPCR) for FCoV and RT-qPCR and real-time polymerase chain reaction (qPCR) for FeLV and qPCR FIV. The cat was euthanized due to poor clinical outcomes and prognosis. A cerebrospinal fluid (CSF) sample was collected and tested, and the same pathogens were found in the aqueous humor. Small-cell follicular multicenter lymphoma and multifocal pyogranulomatous meningoencephalitis were observed upon histopathological analysis. In this study, aqueous humor and cerebrospinal fluid samples were efficient for the detection of coinfection with FIV, FeLV, and FCoV.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://bjvm.org.br/BJVM/article/view/1294
10.29374/2527-2179.bjvm001223
url https://bjvm.org.br/BJVM/article/view/1294
identifier_str_mv 10.29374/2527-2179.bjvm001223
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://bjvm.org.br/BJVM/article/view/1294/1327
https://bjvm.org.br/BJVM/article/view/1294/1336
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/xml
dc.publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Medicine; Vol. 45 (2023); e001223
Revista Brasileira de Medicina Veterinária; v. 45 (2023); e001223
2527-2179
0100-2430
reponame:Brazilian Journal of Veterinary Medicine
instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron:SBMV
instname_str Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron_str SBMV
institution SBMV
reponame_str Brazilian Journal of Veterinary Medicine
collection Brazilian Journal of Veterinary Medicine
repository.name.fl_str_mv Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
repository.mail.fl_str_mv contato.rbmv@gmail.com
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