The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/241 |
Resumo: | ABSTRACT. Ribeiro V.M.F. & Santos F.G.A. [The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu).] Alterações clínicas e anatomopatológicas produzidas por intoxicação acidental com salinomicina sódica em catetos (Tayassu tajacu). Revista Brasileira de Medicina Veterinária, 38(1):69-72, 2016. Laboratório de Apoio à Vida Silvestre, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário Rio Branco, Rodovia BR-364 Km 4, Rio Branco, AC 69920-900, Brazil. E-mail: vania.rib@uol.com.br Sodic Salinomycin is a polyester monocarboxylic antibiotic of the ionophore group. It has antibacterial and anticoccidial properties. The intoxication for ionophore antibiotics happens when there is ingestion of high doses of the drug for mistakes of calculations or contamination of rations. That work had the aims to describe the clinical and anatomopathological and histological alterations produced by the natural and accidental intoxication by sodic salinomycin (Coxystar 12% granular®) in peccaries (Tayassu tajacu). 37 animals were submitted accidentally to the ingestion ad libitum of sodic salinomycin, in the farm of wild animals “Caboclinho da Mata”, located in Experimental Finance “Catuaba” belonging to the Federal University of Acre. Of the individuals that consumed the salinomycin, 14 died in the period of 15 days after the ingestion. It was observed in the animals: anorexia, motor incordination, staggering pace, asthenia, ventral decubitus and death. One of the animals that came to death was submitted to the necropsy. Liver fragments and cardiac muscle were collected, fastened in formaldehyde to 10% and processed, and embedded in paraffin, cut at a nominal thickness of 4 µm, and stained with hematoxylin and eosin for histopathological examination. Macroscopically, indicative lesions of degenerative process were observed, in the liver, where this presented pattern evident lobular and congestion. In the heart, a bulging was observed, with dilation of the right camera, subepicardials and miocardials hemorrhages. Microscopically, in the liver, the lesions were distributed in a diffuse way by the parenchyma of the organ, with ectasia of the centrilobulares veins and hepatocytes vacuolateds. These vacuolizations had forms and varied sizes, as well as dilation of the sinusóides and discreet megalocitose, and in the heart muscle, besides vascular lesions, characterized by hiperemia and edema, any lesion was not observed in the fibers. Intoxications for salinomycin were already registered in swine, caprine, bovine, cats, alpacas, turkeys, rabbits, equine and chinchillas. The anamnesis and the clinical symptomatology presented by the animals that ingested natural and accidentally the sodic salinomycin, going to death, as well as the discoveries macro and microscopic they suggest a diagnosis of acute and sub-acute phase intoxication for antibiotic ionóforo, being these the first cases told in peccaries. |
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The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu)Alterações clínicas e anatomopatológicas produzidas por intoxicação acidental com salinomicina sódica em catetos (Tayassu tajacu)Intoxicação por salinomicina sódicacatetoTayassu tajacuionóforointoxicação acidentalanimais silvestresSodic salinomycin poisoningpeccaryTayassu tajacuionophorewild animalsABSTRACT. Ribeiro V.M.F. & Santos F.G.A. [The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu).] Alterações clínicas e anatomopatológicas produzidas por intoxicação acidental com salinomicina sódica em catetos (Tayassu tajacu). Revista Brasileira de Medicina Veterinária, 38(1):69-72, 2016. Laboratório de Apoio à Vida Silvestre, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário Rio Branco, Rodovia BR-364 Km 4, Rio Branco, AC 69920-900, Brazil. E-mail: vania.rib@uol.com.br Sodic Salinomycin is a polyester monocarboxylic antibiotic of the ionophore group. It has antibacterial and anticoccidial properties. The intoxication for ionophore antibiotics happens when there is ingestion of high doses of the drug for mistakes of calculations or contamination of rations. That work had the aims to describe the clinical and anatomopathological and histological alterations produced by the natural and accidental intoxication by sodic salinomycin (Coxystar 12% granular®) in peccaries (Tayassu tajacu). 