Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy

Detalhes bibliográficos
Autor(a) principal: de Lima, Marcos Paulo Antunes
Data de Publicação: 2016
Outros Autores: Comassetto, Felipe, Regalin, Doughlas, Dallabrida, Ademar Luiz, Ronchi, Samuel Jorge, Oleskovicz, Nilson
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Veterinary Medicine
Texto Completo: https://rbmv.org/BJVM/article/view/109
Resumo: ABSTRACT. de Lima M.P.A., Comassetto F., Regalin D., Dallabrida A.L., Ronchi S.J. & Oleskovicz N. [Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy.] Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia. Revista Brasileira de Medicina Veterinária, 38(3):250-256, 2016. Departamento de Medicina Veteriná- ria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC 88520-000, Brasil. E-mail: noleskovicz@yahoo.com.br The sheep stands out for being a great experimental model in the orthopedic area. Thus, the aim of this study was to evaluate the safety and efficacy of the anesthetic maintenance by continuous infusion of propofol or midazolam associated with spinal anesthesia with morphine and ropivacaine in sheep underwent bilateral tibial osteotomy. Twelve healthy sheep, with an average weight of 30.5±2.7 kg were used. The animals were sedated with 0.3 mg.Kg-1 of morphine IM associated with 20 mcg.Kg-1 of detomidine IV. Then they were allocated into two groups: Midazolam group (GMID), which were induced with ketamine 5 mg.Kg-1 and midazolam 0.5 mg.Kg-1 IV, and anesthetic maintenance being performed by continuous infusion of 0 7 mg.Kg-1.h-1 of midazolam; Propofol group (GPRO), which were induced to anesthesia with 4 mg.Kg-1 propofol and maintained with its own infusion at a rate of 0.25 mg.Kg-1.min-1. The animals were intubated and maintained on spontaneous ventilation with 100% oxygen. Spinal anesthesia was performed with 0.5 mg.Kg-1 of 0.75% ropivacaine combined with 0.1 mg.Kg-1 of morphine, diluted with NaCl 0.9% solution to total volume of 1mL/7.5Kg. Significant respiratory depression after anesthesia induction was characterized by significantly increased levels of CO2 and reduced pH in both groups. A significant reduction in heart rate of about 38% after sedation with morphine and detomidine, which remained low until the end of the rating being significantly lower in the GMID. There was no requirement for supplementation during the surgery, and the animals were kept in a shallow anesthesia. We conclude that the use of propofol or midazolam, promoted adequate anesthesia with minimal cardiovascular changes, though occurring with significant respiratory depression.
id SBMV-1_d14862c6ad7dbd72582fb1a9cbab8db9
oai_identifier_str oai:ojs.rbmv.org:article/109
network_acronym_str SBMV-1
network_name_str Brazilian Journal of Veterinary Medicine
repository_id_str
spelling Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomyInfusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbiaAnestesia total intravenosamidazolampropofolovelhaTotal intravenous anesthesiamidazolampropofolsheepABSTRACT. de Lima M.P.A., Comassetto F., Regalin D., Dallabrida A.L., Ronchi S.J. & Oleskovicz N. [Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy.] Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia. Revista Brasileira de Medicina Veterinária, 38(3):250-256, 2016. Departamento de Medicina Veteriná- ria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC 88520-000, Brasil. E-mail: noleskovicz@yahoo.com.br The sheep stands out for being a great experimental model in the orthopedic area. Thus, the aim of this study was to evaluate the safety and efficacy of the anesthetic maintenance by continuous infusion of propofol or midazolam associated with spinal anesthesia with morphine and ropivacaine in sheep underwent bilateral tibial osteotomy. Twelve healthy sheep, with an average weight of 30.5±2.7 kg were used. The animals were sedated with 0.3 mg.Kg-1 of morphine IM associated with 20 mcg.Kg-1 of detomidine IV. Then they were allocated into two groups: Midazolam group (GMID), which were induced with ketamine 5 mg.Kg-1 and midazolam 0.5 mg.Kg-1 IV, and anesthetic maintenance being performed