Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/1053 |
Resumo: | Ketamine and dexmedetomidine are analgesic drugs indicated to control surgical pain. This study analyzes the increase in cortisol and blood glucose levels in bitches undergoing continuous infusion of dexmedetomidine and ketamine in ovariosalpingohisterectomy. For that, we compared groups using these drugs with a group using FLK (fentanyl, lidocaine, and ketamine) and the control group (without transsurgical analgesia). The experiment included 40 young (3.8 ± 2.8 years) mixed-breed bitches with average body weight of 9.8 ± 2.4 kg. These animals were allocated into 5 groups according to the recommended anesthetic technique: GCO (control group for pain); GFLK (control group for analgesia), undergoing continuous infusion of fentanyl (50 μg/mL), lidocaine (150 mg), and ketamine (30 mg), or FLK diluted in 500 mL of 0.9% saline solution and infused, after fentanyl bolus (5 μg/kg), at a rate of 10 mg/kg/h, equivalent to: 0.03 μg/kg/min of fentanyl associated with 50 μg/kg/min of lidocaine and 10 μg/kg/min of ketamine, about 5 minutes before surgical incision; GCE, undergoing infusion of only ketamine at the time of surgery, at a rate of 10 μg/kg/min, after intravenous administration of this drug at 2 mg/kg; GDEX, undergoing infusion of dexmedetomidine (2 μg/kg diluted in 20 mL of 0.9% NaCl), starting with an infusion of 2 μg/kg for 5 minutes, followed by an infusion rate of 2 μg/kg/h; GDEXCE, which received dexmedetomidine bolus (2 μg/kg) plus ketamine (2 mg/kg diluted in 20 mL of 0.9% NaCl solution), intravenously, over a period of five minutes. Then, the alpha-2 agonist (diluted in 20 mL of 0.9% NaCl) was infused at a rate of 2 μg/kg/h, and ketamine was continuously infused at 10 μg/kg/min. The results showed a significant reduction of cortisol levels of animals in the GDEXCE group in comparison to the animals in the GCO group at moment 5 (M5). However, cortisol and blood glucose values after extubation were influenced by the action of drugs. Thus, cortisol and blood glucose are not considered effective parameters for assessing transsurgical stress in bitches submitted to ovariosalpingohisterectomy and anesthetized with dexmedetomidine plus ketamine. Considering hemodynamic and behavioral parameters, dexmedetomidine associated with ketamine reduced the surgical stress of animals in the GDEXCE group. |
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Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidineAvaliação do estresse transcirúrgico em cadelas submetidas à ovariosalpingohisterectomia sob infusões de fentanil, lidocaína e de cetamina, associada ou não à dexmedetomidinaanalgesiaalpha 2-agonistsN-methyl-D-aspartateanalgesiaalpha 2-agonistasN-metil-D-aspartatoKetamine and dexmedetomidine are analgesic drugs indicated to control surgical pain. This study analyzes the increase in cortisol and blood glucose levels in bitches undergoing continuous infusion of dexmedetomidine and ketamine in ovariosalpingohisterectomy. For that, we compared groups using these drugs with a group using FLK (fentanyl, lidocaine, and ketamine) and the control group (without transsurgical analgesia). The experiment included 40 young (3.8 ± 2.8 years) mixed-breed bitches with average body weight of 9.8 ± 2.4 kg. These animals were allocated into 5 groups according to the recommended anesthetic technique: GCO (control group for pain); GFLK (control group for analgesia), undergoing continuous infusion of fentanyl (50 μg/mL), lidocaine (150 mg), and ketamine (30 mg), or FLK diluted in 500 mL of 0.9% saline solution and infused, after fentanyl bolus (5 μg/kg), at a rate of 10 mg/kg/h, equivalent to: 0.03 μg/kg/min of fentanyl associated with 50 μg/kg/min of lidocaine and 10 μg/kg/min of ketamine, about 5 minutes before surgical incision; GCE, undergoing infusion of only ketamine at the time of surgery, at a rate of 10 μg/kg/min, after intravenous administration of this drug at 2 mg/kg; GDEX, undergoing infusion of dexmedetomidine (2 μg/kg diluted in 20 mL of 0.9% NaCl), starting with an infusion of 2 μg/kg for 5 minutes, followed by an infusion rate of 2 μg/kg/h; GDEXCE, which received dexmedetomidine bolus (2 μg/kg) plus ketamine (2 mg/kg diluted in 20 mL of 0.9% NaCl solution), intravenously, over a period of five minutes. Then, the alpha-2 agonist (diluted in 20 mL of 0.9% NaCl) was infused