Comment on stem cells of cancer: A new therapeutic target?
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/213 |
Resumo: | ABSTRACT. Vasconcellos M. [Comment on stem cells of cancer: A new therapeutic target?] Comentário sobre células-tronco do câncer: Um novo alvo terapêutico? Revista Brasileira de Medicina Veterinária 38(2):111-115, 2016. Programa de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, Cidade Universitária, Fundão, RJ 21940-902, Brasil. E-mail: marcelvasconcellos@yahoo.com.br The cancer affects about 500,000 new cases each year in Brazil. The understanding of carcinogenesis is still one of the most current and controversial issues in the field of research. The theory of cellular hierarchy revive an old hypothesis of a tumor subpopulation called cancer stem cells (CSC’s) with unique characteristics of self-renewal and tumorigenicity, which grew in evidence from their identification and isolation in many human tumors. To discuss the impact that the validation of the theory of CSC’s can cause in relation to the current treatment of the disease. Critical analysis of scientific publications obtained through the electronic databases Medline, Lilacs, and Scielo researching the keywords: stem cells, cancer stem cells, clonal evolution. Articles were selected from the 90 by the year 2014. Studies using CSC’s anti-drugs targeting selective inhibition of cell self-renewal pathways specifically by surface markers for vehicle cytotoxic agents, had success in tests preliminary. Prospects for a reorientation of therapeutic targets through selective elimination of CSC’s preserving however, normal stem cells, represents the current goal to be achieved by researchers and biopharmaceutical companies worldwide. |
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Comment on stem cells of cancer: A new therapeutic target?Comentário sobre células-tronco do câncer: Um novo alvo terapêutico?Evolução clonalcarcinogênesecélulas-troncoClonal evolutioncarcinogenesisstem cellsABSTRACT. Vasconcellos M. [Comment on stem cells of cancer: A new therapeutic target?] Comentário sobre células-tronco do câncer: Um novo alvo terapêutico? Revista Brasileira de Medicina Veterinária 38(2):111-115, 2016. Programa de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, Cidade Universitária, Fundão, RJ 21940-902, Brasil. E-mail: marcelvasconcellos@yahoo.com.br The cancer affects about 500,000 new cases each year in Brazil. The understanding of carcinogenesis is still one of the most current and controversial issues in the field of research. The theory of cellular hierarchy revive an old hypothesis of a tumor subpopulation called cancer stem cells (CSC’s) with unique characteristics of self-renewal and tumorigenicity, which grew in evidence from their identification and isolation in many human tumors. To discuss the impact that the validation of the theory of CSC’s can cause in relation to the current treatment of the disease. Critical analysis of scientific publications obtained through the electronic databases Medline, Lilacs, and Scielo researching the keywords: stem cells, cancer stem cells, clonal evolution. Articles were selected from the 90 by the year 2014. Studies using CSC’s anti-drugs targeting selective inhibition of cell self-renewal pathways specifically by surface markers for vehicle cytotoxic agents, had success in tests preliminary. Prospects for a reorientation of therapeutic targets through selective elimination of CSC’s preserving however, normal stem cells, represents the current goal to be achieved by researchers and biopharmaceutical companies worldwide.O câncer atinge cerca de 500.000 novos casos a cada ano no Brasil. A compreensão da carcinogênese é ainda uma das questões mais atuais e controversas no campo da pesquisa. A teoria da hierarquia celular revive uma antiga hipótese de uma subpopulação tumoral denominada células- -tronco tumorais (CTT’s) com características exclusivas de auto-renovação e tumorigenicidade, as quais cresceram em evidência a partir de sua identificação e isolamento em diversos tumores humanos. Discute-se o impacto que a validação da teoria das CTT’s pode causar em relação ao tratamento atual da doença. Realizou-se análise crítica de publicações científicas obtidas por meio das bases eletrônicas de dados Medline, Lilacs, e Scielo pesquisando-se as palavras-chave: stem cells, cancer stem cells, clonal evolution. Foram selecionados artigos a partir da década de 90 até o ano de 2014. Estudos utilizando drogas anti-CTT’s visando a inibição seletiva das vias de auto-renovação celular especificamente através de marcadores de superfície para veículos de agentes citotóxicos, apresentaram êxito em testes preliminares. As perspectivas de uma reorientação de alvos terapêuticos através da eliminação seletiva de CTT’s preservando, no entanto, células estaminais normais, representam a atual meta a ser alcançada por pesquisadores e empresas biofarmacêuticas em todo o mundo.