Detomidine and xylazine, at different doses, in donkeys (Equus asinus)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/1008 |
Resumo: | The effects of detomidine and xylazine in northeasters donkeys were compared. Six animals participated, randomly, of all experimental groups: xylazine 10%, 0.8 mg/kg (xylazine group 0.8 - GX0.8), 1.0 mg/kg (GX1.0) and 1, 2 mg/kg (GX1.2); and detomidine 1%, 0.02 mg/kg (Detomidine group 0.02 - GD0.02), 0.04 mg/kg (GD0.04) and 0.06 mg/kg (GD0.06) intravenous. Heart rate (HR) and respiratory rate (RR), rectal temperature (RT), mean arterial pressure (MAP), blood glucose, sedation, analgesia, ataxia, arrhythmias and urination were monitored. Duration of sedation was greater in the groups in which detomidine was administered. The muzzle-soil distance significantly reduced in all groups five minutes after the sedative administration, remaining smaller for a longer time in the GD0.06. Ataxia in GX1.0 was greater than in GX0.08 and GX1,2, being equivalent to GD0,04 and GD0,06. Analgesia lasted 30 minutes in GD0.06 and 10 minutes in the others. There was reduction of HR in GD0.02 and GD0.04 and atrioventricular block. There was a reduction in TR in GX1,2, GD0.02, GD0,04 and GD0,06. RR decreased in all groups. MAP increased in GD0.02, GD0.04 and GD0.06 five, 20, 30 and 10 minutes after administration of detomidine, respectively. Hyperglycaemia occurred for 120 minutes in all animals receiving detomidine. The frequency of micturition was higher in GD0.06 (2.2 ± 0.8) than in GX0.8 (0.8 ± 0.4). In northern Brazil, detomidine and xylazine promote short duration analgesia and cardiorespiratory alterations, but detomidine causes a greater sedative, hypertensive and hypothermic effect. |
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Detomidine and xylazine, at different doses, in donkeys (Equus asinus)Detomidina e xilazina, em diferentes doses, em asininos (Equus asinus)agonista alfa-2 adrenérgicoanalgesiaequídeossedaçãoalpha-2 adrenergic agonistanalgesiaequinesedationThe effects of detomidine and xylazine in northeasters donkeys were compared. Six animals participated, randomly, of all experimental groups: xylazine 10%, 0.8 mg/kg (xylazine group 0.8 - GX0.8), 1.0 mg/kg (GX1.0) and 1, 2 mg/kg (GX1.2); and detomidine 1%, 0.02 mg/kg (Detomidine group 0.02 - GD0.02), 0.04 mg/kg (GD0.04) and 0.06 mg/kg (GD0.06) intravenous. Heart rate (HR) and respiratory rate (RR), rectal temperature (RT), mean arterial pressure (MAP), blood glucose, sedation, analgesia, ataxia, arrhythmias and urination were monitored. Duration of sedation was greater in the groups in which detomidine was administered. The muzzle-soil distance significantly reduced in all groups five minutes after the sedative administration, remaining smaller for a longer time in the GD0.06. Ataxia in GX1.0 was greater than in GX0.08 and GX1,2, being equivalent to GD0,04 and GD0,06. Analgesia lasted 30 minutes in GD0.06 and 10 minutes in the others. There was reduction of HR in GD0.02 and GD0.04 and atrioventricular block. There was a reduction in TR in GX1,2, GD0.02, GD0,04 and GD0,06. RR decreased in all groups. MAP increased in GD0.02, GD0.04 and GD0.06 five, 20, 30 and 10 minutes after administration of detomidine, respectively. Hyperglycaemia occurred for 120 minutes in all animals receiving detomidine. The frequency of micturition was higher in GD0.06 (2.2 ± 0.8) than in GX0.8 (0.8 ± 0.4). In northern Brazil, detomidine and xylazine promote short duration analgesia and cardiorespiratory alterations, but detomidine causes a greater sedative, hypertensive and hypothermic effect.Compararam-se os efeitos da detomidina e da xilazina em asininos. Foram utilizados, aleatoriamente, seis animais, os quais participaram de seis grupos experimentais: xilazina 10%, 0,8 mg/kg (Grupo xilazina 0,8 - GX0,8), 1,0 mg/kg (GX1,0) e 1,2 mg/kg (GX1,2); e detomidina 1%, 20 µg/kg (Grupo detomidina 20 – GD20), 40 µg/kg (GD40) e 60 µg/kg (GD60), administrados por via intravenosa. Foram monitorados: frequências cardíaca (FC) e respiratória (FR), temperatura retal (TR), pressão arterial média (PAM), glicemia, sedação, analgesia, ataxia, arritmias e micção. Duração da sedação foi maior nos grupos nos quais foi administrada detomidina, durando, em média, 140 minutos no GD60 e 47 minutos no GX1,2. Analgesia durou 30 minutos no GD60 e apenas 10 minutos nos demais grupos em que se utilizou a detomidina e nos grupos da xilazina. Ocorreu redução da FC no GD20 e no GD40 e bloqueio atrioventricular. Ocorreu redução na TR em GX1,2, GD20, GD40 e GD60. A FR diminuiu em todos os grupos. A PAM aumentou no GD20, GD40 e GD60 cinco, 20, 30 e 10 minutos após a administração da detomidina, respectivamente. Ocorreu hiperglicemia por 120 minutos em todos os animais que receberam detomidina. A frequência de micções foi maior no GD60 (2,2 ± 0,8) que no GX0,8 (0,8 ± 0,4). Em asininos, a detomidina e a xilazina promovem analgesia de curta duração e discretas alterações cardiorrespiratórias, havendo segurança e eficácia com as doses utilizadas.