Feline congenital hypothyroidism: a case report
Main Author: | |
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Publication Date: | 2023 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Brazilian Journal of Veterinary Medicine |
Download full: | https://bjvm.org.br/BJVM/article/view/1304 |
Summary: | We report a two-month-old male cat weighing 630 grams with congenital hypothyroidism. The main complaints were difficulty defecating for more than three days and prostration. Physical examination revealed a broad, flat face, a short neck, enlarged submandibular lymph nodes, chemosis, mild bilateral mucopurulent ocular discharge, seborrheic coat, with gingival thickening around the upper and lower deciduous incisor teeth with partial eruption. The abdomen was distended due to constipation and right unilateral cryptorchidism. Based on this, feline congenital hypothyroidism was suspected. Hormonal tests (free T4 by equilibrium dialysis of 0.06 ng/dl, total T4 of 0.1 ng/ml and TSH of 4.7 ng/ml) confirmed this. Treatment was started with levothyroxine sodium (5-32.2 µg/kg/day). After 120 days of treatment, there was clinical stabilization. Then the patient underwent orchiectomy of the left and of the right ectopic testicles, and at 380 days of treatment, the thyroid scintigraphy showed intense uptake of the radiopharmaceutical by both thyroid lobes and a significant increase in volume. Clinical evaluation showed weight gain (2.6 kilograms during treatment), improvement in the shape of the skull, and a notable increase in body size. At 17 months of age, hormone values were within the reference limits after administration of levothyroxine sodium (32.2µg/kg/day). |
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Feline congenital hypothyroidism: a case reportHipotiroidismo congênito felino: relato de casoscintigraphy, endocrinology, cat, levothyroxine, thyroid.cintilografia, endocrinologia, gato, levotiroxina, tireoideWe report a two-month-old male cat weighing 630 grams with congenital hypothyroidism. The main complaints were difficulty defecating for more than three days and prostration. Physical examination revealed a broad, flat face, a short neck, enlarged submandibular lymph nodes, chemosis, mild bilateral mucopurulent ocular discharge, seborrheic coat, with gingival thickening around the upper and lower deciduous incisor teeth with partial eruption. The abdomen was distended due to constipation and right unilateral cryptorchidism. Based on this, feline congenital hypothyroidism was suspected. Hormonal tests (free T4 by equilibrium dialysis of 0.06 ng/dl, total T4 of 0.1 ng/ml and TSH of 4.7 ng/ml) confirmed this. Treatment was started with levothyroxine sodium (5-32.2 µg/kg/day). After 120 days of treatment, there was clinical stabilization. Then the patient underwent orchiectomy of the left and of the right ectopic testicles, and at 380 days of treatment, the thyroid scintigraphy showed intense uptake of the radiopharmaceutical by both thyroid lobes and a significant increase in volume. Clinical evaluation showed weight gain (2.6 kilograms during treatment), improvement in the shape of the skull, and a notable increase in body size. At 17 months of age, hormone values were within the reference limits after administration of levothyroxine sodium (32.2µg/kg/day).O objetivo deste trabalho foi relatar o caso de hipotireoidismo congênito em um felino, macho, pelo curto brasileiro (PCB), com dois meses de idade, pesando 630 gramas. Apresentava como queixa principal dificuldade para defecar por mais de três dias e prostração. O exame físico geral constatou face larga e plana, pescoço curto, linfonodos submandibulares aumentados, quemose e discreta secreção ocular mucopurulenta bilateral. A pelagem apresentava-se opaca e seborreica, espessamento gengival em torno dos dentes decíduos incisivos superiores e inferiores com parcial erupção. À palpação, o abdômen apresentava-se distendido pela presença de fezes em cólon e criptorquidismo unilateral direito. Diante das alterações supracitadas, suspeitou-se de hipotireoidismo congênito felino. O qual foi confirmado através de exames complementares hormonais específicos (T4 livre por diálise do equilíbrio 0,06 ng/dl, T4 total 0,1 ng/ml e TSH 4,7 ng/ml). Iniciou-se o tratamento com levotiroxina sódica na dose de 5 a 32,2µg/kg/dia. Com 120 dias de tratamento houve estabilização clínica e então o paciente foi submetido à orquiectomia dos testículos esquerdo ectópico e direito. E aos 380 dias de tratamento ao exame de cintilografia de tireoide onde foi evidenciado intensa captação do radiofármaco por ambos os lobos tireoidianos e importante aumento de volume. Na avaliação clínica, foi observado ganho de peso (2,6 quilogramas ao longo do tratamento), melhora na conformação do crânio e notável aumento de tamanho corporal. Aos 17 meses de idade, os valores hormonais se encontravam dentro dos limites de referência, após a administração da dose de lexotiroxina sódica na dose de 32,2µg/kg/dia.