by continuous infusion of 0 7 mg.Kg-1.h-1 of midazolam; Propofol group (GPRO), which were induced to anesthesia with 4 mg.Kg-1 propofol and maintained with its own infusion at a rate of 0.25 mg.Kg-1.min-1. The animals were intubated and maintained on spontaneous ventilation with 100% oxygen. Spinal anesthesia was performed with 0.5 mg.Kg-1 of 0.75% ropivacaine combined with 0.1 mg.Kg-1 of morphine, diluted with NaCl 0.9% solution to total volume of 1mL/7.5Kg. Significant respiratory depression after anesthesia induction was characterized by significantly increased levels of CO2 and reduced pH in both groups. A significant reduction in heart rate of about 38% after sedation with morphine and detomidine, which remained low until the end of the rating being significantly lower in the GMID. There was no requirement for supplementation during the surgery, and the animals were kept in a shallow anesthesia. We conclude that the use of propofol or midazolam, promoted adequate anesthesia with minimal cardiovascular changes, though occurring with significant respiratory depression.A espécie ovina destaca-se por ser um ótimo modelo experimental na área ortopédica. Desta forma, o objetivo deste estudo foi avaliar a segurança e eficácia da manutenção anestésica por infusão contínua de propofol ou midazolam, associada à anestesia subaracnóidea com morfina e ropivacaína, em ovinos, submetidos à osteotomia bilateral de tíbia. Foram utilizados 12 ovinos, mestiços, hígidos com peso médio de 30,5±2,7 Kg. Os animais foram sedados com 0,3 mg.Kg-1 de morfina IM associado a 20 mcg.K-1 detomidina IV. Posteriormente foram alocados em dois grupos: grupo Midazolam (GMID), onde foram induzidos à anestesia geral com 5 mg.Kg-1 cetamina e 0,5 mg.Kg-1 midazolam IV, sendo a manutenção anestésica realizada através da infusão contínua de 0,7 mg.Kg- -1.h-1 de midazolam; Grupo Propofol (GPRO), onde foram induzidos à anestesia geral com 4 mg.Kg-1 propofol, e manutenção anestésica através de sua infusão continua na taxa de 0,25 mg.Kg-1.min-1. Os animais foram intubados e mantidos em ventila- ção espontânea com oxigênio 100%. Realizou-se anestesia subaracnóidea com 0,5 mg.Kg-1 de ropivacaína 0,75% associado a 0,1 mg.Kg-1 de morfina pela via subaracnóidea, diluindo-se com solução NaCl 0,9%, para um volume final de 1 mL/7,5 Kg. Houve depressão respiratória significativa após a indução anestésica, caracterizada pela elevação significativa dos níveis de CO2 e redução do pH, em ambos os grupos. Observou-se redução significativa da FC em torno de 38% após a sedação com morfina e detomidina, a qual manteve-se reduzida até o final da avalição, sendo significativamente menor no GMID. Não houve requerimento de suplementação analgésica durante o trans cirúrgico/ anestésico, sendo que os animais foram mantidos em plano anestésico superficial. Conclui-se que a utilização de propofol ou midazolam, nas doses propostas, promoveu plano anestésico adequado, com alterações cardiovasculares mínimas, embora cursando com depressão respiratória significativa.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2016-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/109Brazilian Journal of Veterinary Medicine; Vol. 38 No. 3 (2016); 250-256Revista Brasileira de Medicina Veterinária; v. 38 n. 3 (2016); 250-2562527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVporhttps://rbmv.org/BJVM/article/view/109/56de Lima, Marcos Paulo AntunesComassetto, FelipeRegalin, DoughlasDallabrida, Ademar LuizRonchi, Samuel JorgeOleskovicz, Nilsoninfo:eu-repo/semantics/openAccess2020-12-23T17:25:48Zoai:ojs.rbmv.org:article/109Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:25:48Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false
dc.title.none.fl_str_mv Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia
title Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
spellingShingle Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
de Lima, Marcos Paulo Antunes
Anestesia total intravenosa
midazolam
propofol
ovelha
Total intravenous anesthesia
midazolam
propofol
sheep
title_short Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