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/100810.29374/2527-2179.bjvm100820Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e100820Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e1008202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1008/980Copyright (c) 2020 Fernanda Vieira Henrique, Roberta Nunes Parentoni, Arthur Willian de Lima Brasil, Rafaela Alves Dias, Ana Lucélia de Araújo Araújo, Rodrigo de Souza Mendes, Emanuel Ferreira Martins Filho, João Moreira da Costa Neto, Almir Pereira de Souza, Pedro Isidro da Nóbrega Netohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessParentoni, Roberta NunesHenrique, Fernanda VieiraBrasil, Arthur Willian de LimaDias, Rafaela AlvesAraújo, Ana Lucélia de AraújoMendes, Rodrigo de SouzaMartins Filho, Emanuel FerreiraCosta Neto, João Moreira dade Souza, Almir Pereirada Nóbrega Neto, Pedro Isidro2021-05-13T13:46:40Zoai:ojs.rbmv.org:article/1008Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-05-13T13:46:40Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) Detomidina e xilazina, em diferentes doses, em asininos (Equus asinus) |
title |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) |
spellingShingle |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) Parentoni, Roberta Nunes agonista alfa-2 adrenérgico analgesia equídeos sedação alpha-2 adrenergic agonist analgesia equine sedation |
title_short |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) |
title_full |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) |
title_fullStr |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) |
title_full_unstemmed |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) |
title_sort |
Detomidine and xylazine, at different doses, in donkeys (Equus asinus) |
author |
Parentoni, Roberta Nunes |
author_facet |
Parentoni, Roberta Nunes Henrique, Fernanda Vieira Brasil, Arthur Willian de Lima Dias, Rafaela Alves Araújo, Ana Lucélia de Araújo Mendes, Rodrigo de Souza Martins Filho, Emanuel Ferreira Costa Neto, João Moreira da de Souza, Almir Pereira da Nóbrega Neto, Pedro Isidro |
author_role |
author |
author2 |
Henrique, Fernanda Vieira Brasil, Arthur Willian de Lima Dias, Rafaela Alves Araújo, Ana Lucélia de Araújo Mendes, Rodrigo de Souza Martins Filho, Emanuel Ferreira Costa Neto, João Moreira da de Souza, Almir Pereira da Nóbrega Neto, Pedro Isidro |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Parentoni, Roberta Nunes Henrique, Fernanda Vieira Brasil, Arthur Willian de Lima Dias, Rafaela Alves Araújo, Ana Lucélia de Araújo Mendes, Rodrigo de Souza Martins Filho, Emanuel Ferreira Costa Neto, João Moreira da de Souza, Almir Pereira da Nóbrega Neto, Pedro Isidro |
dc.subject.por.fl_str_mv |
agonista alfa-2 adrenérgico analgesia equídeos sedação alpha-2 adrenergic agonist analgesia equine sedation |
topic |
agonista alfa-2 adrenérgico analgesia equídeos sedação alpha-2 adrenergic agonist analgesia equine sedation |
description |
The effects of detomidine and xylazine in northeasters donkeys were compared. Six animals participated, randomly, of all experimental groups: xylazine 10%, 0.8 mg/kg (xylazine group 0.8 - GX0.8), 1.0 mg/kg (GX1.0) and 1, 2 mg/kg (GX1.2); and detomidine 1%, 0.02 mg/kg (Detomidine group 0.02 - GD0.02), 0.04 mg/kg (GD0.04) and 0.06 mg/kg (GD0.06) intravenous. Heart rate (HR) and respiratory rate (RR), rectal temperature (RT), mean arterial pressure (MAP), blood glucose, sedation, analgesia, ataxia, arrhythmias and urination were monitored. Duration of sedation was greater in the groups in which detomidine was administered. The muzzle-soil distance significantly reduced in all groups five minutes after the sedative administration, remaining smaller for a longer time in the GD0.06. Ataxia in GX1.0 was greater than in GX0.08 and GX1,2, being equivalent to GD0,04 and GD0,06. Analgesia lasted 30 minutes in GD0.06 and 10 minutes in the others. There was reduction of HR in GD0.02 and GD0.04 and atrioventricular block. There was a reduction in TR in GX1,2, GD0.02, GD0,04 and GD0,06. RR decreased in all groups. MAP increased in GD0.02, GD0.04 and GD0.06 five, 20, 30 and 10 minutes after administration of detomidine, respectively. Hyperglycaemia occurred for 120 minutes in all animals receiving detomidine. The frequency of micturition was higher in GD0.06 (2.2 ± 0.8) than in GX0.8 (0.8 ± 0.4). In northern Brazil, detomidine and xylazine promote short duration analgesia and cardiorespiratory alterations, but detomidine causes a greater sedative, hypertensive and hypothermic effect. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/1008 10.29374/2527-2179.bjvm100820 |
url |
https://rbmv.org/BJVM/article/view/1008 |
identifier_str_mv |
10.29374/2527-2179.bjvm100820 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/1008/980 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e100820 Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e100820 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313110555066368 |