Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Medicine |
Texto Completo: | https://rbmv.org/BJVM/article/view/1253 |
Resumo: | This randomized clinical trial aimed to evaluate different fluid therapy protocols associated with inhalational or total intravenous anesthesia in the cardiorespiratory stability of bitches with sepsis subjected to a surgical procedure to control the infectious focus. Thirty-two bitches diagnosed with pyometra and sepsis and treated at the University Veterinary Hospital between 2018 and 2019 were recruited. After admission, diagnosis, clinical, and laboratory evaluation, patients were randomly distributed into the following groups: propofol 5 (P[5]: preoperative restrictive fluid therapy–5mL/kg/h and intravenous general anesthesia); propofol 10 (P[10]: preoperative liberal fluid therapy–10mL/kg/h and intravenous general anesthesia); and isoflurane 5 (I[5]: preoperative restrictive fluid therapy–5mL/kg/h and inhalational general anesthesia). Lactate on admission (LAC1) and release (LAC2), heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), rectal temperature (RT), oxygen saturation (SpO2 ), and carbon dioxide extraction rate (EtCO2 ) were analyzed at PRE, T10, T20, T30, T40, T50, TEXT, and TDIS. Clearance of 20% of lactate occurred in 18 dogs, with the P[10] group displaying the best performance. There was no statistical difference in vasopressor requirements among the groups. Liberal fluid therapy showed greater cardiovascular stability than restrictive therapy in the perioperative period. Regarding general anesthesia, isoflurane showed greater cardiorespiratory stability than propofol during anesthetic maintenance. In conclusion, although the three proposed protocols are safe and there is no difference in their superiority, some observed changes may be relevant and considered when it is possible to individualize the therapy for the patient. |
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Brazilian Journal of Veterinary Medicine |
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Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsisComparação de protocolos de fluidoterapia pré-operatória associados a anestesia inalatória ou total intravenosa para procedimentos anestésicos em cães com sepsebitches, pyometra, cardiovascular stability, organ dysfunction, arterial hypotensioncadelas, piometra, estabilidade cardiovascular, disfunção orgânica, hipotensão arterial.This randomized clinical trial aimed to evaluate different fluid therapy protocols associated with inhalational or total intravenous anesthesia in the cardiorespiratory stability of bitches with sepsis subjected to a surgical procedure to control the infectious focus. Thirty-two bitches diagnosed with pyometra and sepsis and treated at the University Veterinary Hospital between 2018 and 2019 were recruited. After admission, diagnosis, clinical, and laboratory evaluation, patients were randomly distributed into the following groups: propofol 5 (P[5]: preoperative restrictive fluid therapy–5mL/kg/h and intravenous general anesthesia); propofol 10 (P[10]: preoperative liberal fluid therapy–10mL/kg/h and intravenous general anesthesia); and isoflurane 5 (I[5]: preoperative restrictive fluid therapy–5mL/kg/h and inhalational general anesthesia). Lactate on admission (LAC1) and release (LAC2), heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), rectal temperature (RT), oxygen saturation (SpO2 ), and carbon dioxide extraction rate (EtCO2 ) were analyzed at PRE, T10, T20, T30, T40, T50, TEXT, and TDIS. Clearance of 20% of lactate occurred in 18 dogs, with the P[10] group displaying the best performance. There was no statistical difference in vasopressor requirements among the groups. Liberal fluid therapy showed greater cardiovascular stability than restrictive therapy in the perioperative period. Regarding general anesthesia, isoflurane showed greater cardiorespiratory stability than propofol during anesthetic maintenance. In conclusion, although the three proposed protocols are safe and there is no difference in their superiority, some observed changes may be relevant and considered when it is possible to individualize the therapy for the patient.Este ensaio clínico randomizado teve a proposição de avaliar diferentes protocolos de