Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/109 |
Resumo: | ABSTRACT. de Lima M.P.A., Comassetto F., Regalin D., Dallabrida A.L., Ronchi S.J. & Oleskovicz N. [Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy.] Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia. Revista Brasileira de Medicina Veterinária, 38(3):250-256, 2016. Departamento de Medicina Veteriná- ria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC 88520-000, Brasil. E-mail: noleskovicz@yahoo.com.br The sheep stands out for being a great experimental model in the orthopedic area. Thus, the aim of this study was to evaluate the safety and efficacy of the anesthetic maintenance by continuous infusion of propofol or midazolam associated with spinal anesthesia with morphine and ropivacaine in sheep underwent bilateral tibial osteotomy. Twelve healthy sheep, with an average weight of 30.5±2.7 kg were used. The animals were sedated with 0.3 mg.Kg-1 of morphine IM associated with 20 mcg.Kg-1 of detomidine IV. Then they were allocated into two groups: Midazolam group (GMID), which were induced with ketamine 5 mg.Kg-1 and midazolam 0.5 mg.Kg-1 IV, and anesthetic maintenance being performed by continuous infusion of 0 7 mg.Kg-1.h-1 of midazolam; Propofol group (GPRO), which were induced to anesthesia with 4 mg.Kg-1 propofol and maintained with its own infusion at a rate of 0.25 mg.Kg-1.min-1. The animals were intubated and maintained on spontaneous ventilation with 100% oxygen. Spinal anesthesia was performed with 0.5 mg.Kg-1 of 0.75% ropivacaine combined with 0.1 mg.Kg-1 of morphine, diluted with NaCl 0.9% solution to total volume of 1mL/7.5Kg. Significant respiratory depression after anesthesia induction was characterized by significantly increased levels of CO2 and reduced pH in both groups. A significant reduction in heart rate of about 38% after sedation with morphine and detomidine, which remained low until the end of the rating being significantly lower in the GMID. There was no requirement for supplementation during the surgery, and the animals were kept in a shallow anesthesia. We conclude that the use of propofol or midazolam, promoted adequate anesthesia with minimal cardiovascular changes, though occurring with significant respiratory depression. |
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Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomyInfusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbiaAnestesia total intravenosamidazolampropofolovelhaTotal intravenous anesthesiamidazolampropofolsheepABSTRACT. de Lima M.P.A., Comassetto F., Regalin D., Dallabrida A.L., Ronchi S.J. & Oleskovicz N. [Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy.] Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia. Revista Brasileira de Medicina Veterinária, 38(3):250-256, 2016. Departamento de Medicina Veteriná- ria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC 88520-000, Brasil. E-mail: noleskovicz@yahoo.com.br The sheep stands out for being a great experimental model in the orthopedic area. Thus, the aim of this study was to evaluate the safety and efficacy of the anesthetic maintenance by continuous infusion of propofol or midazolam associated with spinal anesthesia with morphine and ropivacaine in sheep underwent bilateral tibial osteotomy. Twelve healthy sheep, with an average weight of 30.5±2.7 kg were used. The animals were sedated with 0.3 mg.Kg-1 of morphine IM associated with 20 mcg.Kg-1 of detomidine IV. Then they were allocated into two groups: Midazolam group (GMID), which were induced with ketamine 5 mg.Kg-1 and midazolam 0.5 mg.Kg-1 IV, and anesthetic maintenance being performed by continuous infusion of 0 7 mg.Kg-1.h-1 of midazolam; Propofol group (GPRO), which were induced to anesthesia with 4 mg.Kg-1 propofol and maintained with its own infusion at a rate of 0.25 mg.Kg-1.min-1. The animals were intubated and maintained on spontaneous ventilation with 100% oxygen. Spinal anesthesia was performed with 0.5 mg.Kg-1 of 0.75% ropivacaine combined with 0.1 mg.Kg-1 of morphine, diluted with NaCl 0.9% solution to total volume of 1mL/7.5Kg. Significant respiratory depression after anesthesia induction was characterized by significantly increased levels of CO2 and reduced pH in both groups. A significant reduction in heart rate of about 38% after sedation with morphine and detomidine, which remained low until the end of the rating being significantly lower in the GMID. There was no requirement for supplementation during the surgery, and the animals were kept in a shallow anesthesia. We conclude that the use of propofol or midazolam, promoted adequate anesthesia with minimal cardiovascular changes, though occurring with significant respiratory depression.A espécie ovina destaca-se por ser um ótimo modelo experimental na área ortopédica. Desta forma, o objetivo deste estudo foi avaliar a segurança e eficácia da manutenção anestésica por infusão contínua de propofol ou midazolam, associada à anestesia subaracnóidea com morfina e ropivacaína, em ovinos, submetidos à osteotomia bilateral de tíbia. Foram utilizados 12 ovinos, mestiços, hígidos com peso médio de 30,5±2,7 Kg. Os animais foram sedados com 0,3 mg.Kg-1 de morfina IM associado a 20 mcg.K-1 detomidina IV. Posteriormente foram alocados em dois grupos: grupo Midazolam (GMID), onde foram induzidos à anestesia geral com 5 mg.Kg-1 cetamina e 0,5 mg.Kg-1 midazolam IV, sendo a manutenção anestésica realizada através da infusão contínua de 0,7 mg.Kg- -1.h-1 de midazolam; Grupo Propofol (GPRO), onde foram induzidos à anestesia geral com 4 mg.Kg-1 propofol, e manutenção anestésica através de sua infusão continua na taxa de 0,25 mg.Kg-1.min-1. Os animais foram intubados e mantidos em ventila- ção espontânea com oxigênio 100%. Realizou-se