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2016-06-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/213Brazilian Journal of Veterinary Medicine; Vol. 38 No. 2 (2016); 111-115Revista Brasileira de Medicina Veterinária; v. 38 n. 2 (2016); 111-1152527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVporhttps://rbmv.org/BJVM/article/view/213/138Vasconcellos, Marcelinfo:eu-repo/semantics/openAccess2020-12-23T17:26:02Zoai:ojs.rbmv.org:article/213Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:26:02Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Comment on stem cells of cancer: A new therapeutic target? Comentário sobre células-tronco do câncer: Um novo alvo terapêutico? |
title |
Comment on stem cells of cancer: A new therapeutic target? |
spellingShingle |
Comment on stem cells of cancer: A new therapeutic target? Vasconcellos, Marcel Evolução clonal carcinogênese células-tronco Clonal evolution carcinogenesis stem cells |
title_short |
Comment on stem cells of cancer: A new therapeutic target? |
title_full |
Comment on stem cells of cancer: A new therapeutic target? |
title_fullStr |
Comment on stem cells of cancer: A new therapeutic target? |
title_full_unstemmed |
Comment on stem cells of cancer: A new therapeutic target? |
title_sort |
Comment on stem cells of cancer: A new therapeutic target? |
author |
Vasconcellos, Marcel |
author_facet |
Vasconcellos, Marcel |
author_role |
author |
dc.contributor.author.fl_str_mv |
Vasconcellos, Marcel |
dc.subject.por.fl_str_mv |
Evolução clonal carcinogênese células-tronco Clonal evolution carcinogenesis stem cells |
topic |
Evolução clonal carcinogênese células-tronco Clonal evolution carcinogenesis stem cells |
description |
ABSTRACT. Vasconcellos M. [Comment on stem cells of cancer: A new therapeutic target?] Comentário sobre células-tronco do câncer: Um novo alvo terapêutico? Revista Brasileira de Medicina Veterinária 38(2):111-115, 2016. Programa de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, Cidade Universitária, Fundão, RJ 21940-902, Brasil. E-mail: marcelvasconcellos@yahoo.com.br The cancer affects about 500,000 new cases each year in Brazil. The understanding of carcinogenesis is still one of the most current and controversial issues in the field of research. The theory of cellular hierarchy revive an old hypothesis of a tumor subpopulation called cancer stem cells (CSC’s) with unique characteristics of self-renewal and tumorigenicity, which grew in evidence from their identification and isolation in many human tumors. To discuss the impact that the validation of the theory of CSC’s can cause in relation to the current treatment of the disease. Critical analysis of scientific publications obtained through the electronic databases Medline, Lilacs, and Scielo researching the keywords: stem cells, cancer stem cells, clonal evolution. Articles were selected from the 90 by the year 2014. Studies using CSC’s anti-drugs targeting selective inhibition of cell self-renewal pathways specifically by surface markers for vehicle cytotoxic agents, had success in tests preliminary. Prospects for a reorientation of therapeutic targets through selective elimination of CSC’s preserving however, normal stem cells, represents the current goal to be achieved by researchers and biopharmaceutical companies worldwide. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/213 |
url |
https://rbmv.org/BJVM/article/view/213 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/213/138 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 38 No. 2 (2016); 111-115 Revista Brasileira de Medicina Veterinária; v. 38 n. 2 (2016); 111-115 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
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1798313106954256384 |