37 animals were submitted accidentally to the ingestion ad libitum of sodic salinomycin, in the farm of wild animals “Caboclinho da Mata”, located in Experimental Finance “Catuaba” belonging to the Federal University of Acre. Of the individuals that consumed the salinomycin, 14 died in the period of 15 days after the ingestion. It was observed in the animals: anorexia, motor incordination, staggering pace, asthenia, ventral decubitus and death. One of the animals that came to death was submitted to the necropsy. Liver fragments and cardiac muscle were collected, fastened in formaldehyde to 10% and processed, and embedded in paraffin, cut at a nominal thickness of 4 µm, and stained with hematoxylin and eosin for histopathological examination. Macroscopically, indicative lesions of degenerative process were observed, in the liver, where this presented pattern evident lobular and congestion. In the heart, a bulging was observed, with dilation of the right camera, subepicardials and miocardials hemorrhages. Microscopically, in the liver, the lesions were distributed in a diffuse way by the parenchyma of the organ, with ectasia of the centrilobulares veins and hepatocytes vacuolateds. These vacuolizations had forms and varied sizes, as well as dilation of the sinusóides and discreet megalocitose, and in the heart muscle, besides vascular lesions, characterized by hiperemia and edema, any lesion was not observed in the fibers. Intoxications for salinomycin were already registered in swine, caprine, bovine, cats, alpacas, turkeys, rabbits, equine and chinchillas. The anamnesis and the clinical symptomatology presented by the animals that ingested natural and accidentally the sodic salinomycin, going to death, as well as the discoveries macro and microscopic they suggest a diagnosis of acute and sub-acute phase intoxication for antibiotic ionóforo, being these the first cases told in peccaries.Salinomicina sódica é um antibiótico poliéster monocarboxílico do grupo ionóforo. Tem propriedades antimicrobianas e anticoccídicas. A intoxicação por antibióticos ionóforos ocorre quando há ingestão de altas doses da droga por erros de cálculos ou contaminação de rações. Esse trabalho teve como objetivo descrever as alterações clínicas e anatomohistopatológicas produzidas pela intoxicação natural e acidental por salinomicina sódica (Coxystar 12% granular®) em catetos (Tayassu tajacu). 37 animais foram submetidos acidentalmente à ingestão “ad libitum” de salinomicina sódica, no criatório de animais silvestres “Caboclinho da Mata”, situado na Fazenda Experimental Catuaba pertencente à Universidade Federal do Acre. Dos indivíduos que consumiram a salinomicina, 14 morreram no período de 15 dias após a ingestão. Foi observado nos animais: anorexia, incoordena- ção motora, andar cambaleante, astenia, decúbito ventral e morte. Um dos animais que veio a óbito foi submetido à necropsia. Fragmentos de fígado e músculo estriado cardíaco foram coletados, fixados em formol a 10% e rotineiramente processados, pela técnica de embebição em parafina. Após serem cortados a 4μm, foram corados com hematoxilina e eosina. Macroscopicamente, foram observadas lesões indicativas de processo degenerativo, no fígado, onde este apresentava padrão lobular evidente e congestão. No coração, observou-se um abaulamento, com dilatação da câmara direita, hemorragias subepicárdicas e miocárdicas. Microscopicamente, no fígado, as lesões estavam distribu- ídas de forma difusa pelo parênquima do órgão, com ectasia das veias centros-lobulares e hepatócitos vacuolados. Estas vacuolizações tinham formas e tamanhos variados, assim como dilatação dos sinusóides e discreta megalocitose. No músculo cardíaco, além de lesões vasculares, caracterizadas por hiperemia e edema, não se observou nenhuma lesão nas fibras. Intoxicações por salinomicina ja foram registradas em suinos, caprinos, bovinos, gatos, alpacas, perus, coelhos, equinos e chinchilas. A anamnese e a sintomatologia clínica apresentadas pelos animais que ingeriram natural e acidentalmente a salinomicina sódica, indo a óbito, assim como os achados macro e microscópicos sugerem um diagnóstico de intoxicação aguda/sub-aguda por antibiótico ionóforo, sendo estes os primeiros casos relatados em catetos.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2016-03-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/24110.2430/00000000000000Brazilian Journal of Veterinary Medicine; Vol. 38 No. 1 (2016); 69-72Revista Brasileira de Medicina Veterinária; v. 38 n. 1 (2016); 69-722527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVporhttps://rbmv.org/BJVM/article/view/241/162Ribeiro, Vânia Maria FrançaSantos, Francisco Glauco de Araújoinfo:eu-repo/semantics/openAccess2020-12-23T17:26:24Zoai:ojs.rbmv.org:article/241Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:26:24Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) Alterações clínicas e anatomopatológicas produzidas por intoxicação acidental com salinomicina sódica em catetos (Tayassu tajacu) |
title |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) |