at a rate of 2 μg/kg/h, and ketamine was continuously infused at 10 μg/kg/min. The results showed a significant reduction of cortisol levels of animals in the GDEXCE group in comparison to the animals in the GCO group at moment 5 (M5). However, cortisol and blood glucose values after extubation were influenced by the action of drugs. Thus, cortisol and blood glucose are not considered effective parameters for assessing transsurgical stress in bitches submitted to ovariosalpingohisterectomy and anesthetized with dexmedetomidine plus ketamine. Considering hemodynamic and behavioral parameters, dexmedetomidine associated with ketamine reduced the surgical stress of animals in the GDEXCE group.Cetamina e dexmedetomidina são fármacos com propriedades analgésicas indicados para controlar a dor cirúrgica. O objetivo deste estudo foi verificar o aumento do cortisol e glicemia através da infusão continua com dexmedetomidina e cetamina em cirurgia de ovariosalpingohisterectomia em cadelas, quando comparado ao uso do FLK (fentanil, lidocaína e cetamina) e ao grupo controle (sem analgesia transcirurgica). Para tal experimento foram utilizadas 40 cadelas jovens (3,8 ± 2,8 anos), sem raça definida, com massa corpórea média de 9,8 ± 2,4 kg. Esses animais foram alocados em 5 grupos de acordo com a técnica anestésica preconizada: o grupo GCO considerado o controle para dor; no grupo GFLK, considerado controle para analgesia, procedeu-se infusão continua de fentanil (50 μg/mL), cetamina (30 mg) e lidocaína (150 mg) ou FLK diluídos em 500 mL de solução fisiológica a 0,9% e infudidos, após bolus de fentanil na dose de 5 μg /kg, a uma taxa de 10 mg/kg/h, equivalente a: 0,03 μg/kg/min de fentanil, associados a 50 μg/kg/min de lidocaína e 10 μg/kg/min de cetamina; cerca de 5 minutos antes da incisão cirúrgica; no grupo GCE foi infundido no momento da cirurgia apenas com cetamina na dose de 10 μg/kg/min, após administração intravenosa de 2 mg/kg; no grupo GDEX, a infusão foi feita com dexmedetomidina 2 μg/kg diluída em um volume de 20 mL de NaCl 0,9%, iniciando com uma infusão de 2 μg/kg em 5 minutos, seguida de uma taxa de infusão de 2 μg/kg/h; já o grupo GDEXCE recebeu um bolus de dexmedetomidina 2 μg/kg mais cetamina 2 mg/kg diluída em 20 mL de solução de NaCl 0,9%, por via intravenosa, durante um período de cinco minutos. Na sequência, procedeu-se a infusão do alfa-2 agonista na dose de 2 μg/kg/h, diluída em 20 mL de NaCl 0,9%, mais cetamina por infusão contínua de 10 μg/kg/min. De acordo com os resultados obtidos, pôde-se verificar que houve redução significativa na dose de cortisol no M5 dos animais do grupo GDEXCE quando comparado ao grupo GCO, porém os valores de cortisol e glicemia no momento pós-extubação foram influenciados pela ação dos fármacos. Logo, o cortisol e glicemia não são considerados parâmetros eficazes para avaliação do estresse transcirúrgico em cadelas anestesiadas com dexmedetomidina mais cetamina submetidas à ovariosalpingohisterectomia; considerando os parâmetros hemodinâmicos e comportamentais, nos animais do grupo GDEXCE, a dexmedetomidina associada com cetamina reduziu o estresse cirúrgico dos animais em estudo.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/105310.29374/2527-2179.bjvm105320Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e105320Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e1053202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1053/1010Copyright (c) 2020 Kleyton Domingos de Melo, Ana Paula Monteiro Tenório, Eduardo Alberto Tudury, Mauro de Araújo Penaforte Junior, Sabrina Cândido Trajano, Maria Sheila da Silva Ferreira, Gabriela Ratis Galeas, Karine Silva Camargohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDomingos de Melo, Kleyton Monteiro Tenório, Ana Paula Tudury, Eduardo Albertode Araújo Penaforte Junior, Mauro Cândido Trajano, Sabrinada Silva Ferreira, Maria Sheila Ratis Galeas, Gabriela Silva Camargo, Karine 2021-05-13T13:46:40Zoai:ojs.rbmv.org:article/1053Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-05-13T13:46:40Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine Avaliação do estresse transcirúrgico em cadelas submetidas à ovariosalpingohisterectomia sob infusões de fentanil, lidocaína e de cetamina, associada ou não à dexmedetomidina |
title |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine |
