ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400454 |
Resumo: | Abstract The pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. 67% of the glomeruli had fibroepithelial crescents. Moreover, the interstitial space had a moderate lymphomononuclear infiltration and mild fibrosis. In the arterioles, there were walls thickened by subintimal sclerosis. Direct immunofluorescence detected limited IgM and C3 deposits in capillary loops and negative mensangium for IgG, IgA and C1q. A therapy using corticosteroids and intravenous cyclophosphamide was initiated with stable evolution. PICGN associated with SLE is a rare pathology with clinical presentation, varied evolution and without a standard medical treatment. |
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ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosusanti-neutrophil cytoplasmic antibody-associated vasculitisglomerulonephritislupus erythematosus, systemicAbstract The pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. 67% of the glomeruli had fibroepithelial crescents. Moreover, the interstitial space had a moderate lymphomononuclear infiltration and mild fibrosis. In the arterioles, there were walls thickened by subintimal sclerosis. Direct immunofluorescence detected limited IgM and C3 deposits in capillary loops and negative mensangium for IgG, IgA and C1q. A therapy using corticosteroids and intravenous cyclophosphamide was initiated with stable evolution. PICGN associated with SLE is a rare pathology with clinical presentation, varied evolution and without a standard medical treatment.Sociedade Brasileira de Nefrologia2017-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400454Brazilian Journal of Nephrology v.39 n.4 2017reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20170079info:eu-repo/semantics/openAccessHerrera-Añazco,PercyVelásquez-Castillo,PercyPacheco-Mendoza,JosmelValenzuela-Rodriguez,GermánAsato-Higa,Carmeneng2018-01-04T00:00:00Zoai:scielo:S0101-28002017000400454Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-01-04T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
title |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
spellingShingle |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus Herrera-Añazco,Percy anti-neutrophil cytoplasmic antibody-associated vasculitis glomerulonephritis lupus erythematosus, systemic |
title_short |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
title_full |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
title_fullStr |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
title_full_unstemmed |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
title_sort |
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus |
author |
Herrera-Añazco,Percy |
author_facet |
Herrera-Añazco,Percy Velásquez-Castillo,Percy Pacheco-Mendoza,Josmel Valenzuela-Rodriguez,Germán Asato-Higa,Carmen |
author_role |
author |
author2 |
Velásquez-Castillo,Percy Pacheco-Mendoza,Josmel Valenzuela-Rodriguez,Germán Asato-Higa,Carmen |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Herrera-Añazco,Percy Velásquez-Castillo,Percy Pacheco-Mendoza,Josmel Valenzuela-Rodriguez,Germán Asato-Higa,Carmen |
dc.subject.por.fl_str_mv |
anti-neutrophil cytoplasmic antibody-associated vasculitis glomerulonephritis lupus erythematosus, systemic |
topic |
anti-neutrophil cytoplasmic antibody-associated vasculitis glomerulonephritis lupus erythematosus, systemic |
description |
Abstract The pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. 67% of the glomeruli had fibroepithelial crescents. Moreover, the interstitial space had a moderate lymphomononuclear infiltration and mild fibrosis. In the arterioles, there were walls thickened by subintimal sclerosis. Direct immunofluorescence detected limited IgM and C3 deposits in capillary loops and negative mensangium for IgG, IgA and C1q. A therapy using corticosteroids and intravenous cyclophosphamide was initiated with stable evolution. PICGN associated with SLE is a rare pathology with clinical presentation, varied evolution and without a standard medical treatment. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400454 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400454 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0101-2800.20170079 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.39 n.4 2017 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
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1752122064591912960 |