Depressed cardiac autonomic modulation in patients with chronic kidney disease

Detalhes bibliográficos
Autor(a) principal: Oliveira,Carlos Alberto de
Data de Publicação: 2014
Outros Autores: Brito Junior,Helio Lima de, Bastos,Marcus Gomes, Oliveira,Felipe Gomes de, Casali,Thais Gomes, Bignoto,Tiago Costa, Fernandes,Natalia Maria da Silva, Beraldo,Antonio Fernando de Castro Alves, Paula,Rogério Baumgratz de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155
Resumo: Introduction: A dysfunctional autonomic nervous system (ANS) has also been recognized as an important mechanism contributing to the poor outcome in CKD patients, with several studies reporting a reduction in heart rate variability (HRV). Objective: Evaluate the sympathovagal balance in patients with chronic kidney disease on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance. Results: After tilting, CKD patients had lower sympathetic activity, higher parasympathetic activity, and lower sympathovagal balance than patients in the CON group. Compared to patients in stage 3, patients in stage 5 had a lower LFnu/HFnu ratio, suggesting a more pronounced impairment of sympathovagal balance as the disease progresses. Conclusion: CKD patients not yet on dialysis have reduced HRV, indicating cardiac autonomic dysfunction early in the course of CKD.
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spelling Depressed cardiac autonomic modulation in patients with chronic kidney diseasecardiovascular diseaseskidney diseasesnephrologyrenal insufficiencychronic Introduction: A dysfunctional autonomic nervous system (ANS) has also been recognized as an important mechanism contributing to the poor outcome in CKD patients, with several studies reporting a reduction in heart rate variability (HRV). Objective: Evaluate the sympathovagal balance in patients with chronic kidney disease on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance. Results: After tilting, CKD patients had lower sympathetic activity, higher parasympathetic activity, and lower sympathovagal balance than patients in the CON group. Compared to patients in stage 3, patients in stage 5 had a lower LFnu/HFnu ratio, suggesting a more pronounced impairment of sympathovagal balance as the disease progresses. Conclusion: CKD patients not yet on dialysis have reduced HRV, indicating cardiac autonomic dysfunction early in the course of CKD. Sociedade Brasileira de Nefrologia2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155Brazilian Journal of Nephrology v.36 n.2 2014reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20140025info:eu-repo/semantics/openAccessOliveira,Carlos Alberto deBrito Junior,Helio Lima deBastos,Marcus GomesOliveira,Felipe Gomes deCasali,Thais GomesBignoto,Tiago CostaFernandes,Natalia Maria da SilvaBeraldo,Antonio Fernando de Castro AlvesPaula,Rogério Baumgratz deeng2014-12-10T00:00:00Zoai:scielo:S0101-28002014000200155Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2014-12-10T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Depressed cardiac autonomic modulation in patients with chronic kidney disease
title Depressed cardiac autonomic modulation in patients with chronic kidney disease
spellingShingle Depressed cardiac autonomic modulation in patients with chronic kidney disease
Oliveira,Carlos Alberto de
cardiovascular diseases
kidney diseases
nephrology
renal insufficiency
chronic
title_short Depressed cardiac autonomic modulation in patients with chronic kidney disease
title_full Depressed cardiac autonomic modulation in patients with chronic kidney disease
title_fullStr Depressed cardiac autonomic modulation in patients with chronic kidney disease
title_full_unstemmed Depressed cardiac autonomic modulation in patients with chronic kidney disease
title_sort Depressed cardiac autonomic modulation in patients with chronic kidney disease
author Oliveira,Carlos Alberto de
author_facet Oliveira,Carlos Alberto de
Brito Junior,Helio Lima de
Bastos,Marcus Gomes
Oliveira,Felipe Gomes de
Casali,Thais Gomes
Bignoto,Tiago Costa
Fernandes,Natalia Maria da Silva
Beraldo,Antonio Fernando de Castro Alves
Paula,Rogério Baumgratz de
author_role author
author2 Brito Junior,Helio Lima de
Bastos,Marcus Gomes
Oliveira,Felipe Gomes de
Casali,Thais Gomes
Bignoto,Tiago Costa
Fernandes,Natalia Maria da Silva
Beraldo,Antonio Fernando de Castro Alves
Paula,Rogério Baumgratz de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Carlos Alberto de
Brito Junior,Helio Lima de
Bastos,Marcus Gomes
Oliveira,Felipe Gomes de
Casali,Thais Gomes
Bignoto,Tiago Costa
Fernandes,Natalia Maria da Silva
Beraldo,Antonio Fernando de Castro Alves
Paula,Rogério Baumgratz de
dc.subject.por.fl_str_mv cardiovascular diseases
kidney diseases
nephrology
renal insufficiency
chronic
topic cardiovascular diseases
kidney diseases
nephrology
renal insufficiency
chronic
description Introduction: A dysfunctional autonomic nervous system (ANS) has also been recognized as an important mechanism contributing to the poor outcome in CKD patients, with several studies reporting a reduction in heart rate variability (HRV). Objective: Evaluate the sympathovagal balance in patients with chronic kidney disease on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance. Results: After tilting, CKD patients had lower sympathetic activity, higher parasympathetic activity, and lower sympathovagal balance than patients in the CON group. Compared to patients in stage 3, patients in stage 5 had a lower LFnu/HFnu ratio, suggesting a more pronounced impairment of sympathovagal balance as the disease progresses. Conclusion: CKD patients not yet on dialysis have reduced HRV, indicating cardiac autonomic dysfunction early in the course of CKD.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20140025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.36 n.2 2014
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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