Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/224 |
Resumo: | ABSTRACT. Calazans S.G., Fonseca-Alves C.E., Rodrigues P.C. & Magalhães G.M. [Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report.] Mastocitoma cutâneo canino, com progressão de baixo grau para alto grau - Relato de caso. Revista Brasileira de Medicina Veterinária, 38(2):147-152, 2016. Curso de Medicina Veterinária, Universidade de Franca, Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP 14404-600, Brasil. E-mail: sabryna.calazans@gmail.com Mast cell tumor is a common canine cutaneous neoplasm with variable biological behavior. Many studies in the literature evaluate predictive and prognostic factors for this neoplasm. The tumoral progression is an important phenomenon for many neoplasms, and in the canine prostatic neoplasm and squamous cell carcinoma this progression is well defined, however, don’t have a classic describe in the cutaneous canine mast cell tumors. This study reports the diagnostic and treatment assessment of cutaneous mast cell tumor in a dog presenting tumor progression. A five years old Shar Pei dog, male, 20 kg, was admitted to the veterinary clinic presenting chronic alopecia and pruritus and cutaneous nodules in left pelvic limb. The tumor was surgically excised and histopathological and immunohistochemistry examination diagnosed a low grade of mast cell tumor, membrane localization of c-KIT (KIT I) and ki-67 under 23 cells, in five high magnification fields. The tumor recurred five months after initial diagnostic presenting a nodule in the surgical region. After cytological examination, mast cell tumor was confirmed and, cytoreductive chemotherapy was started. The patient presented no response to treatment and new nodules arrised, so surgical resection was performed. Histopathological and immunohistochemistry examination was performed again demonstrating tumor progression as high grade mast cell tumor, citoplasmatic localization in c-KIT (KIT III) and ki-67 superior 23 cells. After surgical procedure, tyrosine kinase inhibitors therapy was started, but twenty days after the patient presented adverse effects and died. The mast cell tumors are common in Shar Pei dogs, by which histopathological and immunohistochemistry examinations should be considered as prognostic factors. Recurrent or metastatic mast cell tumors can show more aggressive patterns regarding primary tumors, wherefore clinical monitoring is very important during disease in these patients. |
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Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case reportMastocitoma cutâneo canino, com progressão de baixo grau para alto grau -Relato de casoCaninoc-kitki-6neoplasias cutâneasprogressão tumoralCaninec-kitki-67mast cell tumorABSTRACT. Calazans S.G., Fonseca-Alves C.E., Rodrigues P.C. & Magalhães G.M. [Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report.] Mastocitoma cutâneo canino, com progressão de baixo grau para alto grau - Relato de caso. Revista Brasileira de Medicina Veterinária, 38(2):147-152, 2016. Curso de Medicina Veterinária, Universidade de Franca, Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP 14404-600, Brasil. E-mail: sabryna.calazans@gmail.com Mast cell tumor is a common canine cutaneous neoplasm with variable biological behavior. Many studies in the literature evaluate predictive and prognostic factors for this neoplasm. The tumoral progression is an important phenomenon for many neoplasms, and in the canine prostatic neoplasm and squamous cell carcinoma this progression is well defined, however, don’t have a classic describe in the cutaneous canine mast cell tumors. This study reports the diagnostic and treatment assessment of cutaneous mast cell tumor in a dog presenting tumor progression. A five years old Shar Pei dog, male, 20 kg, was admitted to the veterinary clinic presenting chronic alopecia and pruritus and cutaneous nodules in left pelvic limb. The tumor was surgically excised and histopathological and immunohistochemistry examination diagnosed a low grade of mast cell tumor, membrane localization of c-KIT (KIT I) and ki-67 under 23 cells, in five high magnification fields. The tumor recurred five months after initial diagnostic presenting a nodule in