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2023-11-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://bjvm.org.br/BJVM/article/view/130410.29374/2527-2179.bjvm003423Brazilian Journal of Veterinary Medicine; Vol. 45 (2023); e003423Revista Brasileira de Medicina Veterinária; v. 45 (2023); e0034232527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://bjvm.org.br/BJVM/article/view/1304/1353https://bjvm.org.br/BJVM/article/view/1304/1363Copyright (c) 2023 Gabriella Carvalho Abend, Stephanie Favato de Azevedo, Arthur Saturiano dos Santos, Gustavo Carvalho Cobucci, Heloisa Justen Moreira de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAbend, Gabriella Carvalhode Azevedo, Stephanie Favatodos Santos, Arthur SaturianoCobucci, Gustavo Carvalhode Souza, Heloisa Justen Moreira2023-12-15T23:52:37Zoai:ojs.rbmv.org:article/1304Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2023-12-15T23:52:37Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Feline congenital hypothyroidism: a case report Hipotiroidismo congênito felino: relato de caso |
title |
Feline congenital hypothyroidism: a case report |
spellingShingle |
Feline congenital hypothyroidism: a case report Abend, Gabriella Carvalho scintigraphy, endocrinology, cat, levothyroxine, thyroid. cintilografia, endocrinologia, gato, levotiroxina, tireoide |
title_short |
Feline congenital hypothyroidism: a case report |
title_full |
Feline congenital hypothyroidism: a case report |
title_fullStr |
Feline congenital hypothyroidism: a case report |
title_full_unstemmed |
Feline congenital hypothyroidism: a case report |
title_sort |
Feline congenital hypothyroidism: a case report |
author |
Abend, Gabriella Carvalho |
author_facet |
Abend, Gabriella Carvalho de Azevedo, Stephanie Favato dos Santos, Arthur Saturiano Cobucci, Gustavo Carvalho de Souza, Heloisa Justen Moreira |
author_role |
author |
author2 |
de Azevedo, Stephanie Favato dos Santos, Arthur Saturiano Cobucci, Gustavo Carvalho de Souza, Heloisa Justen Moreira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Abend, Gabriella Carvalho de Azevedo, Stephanie Favato dos Santos, Arthur Saturiano Cobucci, Gustavo Carvalho de Souza, Heloisa Justen Moreira |
dc.subject.por.fl_str_mv |
scintigraphy, endocrinology, cat, levothyroxine, thyroid. cintilografia, endocrinologia, gato, levotiroxina, tireoide |
topic |
scintigraphy, endocrinology, cat, levothyroxine, thyroid. cintilografia, endocrinologia, gato, levotiroxina, tireoide |
description |
We report a two-month-old male cat weighing 630 grams with congenital hypothyroidism. The main complaints were difficulty defecating for more than three days and prostration. Physical examination revealed a broad, flat face, a short neck, enlarged submandibular lymph nodes, chemosis, mild bilateral mucopurulent ocular discharge, seborrheic coat, with gingival thickening around the upper and lower deciduous incisor teeth with partial eruption. The abdomen was distended due to constipation and right unilateral cryptorchidism. Based on this, feline congenital hypothyroidism was suspected. Hormonal tests (free T4 by equilibrium dialysis of 0.06 ng/dl, total T4 of 0.1 ng/ml and TSH of 4.7 ng/ml) confirmed this. Treatment was started with levothyroxine sodium (5-32.2 µg/kg/day). After 120 days of treatment, there was clinical stabilization. Then the patient underwent orchiectomy of the left and of the right ectopic testicles, and at 380 days of treatment, the thyroid scintigraphy showed intense uptake of the radiopharmaceutical by both thyroid lobes and a significant increase in volume. Clinical evaluation showed weight gain (2.6 kilograms during treatment), improvement in the shape of the skull, and a notable increase in body size. At 17 months of age, hormone values were within the reference limits after administration of levothyroxine sodium (32.2µg/kg/day). |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjvm.org.br/BJVM/article/view/1304 10.29374/2527-2179.bjvm003423 |
url |
https://bjvm.org.br/BJVM/article/view/1304 |
identifier_str_mv |
10.29374/2527-2179.bjvm003423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://bjvm.org.br/BJVM/article/view/1304/1353 https://bjvm.org.br/BJVM/article/view/1304/1363 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/xml |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 45 (2023); e003423 Revista Brasileira de Medicina Veterinária; v. 45 (2023); e003423 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
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1798313106229690368 |