Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals

Detalhes bibliográficos
Autor(a) principal: Mancilha Carneiro, Daniele
Data de Publicação: 2021
Outros Autores: Espíndula Mendonça, Camilla, Rosa, Maurílio, Monnerat Nogueira, Denise, de Lima, Leonardo Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Medicine
Texto Completo: https://rbmv.org/BJVM/article/view/1062
Resumo: The report describes two cases of four- and five-month-old Mangalarga Marchador fillies showing signs of night blindness. The animals appeared to have disorientation at night. Ophthalmic examination revealed all parameters as normal except for the absence of menace response in the penumbra. Fundoscopy examination did not demonstrate any morphological abnormalities in the retina. Electroretinography examination confirmed a failure in the electrical activity of rods, which are retinal photoreceptors responsible for night vision. However, we noted a small reduction in the electrical activity of the cones, suggesting that the animals may have visual difficulties in clear environments. Genomic analysis of the hair follicles from their mane (Veterinary Genetics Laboratory/UC – Davis, USA) did not reveal the presence of homozygosity for the Leopard Complex, a gene pool associated with congenital stationary nocturnal blindness (CSNB) in horses with depigmented hair. Outcomes of the studbook analysis suggested the presence of kinship among the described animals. Additional research is required for the genomic determination of nocturnal blindness in Mangalarga Marchador horses. 
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spelling Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foalsCegueira noturna congênita em potros da raça Mangalarga Marchador não associada ao Complexo do Leopardocavalogenéticaraça brasileiravisãoeletrorretinografiahorsegeneticsbrazilian racevisionelectroretinographyThe report describes two cases of four- and five-month-old Mangalarga Marchador fillies showing signs of night blindness. The animals appeared to have disorientation at night. Ophthalmic examination revealed all parameters as normal except for the absence of menace response in the penumbra. Fundoscopy examination did not demonstrate any morphological abnormalities in the retina. Electroretinography examination confirmed a failure in the electrical activity of rods, which are retinal photoreceptors responsible for night vision. However, we noted a small reduction in the electrical activity of the cones, suggesting that the animals may have visual difficulties in clear environments. Genomic analysis of the hair follicles from their mane (Veterinary Genetics Laboratory/UC – Davis, USA) did not reveal the presence of homozygosity for the Leopard Complex, a gene pool associated with congenital stationary nocturnal blindness (CSNB) in horses with depigmented hair. Outcomes of the studbook analysis suggested the presence of kinship among the described animals. Additional research is required for the genomic determination of nocturnal blindness in Mangalarga Marchador horses. Objetivou-se relatar dois casos clínicos de potras com 4 e 5 meses de idade da raça Mangalarga Marchador, demonstrando sinais de cegueira noturna. Os animais apresentavam histórico de desorientação no período noturno. No exame oftálmico, todos os parâmetros foram normais, exceto pela ausência de reflexo de ameaça na penumbra. A fundoscopia não demonstrou nenhuma anormalidade morfológica da retina. A eletrorretinografia confirmou falha na atividade elétrica dos bastonetes, fotorreceptores da retina responsáveis pela visão noturna. No entanto, percebeu-se também uma pequena redução da atividade elétrica dos cones, demonstrando que os animais podem ter uma dificuldade visual em ambientes claros. O exame genômico dos folículos pilosos (Veterinary Genetics Laboratory/UC – Davis, USA) não demonstrou homozigose para Complexo do Leopardo, conjunto de genes associado à cegueira noturna estacionária congênita (CSNB) em cavalos com pelagem despigmentada. A análise genealógica demonstrou um parentesco em comum entre os animais descritos. Assim, tornam-se necessárias pesquisas adicionais para determinação genômica da cegueira noturna em equinos da raça Mangalarga Marchador.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rbmv.org/BJVM/article/view/106210.29374/2179.bjvm106220Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e106220Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e1062202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1062/985Copyright (c) 2020 Daniele Mancilha Carneiro, Camilla Espíndula Mendonça, Maurílio Rosa, Denise Monnerat Nogueira, Leonardo Rodrigues de Limahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMancilha Carneiro, Daniele Espíndula Mendonça, Camilla Rosa, MaurílioMonnerat Nogueira, Denise de Lima, Leonardo Rodrigues2021-05-13T13:46:40Zoai:ojs.rbmv.org:article/1062Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-05-13T13:46:40Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false
dc.title.none.fl_str_mv Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
Cegueira noturna congênita em potros da raça Mangalarga Marchador não associada ao Complexo do Leopardo
title Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
spellingShingle Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
Mancilha Carneiro, Daniele
cavalo
genética
raça brasileira
visão
eletrorretinografia
horse
genetics
brazilian race
vision
electroretinography
title_short Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
title_full Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
title_fullStr Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
title_full_unstemmed Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
title_sort Complex Leopard non-associated congenital night blindness in Mangalarga Marchador foals
author Mancilha Carneiro, Daniele
author_facet Mancilha Carneiro, Daniele
Espíndula Mendonça, Camilla
Rosa, Maurílio
Monnerat Nogueira, Denise
de Lima, Leonardo Rodrigues
author_role author
author2 Espíndula Mendonça, Camilla
Rosa, Maurílio
Monnerat Nogueira, Denise
de Lima, Leonardo Rodrigues
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mancilha Carneiro, Daniele
Espíndula Mendonça, Camilla
Rosa, Maurílio
Monnerat Nogueira, Denise
de Lima, Leonardo Rodrigues
dc.subject.por.fl_str_mv cavalo
genética
raça brasileira
visão
eletrorretinografia
horse
genetics
brazilian race
vision
electroretinography
topic cavalo
genética
raça brasileira
visão
eletrorretinografia
horse
genetics
brazilian race
vision
electroretinography
description The report describes two cases of four- and five-month-old Mangalarga Marchador fillies showing signs of night blindness. The animals appeared to have disorientation at night. Ophthalmic examination revealed all parameters as normal except for the absence of menace response in the penumbra. Fundoscopy examination did not demonstrate any morphological abnormalities in the retina. Electroretinography examination confirmed a failure in the electrical activity of rods, which are retinal photoreceptors responsible for night vision. However, we noted a small reduction in the electrical activity of the cones, suggesting that the animals may have visual difficulties in clear environments. Genomic analysis of the hair follicles from their mane (Veterinary Genetics Laboratory/UC – Davis, USA) did not reveal the presence of homozygosity for the Leopard Complex, a gene pool associated with congenital stationary nocturnal blindness (CSNB) in horses with depigmented hair. Outcomes of the studbook analysis suggested the presence of kinship among the described animals. Additional research is required for the genomic determination of nocturnal blindness in Mangalarga Marchador horses. 
publishDate 2021
dc.date.none.fl_str_mv 2021-05-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbmv.org/BJVM/article/view/1062
10.29374/2179.bjvm106220
url https://rbmv.org/BJVM/article/view/1062
identifier_str_mv 10.29374/2179.bjvm106220
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbmv.org/BJVM/article/view/1062/985
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e106220
Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e106220
2527-2179
0100-2430
reponame:Brazilian Journal of Veterinary Medicine
instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron:SBMV
instname_str Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron_str SBMV
institution SBMV
reponame_str Brazilian Journal of Veterinary Medicine
collection Brazilian Journal of Veterinary Medicine
repository.name.fl_str_mv Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
repository.mail.fl_str_mv contato.rbmv@gmail.com
_version_ 1798313110623223808

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