the surgical region. After cytological examination, mast cell tumor was confirmed and, cytoreductive chemotherapy was started. The patient presented no response to treatment and new nodules arrised, so surgical resection was performed. Histopathological and immunohistochemistry examination was performed again demonstrating tumor progression as high grade mast cell tumor, citoplasmatic localization in c-KIT (KIT III) and ki-67 superior 23 cells. After surgical procedure, tyrosine kinase inhibitors therapy was started, but twenty days after the patient presented adverse effects and died. The mast cell tumors are common in Shar Pei dogs, by which histopathological and immunohistochemistry examinations should be considered as prognostic factors. Recurrent or metastatic mast cell tumors can show more aggressive patterns regarding primary tumors, wherefore clinical monitoring is very important during disease in these patients.O mastocitoma é a neoplasia cutânea mais comum em cães e apresenta comportamento biológico variável. Muitos trabalhos na literatura buscam definir marcadores prognósticos e preditivos para esta neoplasia, no entanto, apesar dos avanços obtidos nos últimos anos é difícil predizer recidivas e metástases deste tumor. A progressão tumoral também é um aspecto importante para as diversas neoplasias, e em neoplasias prostáticas caninas e no carcinoma de células escamosas essa progressão é bem definida, no entanto, em relação ao mastocitoma cutâneo canino não há uma descrição clássica dessa progressão. Devido à importância dessa neoplasia em cães, o presente trabalho descreve a conduta diagnóstica e abordagem terapêutica de um caso de mastocitoma cutâneo canino com progressão do grau histológico. Um cão da raça Shar-pei, cinco anos de idade, não castrado, pesando 20 kg, foi encaminhado para atendimento, com histórico de alopecia e prurido crônico, apresentando nódulo localizado em membro pélvico esquerdo. O nódulo foi retirado cirurgicamente e o material foi encaminhado ao exame histopatoló- gico e imunoistoquímico revelando mastocitoma de baixo grau, marcação membranosa de c-kit (KIT I) e proliferação celular (ki-67) menor que 23 células, contadas em cinco campos de grande aumento. Cinco meses após diagnóstico inicial, o animal retornou apresentando nódulo aderido e localizado na ferida cirúrgica. Após diagnóstico de mastocitoma através do exame citológico, iniciou-se quimioterapia objetivando citorredução, no entanto, notou-se crescimento tumoral. Como a tentativa de redução tumoral não foi satisfatória e surgiram novos nódulos, optou-se por realizar retirada cirúrgica. Em nova avaliação histopatológica e imunoistoquímica, verificou-se progressão tumoral, com diagnóstico de mastocitoma de alto grau, marcação citoplasmática de c-kit (KIT III) e proliferação celular (ki-67) maior que 23 células. Após o procedimento cirúrgico, houve recidiva tumoral e iniciou- -se protocolo terapêutico com inibidor de tirosina quinase. Nos primeiros dias o paciente tolerou bem a medicação, mas sem resposta clínica e, 20 dias após início do tratamento, apresentou efeitos adversos evoluindo para óbito. Os mastocitomas são neoplasias comuns nos cães da raça Shar-Pei, pelos quais os exames histopatológicos e imunoistoquí- micos devem ser cautelosamente avaliados como fatores prognósticos. Mastocitomas recidivantes ou mestastáticos podem apresentar padrões mais agressivos em relação ao tumor primário, fazendo- -se necessário o acompanhamento clínico durante a evolução da doença nos pacientes acometidos por esta neoplasiaSociedade de Medicina Veterinária do Estado do Rio de Janeiro.2016-06-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rbmv.org/BJVM/article/view/224Brazilian Journal of Veterinary Medicine; Vol. 38 No. 2 (2016); 147-152Revista Brasileira de Medicina Veterinária; v. 38 n. 2 (2016); 147-1522527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVporhttps://rbmv.org/BJVM/article/view/224/147Calazans, Sabryna GouveiaAlves, Carlos Eduardo FonsecaRodrigues, Paula CavaMagalhães, Georgia Modéinfo:eu-repo/semantics/openAccess2020-12-23T17:26:02Zoai:ojs.rbmv.org:article/224Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:26:02Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report Mastocitoma cutâneo canino, com progressão de baixo grau para alto grau -Relato de caso |
