APOL1 risk variants and kidney disease: what we know so far

Detalhes bibliográficos
Autor(a) principal: Siemens,Tobias August
Data de Publicação: 2018
Outros Autores: Riella,Miguel Carlos, Moraes,Thyago Proença de, Riella,Cristian Vidal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000400388
Resumo: ABSTRACT There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carries by protecting against forms of trypanosomiasis, but at the expense of an increased risk of kidney disease. The effect of the variants does not seem to be related to their serum concentration, but rather to local action on the podocytes. Risk variants are also important in renal transplantation, since grafts from donors with risk variants present worse survival.
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spelling APOL1 risk variants and kidney disease: what we know so farGenetics;Apolipoprotein L1KidneyGlomerulosclerosis, Focal SegmentalAIDS-Associated NephropathyNephrosclerosisRenal Insufficiency, ChronicABSTRACT There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carries by protecting against forms of trypanosomiasis, but at the expense of an increased risk of kidney disease. The effect of the variants does not seem to be related to their serum concentration, but rather to local action on the podocytes. Risk variants are also important in renal transplantation, since grafts from donors with risk variants present worse survival.Sociedade Brasileira de Nefrologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000400388Brazilian Journal of Nephrology v.40 n.4 2018reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2017-0033info:eu-repo/semantics/openAccessSiemens,Tobias AugustRiella,Miguel CarlosMoraes,Thyago Proença deRiella,Cristian Vidaleng2019-02-05T00:00:00Zoai:scielo:S0101-28002018000400388Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2019-02-05T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv APOL1 risk variants and kidney disease: what we know so far
title APOL1 risk variants and kidney disease: what we know so far
spellingShingle APOL1 risk variants and kidney disease: what we know so far
Siemens,Tobias August
Genetics;Apolipoprotein L1
Kidney
Glomerulosclerosis, Focal Segmental
AIDS-Associated Nephropathy
Nephrosclerosis
Renal Insufficiency, Chronic
title_short APOL1 risk variants and kidney disease: what we know so far
title_full APOL1 risk variants and kidney disease: what we know so far
title_fullStr APOL1 risk variants and kidney disease: what we know so far
title_full_unstemmed APOL1 risk variants and kidney disease: what we know so far
title_sort APOL1 risk variants and kidney disease: what we know so far
author Siemens,Tobias August
author_facet Siemens,Tobias August
Riella,Miguel Carlos
Moraes,Thyago Proença de
Riella,Cristian Vidal
author_role author
author2 Riella,Miguel Carlos
Moraes,Thyago Proença de
Riella,Cristian Vidal
author2_role author
author
author
dc.contributor.author.fl_str_mv Siemens,Tobias August
Riella,Miguel Carlos
Moraes,Thyago Proença de
Riella,Cristian Vidal
dc.subject.por.fl_str_mv Genetics;Apolipoprotein L1
Kidney
Glomerulosclerosis, Focal Segmental
AIDS-Associated Nephropathy
Nephrosclerosis
Renal Insufficiency, Chronic
topic Genetics;Apolipoprotein L1
Kidney
Glomerulosclerosis, Focal Segmental
AIDS-Associated Nephropathy
Nephrosclerosis
Renal Insufficiency, Chronic
description ABSTRACT There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carries by protecting against forms of trypanosomiasis, but at the expense of an increased risk of kidney disease. The effect of the variants does not seem to be related to their serum concentration, but rather to local action on the podocytes. Risk variants are also important in renal transplantation, since grafts from donors with risk variants present worse survival.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000400388
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000400388
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-2017-0033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.40 n.4 2018
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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