anestesia subaracnóidea com 0,5 mg.Kg-1 de ropivacaína 0,75% associado a 0,1 mg.Kg-1 de morfina pela via subaracnóidea, diluindo-se com solução NaCl 0,9%, para um volume final de 1 mL/7,5 Kg. Houve depressão respiratória significativa após a indução anestésica, caracterizada pela elevação significativa dos níveis de CO2 e redução do pH, em ambos os grupos. Observou-se redução significativa da FC em torno de 38% após a sedação com morfina e detomidina, a qual manteve-se reduzida até o final da avalição, sendo significativamente menor no GMID. Não houve requerimento de suplementação analgésica durante o trans cirúrgico/ anestésico, sendo que os animais foram mantidos em plano anestésico superficial. Conclui-se que a utilização de propofol ou midazolam, nas doses propostas, promoveu plano anestésico adequado, com alterações cardiovasculares mínimas, embora cursando com depressão respiratória significativa.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2016-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/109Brazilian Journal of Veterinary Medicine; Vol. 38 No. 3 (2016); 250-256Revista Brasileira de Medicina Veterinária; v. 38 n. 3 (2016); 250-2562527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVporhttps://rbmv.org/BJVM/article/view/109/56de Lima, Marcos Paulo AntunesComassetto, FelipeRegalin, DoughlasDallabrida, Ademar LuizRonchi, Samuel JorgeOleskovicz, Nilsoninfo:eu-repo/semantics/openAccess2020-12-23T17:25:48Zoai:ojs.rbmv.org:article/109Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:25:48Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia |
title |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy |
spellingShingle |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy de Lima, Marcos Paulo Antunes Anestesia total intravenosa midazolam propofol ovelha Total intravenous anesthesia midazolam propofol sheep |
title_short |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy |
title_full |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy |
title_fullStr |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy |
title_full_unstemmed |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy |
title_sort |
Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy |
author |
de Lima, Marcos Paulo Antunes |
author_facet |
de Lima, Marcos Paulo Antunes Comassetto, Felipe Regalin, Doughlas Dallabrida, Ademar Luiz Ronchi, Samuel Jorge Oleskovicz, Nilson |
author_role |
author |
author2 |
Comassetto, Felipe Regalin, Doughlas Dallabrida, Ademar Luiz Ronchi, Samuel Jorge Oleskovicz, Nilson |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
de Lima, Marcos Paulo Antunes Comassetto, Felipe Regalin, Doughlas Dallabrida, Ademar Luiz Ronchi, Samuel Jorge Oleskovicz, Nilson |
dc.subject.por.fl_str_mv |
Anestesia total intravenosa midazolam propofol ovelha Total intravenous anesthesia midazolam propofol sheep |
topic |
Anestesia total intravenosa midazolam propofol ovelha Total intravenous anesthesia midazolam propofol sheep |
description |
ABSTRACT. de Lima M.P.A., Comassetto F., Regalin D., Dallabrida A.L., Ronchi S.J. & Oleskovicz N. [Propofol or midazolam infusion associated with subarachnoid anaesthesia in sheep submitted to bilateral tibial osteotomy.] Infusão contínua de propofol ou midazolam associado à anestesia subaracnóidea em ovinos submetidos a osteotomia bilateral de tíbia. Revista Brasileira de Medicina Veterinária, 38(3):250-256, 2016. Departamento de Medicina Veteriná- ria, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Av. Luís de Camões, 2090, Conta Dinheiro, Lages, SC 88520-000, Brasil. E-mail: noleskovicz@yahoo.com.br The sheep stands out for being a great experimental model in the orthopedic area. Thus, the aim of this study was to evaluate the safety and efficacy of the anesthetic maintenance by continuous infusion of propofol or midazolam associated with spinal anesthesia with morphine and ropivacaine in sheep underwent bilateral tibial osteotomy. Twelve healthy sheep, with an average weight of 30.5±2.7 kg were used. The animals were sedated with 0.3 mg.Kg-1 of morphine IM associated with 20 mcg.Kg-1 of detomidine IV. Then they were allocated into two groups: Midazolam group (GMID), which were induced with ketamine 5 mg.Kg-1 and midazolam 0.5 mg.Kg-1 IV, and anesthetic maintenance being performed by continuous infusion of 0 7 mg.Kg-1.h-1 of midazolam; Propofol group (GPRO), which were induced to anesthesia with 4 mg.Kg-1 propofol and maintained with its own infusion at a rate of 0.25 mg.Kg-1.min-1. The animals were intubated and maintained on spontaneous ventilation with 100% oxygen. Spinal anesthesia was performed with 0.5 mg.Kg-1 of 0.75% ropivacaine combined with 0.1 mg.Kg-1 of morphine, diluted with NaCl 0.9% solution to total volume of 1mL/7.5Kg. Significant respiratory depression after anesthesia induction was characterized by significantly increased levels of CO2 and reduced pH in both groups. A significant reduction in heart rate of about 38% after sedation with morphine and detomidine, which remained low until the end of the rating being significantly lower in the GMID. There was no requirement for supplementation during the surgery, and the animals were kept in a shallow anesthesia. We conclude that the use of propofol or midazolam, promoted adequate anesthesia with minimal cardiovascular changes, though occurring with significant respiratory depression. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/109 |
url |
https://rbmv.org/BJVM/article/view/109 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/109/56 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 38 No. 3 (2016); 250-256 Revista Brasileira de Medicina Veterinária; v. 38 n. 3 (2016); 250-256 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313106389073920 |