title |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report |
spellingShingle |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report Calazans, Sabryna Gouveia Canino c-kit ki-6 neoplasias cutâneas progressão tumoral Canine c-kit ki-67 mast cell tumor |
title_short |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report |
title_full |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report |
title_fullStr |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report |
title_full_unstemmed |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report |
title_sort |
Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report |
author |
Calazans, Sabryna Gouveia |
author_facet |
Calazans, Sabryna Gouveia Alves, Carlos Eduardo Fonseca Rodrigues, Paula Cava Magalhães, Georgia Modé |
author_role |
author |
author2 |
Alves, Carlos Eduardo Fonseca Rodrigues, Paula Cava Magalhães, Georgia Modé |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Calazans, Sabryna Gouveia Alves, Carlos Eduardo Fonseca Rodrigues, Paula Cava Magalhães, Georgia Modé |
dc.subject.por.fl_str_mv |
Canino c-kit ki-6 neoplasias cutâneas progressão tumoral Canine c-kit ki-67 mast cell tumor |
topic |
Canino c-kit ki-6 neoplasias cutâneas progressão tumoral Canine c-kit ki-67 mast cell tumor |
description |
ABSTRACT. Calazans S.G., Fonseca-Alves C.E., Rodrigues P.C. & Magalhães G.M. [Canine cutaneous mast cell tumor, with progression of low-grade to high-grade - Case report.] Mastocitoma cutâneo canino, com progressão de baixo grau para alto grau - Relato de caso. Revista Brasileira de Medicina Veterinária, 38(2):147-152, 2016. Curso de Medicina Veterinária, Universidade de Franca, Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP 14404-600, Brasil. E-mail: sabryna.calazans@gmail.com Mast cell tumor is a common canine cutaneous neoplasm with variable biological behavior. Many studies in the literature evaluate predictive and prognostic factors for this neoplasm. The tumoral progression is an important phenomenon for many neoplasms, and in the canine prostatic neoplasm and squamous cell carcinoma this progression is well defined, however, don’t have a classic describe in the cutaneous canine mast cell tumors. This study reports the diagnostic and treatment assessment of cutaneous mast cell tumor in a dog presenting tumor progression. A five years old Shar Pei dog, male, 20 kg, was admitted to the veterinary clinic presenting chronic alopecia and pruritus and cutaneous nodules in left pelvic limb. The tumor was surgically excised and histopathological and immunohistochemistry examination diagnosed a low grade of mast cell tumor, membrane localization of c-KIT (KIT I) and ki-67 under 23 cells, in five high magnification fields. The tumor recurred five months after initial diagnostic presenting a nodule in the surgical region. After cytological examination, mast cell tumor was confirmed and, cytoreductive chemotherapy was started. The patient presented no response to treatment and new nodules arrised, so surgical resection was performed. Histopathological and immunohistochemistry examination was performed again demonstrating tumor progression as high grade mast cell tumor, citoplasmatic localization in c-KIT (KIT III) and ki-67 superior 23 cells. After surgical procedure, tyrosine kinase inhibitors therapy was started, but twenty days after the patient presented adverse effects and died. The mast cell tumors are common in Shar Pei dogs, by which histopathological and immunohistochemistry examinations should be considered as prognostic factors. Recurrent or metastatic mast cell tumors can show more aggressive patterns regarding primary tumors, wherefore clinical monitoring is very important during disease in these patients. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/224 |
url |
https://rbmv.org/BJVM/article/view/224 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/224/147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 38 No. 2 (2016); 147-152 Revista Brasileira de Medicina Veterinária; v. 38 n. 2 (2016); 147-152 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
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1798313106976276480 |