Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review

Detalhes bibliográficos
Autor(a) principal: Balbino,Karla Pereira
Data de Publicação: 2018
Outros Autores: Hermsdorff,Helen Hermana Miranda, Bressan,Josefina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200179
Resumo: ABSTRACT Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular calcification, also able of interfering in the cardiovascular risk of this population. In addition, polymorphisms in genes related to recognized risk factors for CVD, such as dyslipidemia, arterial hypertension and left ventricular hypertrophy, also influence cardiovascular morbidity and mortality.
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spelling Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic reviewChronic Renal FailureInflammationOxidative StressVascular CalcificationHypertrophy, Left VentricularPolymorphism Single NucleotideABSTRACT Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular calcification, also able of interfering in the cardiovascular risk of this population. In addition, polymorphisms in genes related to recognized risk factors for CVD, such as dyslipidemia, arterial hypertension and left ventricular hypertrophy, also influence cardiovascular morbidity and mortality.Sociedade Brasileira de Nefrologia2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200179Brazilian Journal of Nephrology v.40 n.2 2018reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-3857info:eu-repo/semantics/openAccessBalbino,Karla PereiraHermsdorff,Helen Hermana MirandaBressan,Josefinaeng2018-07-24T00:00:00Zoai:scielo:S0101-28002018000200179Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-07-24T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
title Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
spellingShingle Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
Balbino,Karla Pereira
Chronic Renal Failure
Inflammation
Oxidative Stress
Vascular Calcification
Hypertrophy, Left Ventricular
Polymorphism Single Nucleotide
title_short Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
title_full Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
title_fullStr Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
title_full_unstemmed Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
title_sort Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review
author Balbino,Karla Pereira
author_facet Balbino,Karla Pereira
Hermsdorff,Helen Hermana Miranda
Bressan,Josefina
author_role author
author2 Hermsdorff,Helen Hermana Miranda
Bressan,Josefina
author2_role author
author
dc.contributor.author.fl_str_mv Balbino,Karla Pereira
Hermsdorff,Helen Hermana Miranda
Bressan,Josefina
dc.subject.por.fl_str_mv Chronic Renal Failure
Inflammation
Oxidative Stress
Vascular Calcification
Hypertrophy, Left Ventricular
Polymorphism Single Nucleotide
topic Chronic Renal Failure
Inflammation
Oxidative Stress
Vascular Calcification
Hypertrophy, Left Ventricular
Polymorphism Single Nucleotide
description ABSTRACT Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular calcification, also able of interfering in the cardiovascular risk of this population. In addition, polymorphisms in genes related to recognized risk factors for CVD, such as dyslipidemia, arterial hypertension and left ventricular hypertrophy, also influence cardiovascular morbidity and mortality.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200179
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200179
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-3857
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.40 n.2 2018
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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