Depressed cardiac autonomic modulation in patients with chronic kidney disease
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155 |
Resumo: | Introduction: A dysfunctional autonomic nervous system (ANS) has also been recognized as an important mechanism contributing to the poor outcome in CKD patients, with several studies reporting a reduction in heart rate variability (HRV). Objective: Evaluate the sympathovagal balance in patients with chronic kidney disease on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance. Results: After tilting, CKD patients had lower sympathetic activity, higher parasympathetic activity, and lower sympathovagal balance than patients in the CON group. Compared to patients in stage 3, patients in stage 5 had a lower LFnu/HFnu ratio, suggesting a more pronounced impairment of sympathovagal balance as the disease progresses. Conclusion: CKD patients not yet on dialysis have reduced HRV, indicating cardiac autonomic dysfunction early in the course of CKD. |
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Depressed cardiac autonomic modulation in patients with chronic kidney diseasecardiovascular diseaseskidney diseasesnephrologyrenal insufficiencychronic Introduction: A dysfunctional autonomic nervous system (ANS) has also been recognized as an important mechanism contributing to the poor outcome in CKD patients, with several studies reporting a reduction in heart rate variability (HRV). Objective: Evaluate the sympathovagal balance in patients with chronic kidney disease on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance. Results: After tilting, CKD patients had lower sympathetic activity, higher parasympathetic activity, and lower sympathovagal balance than patients in the CON group. Compared to patients in stage 3, patients in stage 5 had a lower LFnu/HFnu ratio, suggesting a more pronounced impairment of sympathovagal balance as the disease progresses. Conclusion: CKD patients not yet on dialysis have reduced HRV, indicating cardiac autonomic dysfunction early in the course of CKD. Sociedade Brasileira de Nefrologia2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155Brazilian Journal of Nephrology v.36 n.2 2014reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20140025info:eu-repo/semantics/openAccessOliveira,Carlos Alberto deBrito Junior,Helio Lima deBastos,Marcus GomesOliveira,Felipe Gomes deCasali,Thais GomesBignoto,Tiago CostaFernandes,Natalia Maria da SilvaBeraldo,Antonio Fernando de Castro AlvesPaula,Rogério Baumgratz deeng2014-12-10T00:00:00Zoai:scielo:S0101-28002014000200155Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2014-12-10T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
title |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
spellingShingle |
Depressed cardiac autonomic modulation in patients with chronic kidney disease Oliveira,Carlos Alberto de cardiovascular diseases kidney diseases nephrology renal insufficiency chronic |
title_short |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
title_full |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
title_fullStr |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
title_full_unstemmed |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
title_sort |
Depressed cardiac autonomic modulation in patients with chronic kidney disease |
author |
Oliveira,Carlos Alberto de |
author_facet |
Oliveira,Carlos Alberto de Brito Junior,Helio Lima de Bastos,Marcus Gomes Oliveira,Felipe Gomes de Casali,Thais Gomes Bignoto,Tiago Costa Fernandes,Natalia Maria da Silva Beraldo,Antonio Fernando de Castro Alves Paula,Rogério Baumgratz de |
author_role |
author |
author2 |
Brito Junior,Helio Lima de Bastos,Marcus Gomes Oliveira,Felipe Gomes de Casali,Thais Gomes Bignoto,Tiago Costa Fernandes,Natalia Maria da Silva Beraldo,Antonio Fernando de Castro Alves Paula,Rogério Baumgratz de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Carlos Alberto de Brito Junior,Helio Lima de Bastos,Marcus Gomes Oliveira,Felipe Gomes de Casali,Thais Gomes Bignoto,Tiago Costa Fernandes,Natalia Maria da Silva Beraldo,Antonio Fernando de Castro Alves Paula,Rogério Baumgratz de |
dc.subject.por.fl_str_mv |
cardiovascular diseases kidney diseases nephrology renal insufficiency chronic |
topic |
cardiovascular diseases kidney diseases nephrology renal insufficiency chronic |
description |
Introduction: A dysfunctional autonomic nervous system (ANS) has also been recognized as an important mechanism contributing to the poor outcome in CKD patients, with several studies reporting a reduction in heart rate variability (HRV). Objective: Evaluate the sympathovagal balance in patients with chronic kidney disease on conservative treatment. Methods: In a cross-sectional study, patients with CKD stages 3, 4 and 5 not yet on dialysis (CKD group) and age-matched healthy subjects (CON group) underwent continuous heart rate recording during two twenty-minute periods in the supine position (pre-inclined), followed by passive postural inclination at 70° (inclined period). Power spectral analysis of the heart rate variability was used to assess the normalized low frequency (LFnu), indicative of sympathetic activity, and the normalized high frequency (HFnu), indicative of parasympathetic activity. The LFnu/HFnu ratio represented sympathovagal balance. Results: After tilting, CKD patients had lower sympathetic activity, higher parasympathetic activity, and lower sympathovagal balance than patients in the CON group. Compared to patients in stage 3, patients in stage 5 had a lower LFnu/HFnu ratio, suggesting a more pronounced impairment of sympathovagal balance as the disease progresses. Conclusion: CKD patients not yet on dialysis have reduced HRV, indicating cardiac autonomic dysfunction early in the course of CKD. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000200155 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0101-2800.20140025 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.36 n.2 2014 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
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1752122063396536320 |