fluidoterapia associados a anestesia inalatória ou total intravenosa, na estabilidade hemodinâmica de cadelas com sepse, submetidas a procedimento cirúrgico, para controle do foco infeccioso. Foram incluídas trinta e duas cadelas, com diagnóstico de piometra e sepse, atendidas em hospital veterinário universitário, no período de 2018 a 2019. Após admissão, diagnóstico, avaliação clínica e laboratoriais, os pacientes foram distribuídos de maneira aleatória nos grupos Propofol 5 (P[5]: fluidoterapia restritiva pré-operatória - 5mL/kg/h e anestesia geral intravenosa), Propofol 10 (P[10]: fluidoterapia liberal pré-operatória - 10mL/kg/h e anestesia geral intravenosa) e Isoflurano 5 (I[5]: fluidoterapia restritiva pré-operatória - 5mL/kg/h e anestesia geral inalatória). Foram analisados lactato na admissão (LAC1) e liberação (LAC2), frequências cardíacas (HR) e respiratória (RR), pressão arterial sistólica (SBP), temperatura retal (RT), saturação de oxigênio (SpO2 ) e taxa de extração de dióxido de carbono (EtCO2 ) nos seguintes momentos: PRE, T10, T20, T30, T40, T50, TEXT e TDIS. A depuração de 20% do lactato ocorreu em 18 cães, tendo o grupo P[10] o melhor desempenho. Não houve diferença estatística no requerimento de vasopressores entre os grupos. A fluidoterapia liberal apresentou maior estabilidade cardiovascular quando comparado com a restritiva no período perioperatório. Com relação a anestesia geral, o isoflurano apresentou maior estabilidade cardiorrespiratória que o propofol na manutenção anestésica. Nós concluímos que apesar de os três protocolos propostos serem seguros e sem diferença em superioridade entre eles, algumas alterações observadas podem ser relevantes e ponderadas quando for possível a individualização da terapêutica no paciente.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2022-08-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdftext/xmlhttps://rbmv.org/BJVM/article/view/125310.29374/2527-2179.bjvm001222Brazilian Journal of Veterinary Medicine; Vol. 44 (2022); e001222Revista Brasileira de Medicina Veterinária; v. 44 (2022); e0012222527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1253/1249https://rbmv.org/BJVM/article/view/1253/1258Copyright (c) 2022 Vírgínia Conceição Tavares Lima, Ana Julia Rodrigues Peixoto, Maria Eduarda dos Santos Lopes Fernandes, Lucinéia Costa Oliveira, Ana Carolina de Souza Campos, Ágatha Ferreira Xavier de Oliveira, Naiara Vidal Stocco, Cristiane Divan Baldani, Felipe Farias Pereira da Câmara Barros, Cássia Maria Molinaro Coelhohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Vírgínia Conceição TavaresPeixoto, Ana Julia RodriguesFernandes, Maria Eduarda dos Santos LopesOliveira, Lucinéia CostaCampos, Ana Carolina de Souzade Oliveira, Ágatha Ferreira XavierStocco, Naiara VidalBaldani, Cristiane DivanBarros, Felipe Farias Pereira da CâmaraCoelho, Cássia Maria Molinaro2022-09-20T14:25:38Zoai:ojs.rbmv.org:article/1253Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2022-09-20T14:25:38Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false |
dc.title.none.fl_str_mv |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis Comparação de protocolos de fluidoterapia pré-operatória associados a anestesia inalatória ou total intravenosa para procedimentos anestésicos em cães com sepse |
title |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis |
spellingShingle |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis Lima, Vírgínia Conceição Tavares bitches, pyometra, cardiovascular stability, organ dysfunction, arterial hypotension cadelas, piometra, estabilidade cardiovascular, disfunção orgânica, hipotensão arterial. |
title_short |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis |
title_full |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis |
title_fullStr |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis |
title_full_unstemmed |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis |
title_sort |
Comparison of preoperative fluid therapy protocols associated with inhalational or total intravenous anesthesia for anesthetic procedures in dogs with sepsis |
author |
Lima, Vírgínia Conceição Tavares |
author_facet |