spellingShingle |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) Ribeiro, Vânia Maria França Intoxicação por salinomicina sódica cateto Tayassu tajacu ionóforo intoxicação acidental animais silvestres Sodic salinomycin poisoning peccary Tayassu tajacu ionophore wild animals |
title_short |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) |
title_full |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) |
title_fullStr |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) |
title_full_unstemmed |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) |
title_sort |
The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu) |
author |
Ribeiro, Vânia Maria França |
author_facet |
Ribeiro, Vânia Maria França Santos, Francisco Glauco de Araújo |
author_role |
author |
author2 |
Santos, Francisco Glauco de Araújo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Ribeiro, Vânia Maria França Santos, Francisco Glauco de Araújo |
dc.subject.por.fl_str_mv |
Intoxicação por salinomicina sódica cateto Tayassu tajacu ionóforo intoxicação acidental animais silvestres Sodic salinomycin poisoning peccary Tayassu tajacu ionophore wild animals |
topic |
Intoxicação por salinomicina sódica cateto Tayassu tajacu ionóforo intoxicação acidental animais silvestres Sodic salinomycin poisoning peccary Tayassu tajacu ionophore wild animals |
description |
ABSTRACT. Ribeiro V.M.F. & Santos F.G.A. [The clinical and anatomopathological and histologic alterations produced by the natural and accidental poisoning by sodic salinomycin in peccaries (Tayassu tajacu).] Alterações clínicas e anatomopatológicas produzidas por intoxicação acidental com salinomicina sódica em catetos (Tayassu tajacu). Revista Brasileira de Medicina Veterinária, 38(1):69-72, 2016. Laboratório de Apoio à Vida Silvestre, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário Rio Branco, Rodovia BR-364 Km 4, Rio Branco, AC 69920-900, Brazil. E-mail: vania.rib@uol.com.br Sodic Salinomycin is a polyester monocarboxylic antibiotic of the ionophore group. It has antibacterial and anticoccidial properties. The intoxication for ionophore antibiotics happens when there is ingestion of high doses of the drug for mistakes of calculations or contamination of rations. That work had the aims to describe the clinical and anatomopathological and histological alterations produced by the natural and accidental intoxication by sodic salinomycin (Coxystar 12% granular®) in peccaries (Tayassu tajacu). 37 animals were submitted accidentally to the ingestion ad libitum of sodic salinomycin, in the farm of wild animals “Caboclinho da Mata”, located in Experimental Finance “Catuaba” belonging to the Federal University of Acre. Of the individuals that consumed the salinomycin, 14 died in the period of 15 days after the ingestion. It was observed in the animals: anorexia, motor incordination, staggering pace, asthenia, ventral decubitus and death. One of the animals that came to death was submitted to the necropsy. Liver fragments and cardiac muscle were collected, fastened in formaldehyde to 10% and processed, and embedded in paraffin, cut at a nominal thickness of 4 µm, and stained with hematoxylin and eosin for histopathological examination. Macroscopically, indicative lesions of degenerative process were observed, in the liver, where this presented pattern evident lobular and congestion. In the heart, a bulging was observed, with dilation of the right camera, subepicardials and miocardials hemorrhages. Microscopically, in the liver, the lesions were distributed in a diffuse way by the parenchyma of the organ, with ectasia of the centrilobulares veins and hepatocytes vacuolateds. These vacuolizations had forms and varied sizes, as well as dilation of the sinusóides and discreet megalocitose, and in the heart muscle, besides vascular lesions, characterized by hiperemia and edema, any lesion was not observed in the fibers. Intoxications for salinomycin were already registered in swine, caprine, bovine, cats, alpacas, turkeys, rabbits, equine and chinchillas. The anamnesis and the clinical symptomatology presented by the animals that ingested natural and accidentally the sodic salinomycin, going to death, as well as the discoveries macro and microscopic they suggest a diagnosis of acute and sub-acute phase intoxication for antibiotic ionóforo, being these the first cases told in peccaries. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/241 10.2430/00000000000000 |
url |
https://rbmv.org/BJVM/article/view/241 |
identifier_str_mv |
10.2430/00000000000000 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/241/162 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 38 No. 1 (2016); 69-72 Revista Brasileira de Medicina Veterinária; v. 38 n. 1 (2016); 69-72 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
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1798313107002490880 |