title_full Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
title_fullStr Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
title_full_unstemmed Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
title_sort Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
author de Lima, Marcos Paulo Antunes
author_facet de Lima, Marcos Paulo Antunes
Comassetto, Felipe
Regalin, Doughlas
Dallabrida, Ademar Luiz
Ronchi, Samuel Jorge
Oleskovicz, Nilson
author_role author
author2 Comassetto, Felipe
Regalin, Doughlas
Dallabrida, Ademar Luiz
Ronchi, Samuel Jorge
Oleskovicz, Nilson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv de Lima, Marcos Paulo Antunes
Comassetto, Felipe
Regalin, Doughlas
Dallabrida, Ademar Luiz
Ronchi, Samuel Jorge
Oleskovicz, Nilson
dc.subject.por.fl_str_mv Anestesia total intravenosa
midazolam
propofol
ovelha
Total intravenous anesthesia
midazolam
propofol
sheep
topic Anestesia total intravenosa
midazolam
propofol
ovelha
Total intravenous anesthesia
midazolam
propofol
sheep
description ABSTRACT. de Lima M.P.A., Comassetto F., Regalin D., Dallabrida A.L., Ronchi S.J. & Oleskovicz N. [Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy.] Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia. Revista Brasileira de Medicina Veterinária, 38(3):250-256, 2016. Departamento de Medicina Veteriná- ria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC 88520-000, Brasil. E-mail: noleskovicz@yahoo.com.br The sheep stands out for being a great experimental model in the orthopedic area. Thus, the aim of this study was to evaluate the safety and efficacy of the anesthetic maintenance by continuous infusion of propofol or midazolam associated with spinal anesthesia with morphine and ropivacaine in sheep underwent bilateral tibial osteotomy. Twelve healthy sheep, with an average weight of 30.5±2.7 kg were used. The animals were sedated with 0.3 mg.Kg-1 of morphine IM associated with 20 mcg.Kg-1 of detomidine IV. Then they were allocated into two groups: Midazolam group (GMID), which were induced with ketamine 5 mg.Kg-1 and midazolam 0.5 mg.Kg-1 IV, and anesthetic maintenance being performed by continuous infusion of 0 7 mg.Kg-1.h-1 of midazolam; Propofol group (GPRO), which were induced to anesthesia with 4 mg.Kg-1 propofol and maintained with its own infusion at a rate of 0.25 mg.Kg-1.min-1. The animals were intubated and maintained on spontaneous ventilation with 100% oxygen. Spinal anesthesia was performed with 0.5 mg.Kg-1 of 0.75% ropivacaine combined with 0.1 mg.Kg-1 of morphine, diluted with NaCl 0.9% solution to total volume of 1mL/7.5Kg. Significant respiratory depression after anesthesia induction was characterized by significantly increased levels of CO2 and reduced pH in both groups. A significant reduction in heart rate of about 38% after sedation with morphine and detomidine, which remained low until the end of the rating being significantly lower in the GMID. There was no requirement for supplementation during the surgery, and the animals were kept in a shallow anesthesia. We conclude that the use of propofol or midazolam, promoted adequate anesthesia with minimal cardiovascular changes, though occurring with significant respiratory depression.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer reviewed
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbmv.org/BJVM/article/view/109
url https://rbmv.org/BJVM/article/view/109
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbmv.org/BJVM/article/view/109/56
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Medicine; Vol. 38 No. 3 (2016); 250-256
Revista Brasileira de Medicina Veterinária; v. 38 n. 3 (2016); 250-256
2527-2179
0100-2430
reponame:Brazilian Journal of Veterinary Medicine
instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron:SBMV
instname_str Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron_str SBMV
institution SBMV
reponame_str Brazilian Journal of Veterinary Medicine
collection Brazilian Journal of Veterinary Medicine
repository.name.fl_str_mv Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
repository.mail.fl_str_mv contato.rbmv@gmail.com
_version_ 1798313106389073920