Lima, Vírgínia Conceição Tavares Peixoto, Ana Julia Rodrigues Fernandes, Maria Eduarda dos Santos Lopes Oliveira, Lucinéia Costa Campos, Ana Carolina de Souza de Oliveira, Ágatha Ferreira Xavier Stocco, Naiara Vidal Baldani, Cristiane Divan Barros, Felipe Farias Pereira da Câmara Coelho, Cássia Maria Molinaro |
author_role |
author |
author2 |
Peixoto, Ana Julia Rodrigues Fernandes, Maria Eduarda dos Santos Lopes Oliveira, Lucinéia Costa Campos, Ana Carolina de Souza de Oliveira, Ágatha Ferreira Xavier Stocco, Naiara Vidal Baldani, Cristiane Divan Barros, Felipe Farias Pereira da Câmara Coelho, Cássia Maria Molinaro |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Vírgínia Conceição Tavares Peixoto, Ana Julia Rodrigues Fernandes, Maria Eduarda dos Santos Lopes Oliveira, Lucinéia Costa Campos, Ana Carolina de Souza de Oliveira, Ágatha Ferreira Xavier Stocco, Naiara Vidal Baldani, Cristiane Divan Barros, Felipe Farias Pereira da Câmara Coelho, Cássia Maria Molinaro |
dc.subject.por.fl_str_mv |
bitches, pyometra, cardiovascular stability, organ dysfunction, arterial hypotension cadelas, piometra, estabilidade cardiovascular, disfunção orgânica, hipotensão arterial. |
topic |
bitches, pyometra, cardiovascular stability, organ dysfunction, arterial hypotension cadelas, piometra, estabilidade cardiovascular, disfunção orgânica, hipotensão arterial. |
description |
This randomized clinical trial aimed to evaluate different fluid therapy protocols associated with inhalational or total intravenous anesthesia in the cardiorespiratory stability of bitches with sepsis subjected to a surgical procedure to control the infectious focus. Thirty-two bitches diagnosed with pyometra and sepsis and treated at the University Veterinary Hospital between 2018 and 2019 were recruited. After admission, diagnosis, clinical, and laboratory evaluation, patients were randomly distributed into the following groups: propofol 5 (P[5]: preoperative restrictive fluid therapy–5mL/kg/h and intravenous general anesthesia); propofol 10 (P[10]: preoperative liberal fluid therapy–10mL/kg/h and intravenous general anesthesia); and isoflurane 5 (I[5]: preoperative restrictive fluid therapy–5mL/kg/h and inhalational general anesthesia). Lactate on admission (LAC1) and release (LAC2), heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), rectal temperature (RT), oxygen saturation (SpO2 ), and carbon dioxide extraction rate (EtCO2 ) were analyzed at PRE, T10, T20, T30, T40, T50, TEXT, and TDIS. Clearance of 20% of lactate occurred in 18 dogs, with the P[10] group displaying the best performance. There was no statistical difference in vasopressor requirements among the groups. Liberal fluid therapy showed greater cardiovascular stability than restrictive therapy in the perioperative period. Regarding general anesthesia, isoflurane showed greater cardiorespiratory stability than propofol during anesthetic maintenance. In conclusion, although the three proposed protocols are safe and there is no difference in their superiority, some observed changes may be relevant and considered when it is possible to individualize the therapy for the patient. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer reviewed Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbmv.org/BJVM/article/view/1253 10.29374/2527-2179.bjvm001222 |
url |
https://rbmv.org/BJVM/article/view/1253 |
identifier_str_mv |
10.29374/2527-2179.bjvm001222 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbmv.org/BJVM/article/view/1253/1249 https://rbmv.org/BJVM/article/view/1253/1258 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/xml |
dc.publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
publisher.none.fl_str_mv |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro. |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Medicine; Vol. 44 (2022); e001222 Revista Brasileira de Medicina Veterinária; v. 44 (2022); e001222 2527-2179 0100-2430 reponame:Brazilian Journal of Veterinary Medicine instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) instacron:SBMV |
instname_str |
Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
instacron_str |
SBMV |
institution |
SBMV |
reponame_str |
Brazilian Journal of Veterinary Medicine |
collection |
Brazilian Journal of Veterinary Medicine |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ) |
repository.mail.fl_str_mv |
contato.rbmv@gmail.com |
_version_ |
1798313111699062784 |