Albuminuria and glomerular filtration rate in obese children and adolescents

Detalhes bibliográficos
Autor(a) principal: Sawamura,Luciana Satiko
Data de Publicação: 2019
Outros Autores: Souza,Gabrielle Gomes de, Santos,Juliana Dias Gonçalves dos, Suano-Souza,Fabíola Isabel, Gessullo,Anelise Del Vecchio, Sarni,Roseli Oselka Saccardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000200193
Resumo: Abstract Objective: To describe the frequency of albuminuria in overweight and obese children and adolescents and to relate it to the severity of obesity, pubertal staging, associated morbidities and the glomerular filtration rate. Method: Cross-sectional study including 64 overweight and obese children and adolescents between 5 and 19 years of age. Data collected: weight, height, waist circumference and systemic arterial pressure. Laboratory tests: lipid profile; glycemia and insulin, used to calculate the Homeostasis Model Assessment (HOMA-IR); C-reactive protein; glutamic-pyruvic transaminase and albuminuria in an isolated urine sample (cutoff <30 mg/g). Creatinine was used to calculate the estimated glomerular filtration rate (eGFR, mL/min/1.73 m2). Results: The mean age was 11.6 ± 3.4 years, 32 (50%) and 29 (45.3%) were male and prepubertal. Forty-six (71.9%) had severe obesity. The frequency and median (min/max) of the observed values for albuminuria (> 30 mg/g) were 14 (21.9%) and 9.4 mg/g (0.70, -300.7 mg/g). The mean eGFR was 122.9 ± 24.7 mL/min/1.73 m2. There was no significant correlation between body mass index, pubertal staging, insulin and HOMA-IR with albuminuria values and neither with eGFR. Children with albuminuria tended to have higher values of diastolic blood pressure (75.0 ± 12.2 vs. 68.1 ± 12.4, p = 0.071). Conclusion: Albuminuria, although frequent in children and adolescents with obesity, was not associated with other morbidities and the glomerular filtration rate in these patients.
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spelling Albuminuria and glomerular filtration rate in obese children and adolescentsAlbuminuriaGlomerular Filtration RateObesityChildTeenagerAbstract Objective: To describe the frequency of albuminuria in overweight and obese children and adolescents and to relate it to the severity of obesity, pubertal staging, associated morbidities and the glomerular filtration rate. Method: Cross-sectional study including 64 overweight and obese children and adolescents between 5 and 19 years of age. Data collected: weight, height, waist circumference and systemic arterial pressure. Laboratory tests: lipid profile; glycemia and insulin, used to calculate the Homeostasis Model Assessment (HOMA-IR); C-reactive protein; glutamic-pyruvic transaminase and albuminuria in an isolated urine sample (cutoff <30 mg/g). Creatinine was used to calculate the estimated glomerular filtration rate (eGFR, mL/min/1.73 m2). Results: The mean age was 11.6 ± 3.4 years, 32 (50%) and 29 (45.3%) were male and prepubertal. Forty-six (71.9%) had severe obesity. The frequency and median (min/max) of the observed values for albuminuria (> 30 mg/g) were 14 (21.9%) and 9.4 mg/g (0.70, -300.7 mg/g). The mean eGFR was 122.9 ± 24.7 mL/min/1.73 m2. There was no significant correlation between body mass index, pubertal staging, insulin and HOMA-IR with albuminuria values and neither with eGFR. Children with albuminuria tended to have higher values of diastolic blood pressure (75.0 ± 12.2 vs. 68.1 ± 12.4, p = 0.071). Conclusion: Albuminuria, although frequent in children and adolescents with obesity, was not associated with other morbidities and the glomerular filtration rate in these patients.Sociedade Brasileira de Nefrologia2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000200193Brazilian Journal of Nephrology v.41 n.2 2019reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2018-0006info:eu-repo/semantics/openAccessSawamura,Luciana SatikoSouza,Gabrielle Gomes deSantos,Juliana Dias Gonçalves dosSuano-Souza,Fabíola IsabelGessullo,Anelise Del VecchioSarni,Roseli Oselka Saccardoeng2019-07-29T00:00:00Zoai:scielo:S0101-28002019000200193Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2019-07-29T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Albuminuria and glomerular filtration rate in obese children and adolescents
title Albuminuria and glomerular filtration rate in obese children and adolescents
spellingShingle Albuminuria and glomerular filtration rate in obese children and adolescents
Sawamura,Luciana Satiko
Albuminuria
Glomerular Filtration Rate
Obesity
Child
Teenager
title_short Albuminuria and glomerular filtration rate in obese children and adolescents
title_full Albuminuria and glomerular filtration rate in obese children and adolescents
title_fullStr Albuminuria and glomerular filtration rate in obese children and adolescents
title_full_unstemmed Albuminuria and glomerular filtration rate in obese children and adolescents
title_sort Albuminuria and glomerular filtration rate in obese children and adolescents
author Sawamura,Luciana Satiko
author_facet Sawamura,Luciana Satiko
Souza,Gabrielle Gomes de
Santos,Juliana Dias Gonçalves dos
Suano-Souza,Fabíola Isabel
Gessullo,Anelise Del Vecchio
Sarni,Roseli Oselka Saccardo
author_role author
author2 Souza,Gabrielle Gomes de
Santos,Juliana Dias Gonçalves dos
Suano-Souza,Fabíola Isabel
Gessullo,Anelise Del Vecchio
Sarni,Roseli Oselka Saccardo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sawamura,Luciana Satiko
Souza,Gabrielle Gomes de
Santos,Juliana Dias Gonçalves dos
Suano-Souza,Fabíola Isabel
Gessullo,Anelise Del Vecchio
Sarni,Roseli Oselka Saccardo
dc.subject.por.fl_str_mv Albuminuria
Glomerular Filtration Rate
Obesity
Child
Teenager
topic Albuminuria
Glomerular Filtration Rate
Obesity
Child
Teenager
description Abstract Objective: To describe the frequency of albuminuria in overweight and obese children and adolescents and to relate it to the severity of obesity, pubertal staging, associated morbidities and the glomerular filtration rate. Method: Cross-sectional study including 64 overweight and obese children and adolescents between 5 and 19 years of age. Data collected: weight, height, waist circumference and systemic arterial pressure. Laboratory tests: lipid profile; glycemia and insulin, used to calculate the Homeostasis Model Assessment (HOMA-IR); C-reactive protein; glutamic-pyruvic transaminase and albuminuria in an isolated urine sample (cutoff <30 mg/g). Creatinine was used to calculate the estimated glomerular filtration rate (eGFR, mL/min/1.73 m2). Results: The mean age was 11.6 ± 3.4 years, 32 (50%) and 29 (45.3%) were male and prepubertal. Forty-six (71.9%) had severe obesity. The frequency and median (min/max) of the observed values for albuminuria (> 30 mg/g) were 14 (21.9%) and 9.4 mg/g (0.70, -300.7 mg/g). The mean eGFR was 122.9 ± 24.7 mL/min/1.73 m2. There was no significant correlation between body mass index, pubertal staging, insulin and HOMA-IR with albuminuria values and neither with eGFR. Children with albuminuria tended to have higher values of diastolic blood pressure (75.0 ± 12.2 vs. 68.1 ± 12.4, p = 0.071). Conclusion: Albuminuria, although frequent in children and adolescents with obesity, was not associated with other morbidities and the glomerular filtration rate in these patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000200193
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000200193
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-2018-0006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.41 n.2 2019
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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