Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000300248 |
Resumo: | ABSTRACT Introduction: Excessive salt intake is a risk factor for the development of chronic kidney disease (CKD). Objective: To evaluate the association between estimated glomerular filtration rate (eGFR) and sodium excretion in urine samples of Brazilians of African ancestry. Methods: Cross-sectional, population-based study of 1,211 Brazilians of African ancestry living in Alcântara City, Maranhão, Brazil. Demographic, nutritional, clinical, and laboratory data were analyzed. The urinary excretion of sodium was estimated using the Kawasaki equation. Calculations of eGFR were based on the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate linear-regression model was used to identify the relationship between sodium excretion and eGFR. Results: Mean age was 37.5±11.7 years and 52.8% were women. Mean urinary excretion of sodium was 204.6±15.3 mmol/day and eGFR was 111.8±15.3 mL/min/1.73m2. According to multivariate linear regression, GFR was independently correlated with sodium excretion (β=0.11; p<0.001), age (β=-0.67; p<0.001), female sex (β=-0.20; p<0.001), and body mass index (BMI; β=-0.09; p<0.001). Conclusions: The present study showed that age, female sex, BMI, and correlated negatively with eGFR. Sodium excretion was the only variable that showed a positive correlation with eGFR, indicating that high levels of urinary sodium excretion may contribute to hyperfiltration with potentially harmful consequences. |
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Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based studySodiumGlomerular Filtration RateChronic Kidney DiseaseVulnerable PopulationABSTRACT Introduction: Excessive salt intake is a risk factor for the development of chronic kidney disease (CKD). Objective: To evaluate the association between estimated glomerular filtration rate (eGFR) and sodium excretion in urine samples of Brazilians of African ancestry. Methods: Cross-sectional, population-based study of 1,211 Brazilians of African ancestry living in Alcântara City, Maranhão, Brazil. Demographic, nutritional, clinical, and laboratory data were analyzed. The urinary excretion of sodium was estimated using the Kawasaki equation. Calculations of eGFR were based on the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate linear-regression model was used to identify the relationship between sodium excretion and eGFR. Results: Mean age was 37.5±11.7 years and 52.8% were women. Mean urinary excretion of sodium was 204.6±15.3 mmol/day and eGFR was 111.8±15.3 mL/min/1.73m2. According to multivariate linear regression, GFR was independently correlated with sodium excretion (β=0.11; p<0.001), age (β=-0.67; p<0.001), female sex (β=-0.20; p<0.001), and body mass index (BMI; β=-0.09; p<0.001). Conclusions: The present study showed that age, female sex, BMI, and correlated negatively with eGFR. Sodium excretion was the only variable that showed a positive correlation with eGFR, indicating that high levels of urinary sodium excretion may contribute to hyperfiltration with potentially harmful consequences.Sociedade Brasileira de Nefrologia2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000300248Brazilian Journal of Nephrology v.40 n.3 2018reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-3864info:eu-repo/semantics/openAccessSantos,Elisângela Milhomem dosBrito,Dyego José de AraújoFrança,Ana Karina da Cunha TeixeiraLages,Joyce SantosSantos,Alcione Miranda dosSalgado Filho,Natalinoeng2018-11-12T00:00:00Zoai:scielo:S0101-28002018000300248Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-11-12T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
title |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
spellingShingle |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study Santos,Elisângela Milhomem dos Sodium Glomerular Filtration Rate Chronic Kidney Disease Vulnerable Population |
title_short |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
title_full |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
title_fullStr |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
title_full_unstemmed |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
title_sort |
Association between estimated glomerular filtration rate and sodium excretion in urine of African descendants in Brazil: a population-based study |
author |
Santos,Elisângela Milhomem dos |
author_facet |
Santos,Elisângela Milhomem dos Brito,Dyego José de Araújo França,Ana Karina da Cunha Teixeira Lages,Joyce Santos Santos,Alcione Miranda dos Salgado Filho,Natalino |
author_role |
author |
author2 |
Brito,Dyego José de Araújo França,Ana Karina da Cunha Teixeira Lages,Joyce Santos Santos,Alcione Miranda dos Salgado Filho,Natalino |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Elisângela Milhomem dos Brito,Dyego José de Araújo França,Ana Karina da Cunha Teixeira Lages,Joyce Santos Santos,Alcione Miranda dos Salgado Filho,Natalino |
dc.subject.por.fl_str_mv |
Sodium Glomerular Filtration Rate Chronic Kidney Disease Vulnerable Population |
topic |
Sodium Glomerular Filtration Rate Chronic Kidney Disease Vulnerable Population |
description |
ABSTRACT Introduction: Excessive salt intake is a risk factor for the development of chronic kidney disease (CKD). Objective: To evaluate the association between estimated glomerular filtration rate (eGFR) and sodium excretion in urine samples of Brazilians of African ancestry. Methods: Cross-sectional, population-based study of 1,211 Brazilians of African ancestry living in Alcântara City, Maranhão, Brazil. Demographic, nutritional, clinical, and laboratory data were analyzed. The urinary excretion of sodium was estimated using the Kawasaki equation. Calculations of eGFR were based on the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate linear-regression model was used to identify the relationship between sodium excretion and eGFR. Results: Mean age was 37.5±11.7 years and 52.8% were women. Mean urinary excretion of sodium was 204.6±15.3 mmol/day and eGFR was 111.8±15.3 mL/min/1.73m2. According to multivariate linear regression, GFR was independently correlated with sodium excretion (β=0.11; p<0.001), age (β=-0.67; p<0.001), female sex (β=-0.20; p<0.001), and body mass index (BMI; β=-0.09; p<0.001). Conclusions: The present study showed that age, female sex, BMI, and correlated negatively with eGFR. Sodium excretion was the only variable that showed a positive correlation with eGFR, indicating that high levels of urinary sodium excretion may contribute to hyperfiltration with potentially harmful consequences. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000300248 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000300248 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-3864 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.40 n.3 2018 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
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1752122064739762176 |