spellingShingle |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine Domingos de Melo, Kleyton analgesia alpha 2-agonists N-methyl-D-aspartate analgesia alpha 2-agonistas N-metil-D-aspartato |
title_short |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine |
title_full |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine |
title_fullStr |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine |
title_full_unstemmed |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine |
title_sort |
Evaluation of transsurgical stress in bitches submitted to ovariosalpingohisterectomy under infusions of fentanyl, lidocaine, and ketamine, associated or not with dexmedetomidine |
author |
Domingos de Melo, Kleyton |
author_facet |
Domingos de Melo, Kleyton Monteiro Tenório, Ana Paula Tudury, Eduardo Alberto de Araújo Penaforte Junior, Mauro Cândido Trajano, Sabrina da Silva Ferreira, Maria Sheila Ratis Galeas, Gabriela Silva Camargo, Karine |
author_role |
author |
author2 |
Monteiro Tenório, Ana Paula Tudury, Eduardo Alberto de Araújo Penaforte Junior, Mauro Cândido Trajano, Sabrina da Silva Ferreira, Maria Sheila Ratis Galeas, Gabriela Silva Camargo, Karine |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Domingos de Melo, Kleyton Monteiro Tenório, Ana Paula Tudury, Eduardo Alberto de Araújo Penaforte Junior, Mauro Cândido Trajano, Sabrina da Silva Ferreira, Maria Sheila Ratis Galeas, Gabriela Silva Camargo, Karine |
dc.subject.por.fl_str_mv |
analgesia alpha 2-agonists N-methyl-D-aspartate analgesia alpha 2-agonistas N-metil-D-aspartato |
topic |
analgesia alpha 2-agonists N-methyl-D-aspartate analgesia alpha 2-agonistas N-metil-D-aspartato |
description |
Ketamine and dexmedetomidine are analgesic drugs indicated to control surgical pain. This study analyzes the increase in cortisol and blood glucose levels in bitches undergoing continuous infusion of dexmedetomidine and ketamine in ovariosalpingohisterectomy. For that, we compared groups using these drugs with a group using FLK (fentanyl, lidocaine, and ketamine) and the control group (without transsurgical analgesia). The experiment included 40 young (3.8 ± 2.8 years) mixed-breed bitches with average body weight of 9.8 ± 2.4 kg. These animals were allocated into 5 groups according to the recommended anesthetic technique: GCO (control group for pain); GFLK (control group for analgesia), undergoing continuous infusion of fentanyl (50 μg/mL), lidocaine (150 mg), and ketamine (30 mg), or FLK diluted in 500 mL of 0.9% saline solution and infused, after fentanyl bolus (5 μg/kg), at a rate of 10 mg/kg/h, equivalent to: 0.03 μg/kg/min of fentanyl associated with 50 μg/kg/min of lidocaine and 10 μg/kg/min of ketamine, about 5 minutes before surgical incision; GCE, undergoing infusion of only ketamine at the time of surgery, at a rate of 10 μg/kg/min, after intravenous administration of this drug at 2 mg/kg; GDEX, undergoing infusion of dexmedetomidine (2 μg/kg diluted in 20 mL of 0.9% NaCl), starting with an infusion of 2 μg/kg for 5 minutes, followed by an infusion rate of 2 μg/kg/h; GDEXCE, which received dexmedetomidine bolus (2 μg/kg) plus ketamine (2 mg/kg diluted in 20 mL of 0.9% NaCl solution), intravenously, over a period of five minutes. Then, the alpha-2 agonist (diluted in 20 mL of 0.9% NaCl) was infused at a rate of 2 μg/kg/h, and ketamine was continuously infused at 10 μg/kg/min. The results showed a significant reduction of cortisol levels of animals in the GDEXCE group in comparison to the animals in the GCO group at moment 5 (M5). However, cortisol and blood glucose values after extubation were influenced by the action of drugs. Thus, cortisol and blood glucose are not considered effective parameters for assessing transsurgical stress in bitches submitted to ovariosalpingohisterectomy and anesthetized with dexmedetomidine plus ketamine. Considering hemodynamic and behavioral parameters, dexmedetomidine associated with ketamine reduced the surgical stress of animals in the GDEXCE group. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/1053 10.29374/2527-2179.bjvm105320 |
url |
https://rbmv.org/BJVM/article/view/1053 |
identifier_str_mv |
10.29374/2527-2179.bjvm105320 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/1053/1010 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e105320 Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e105320 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313110611689472 |