90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model

Detalhes bibliográficos
Autor(a) principal: Leite,Cleber A
Data de Publicação: 2017
Outros Autores: Bertoncello,Nádia SC, Watanabe,Ingrid KM, Fernandes,Fernanda B, Andrade,Maria Claudina C, Ronchi,Fernanda A, Arita,Danielle Y, Marcondes,Fernanda K, Cunha,Tatiana S, Casarini,Dulce E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000100011
Resumo: Abstract Introduction: Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
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spelling 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant modelhypertensionkidney transplantationrenin-angiotensin systemAbstract Introduction: Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.Sociedade Brasileira de Nefrologia2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000100011Brazilian Journal of Nephrology v.39 n.1 2017reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20170002info:eu-repo/semantics/openAccessLeite,Cleber ABertoncello,Nádia SCWatanabe,Ingrid KMFernandes,Fernanda BAndrade,Maria Claudina CRonchi,Fernanda AArita,Danielle YMarcondes,Fernanda KCunha,Tatiana SCasarini,Dulce Eeng2017-03-22T00:00:00Zoai:scielo:S0101-28002017000100011Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2017-03-22T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
title 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
spellingShingle 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
Leite,Cleber A
hypertension
kidney transplantation
renin-angiotensin system
title_short 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
title_full 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
title_fullStr 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
title_full_unstemmed 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
title_sort 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model
author Leite,Cleber A
author_facet Leite,Cleber A
Bertoncello,Nádia SC
Watanabe,Ingrid KM
Fernandes,Fernanda B
Andrade,Maria Claudina C
Ronchi,Fernanda A
Arita,Danielle Y
Marcondes,Fernanda K
Cunha,Tatiana S
Casarini,Dulce E
author_role author
author2 Bertoncello,Nádia SC
Watanabe,Ingrid KM
Fernandes,Fernanda B
Andrade,Maria Claudina C
Ronchi,Fernanda A
Arita,Danielle Y
Marcondes,Fernanda K
Cunha,Tatiana S
Casarini,Dulce E
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leite,Cleber A
Bertoncello,Nádia SC
Watanabe,Ingrid KM
Fernandes,Fernanda B
Andrade,Maria Claudina C
Ronchi,Fernanda A
Arita,Danielle Y
Marcondes,Fernanda K
Cunha,Tatiana S
Casarini,Dulce E
dc.subject.por.fl_str_mv hypertension
kidney transplantation
renin-angiotensin system
topic hypertension
kidney transplantation
renin-angiotensin system
description Abstract Introduction: Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000100011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000100011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20170002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.39 n.1 2017
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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