Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000300289 |
Resumo: | Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy. Objective: evaluate the association between IS levels and biochemical parameters related to mineral metabolism and bone histomorphometry in a cohort of pre-dialysis chronic kidney disease (CKD) patients. Methods: This is a post-hoc analysis of an observational study evaluating the association between coronary calcification and bone biopsy findings in 49 patients (age: 52 ± 10 years; 67% male; estimated glomerular filtration rate: 36 ± 17 ml/min). Serum levels of IS were measured. Results: Patients at CKD stages 2 and 3 presented remarkably low bone formation rate. Patients at CKD stages 4 and 5 presented significantly higher osteoid volume, osteoblast and osteoclast surface, bone fibrosis volume and bone formation rate and a lower mineralization lag time than CKD stage 2 and 3 patients. We observed a positive association between IS levels on one hand and the bone formation rate, osteoid volume, osteoblast surface and bone fibrosis volume on the other. Multivariate regression models confirmed that the associations between IS levels and osteoblast surface and bone fibrosis volume were both independent of demographic and biochemical characteristics of the study population. A similar trend was observed for the bone formation rate. Conclusion: Our findings demonstrated that IS is positively associated with bone formation rate in pre-dialysis CKD patients. |
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Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patientsrenal insufficiency, chronicindoxyl sulfaterenal osteodystrophyuremia Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy. Objective: evaluate the association between IS levels and biochemical parameters related to mineral metabolism and bone histomorphometry in a cohort of pre-dialysis chronic kidney disease (CKD) patients. Methods: This is a post-hoc analysis of an observational study evaluating the association between coronary calcification and bone biopsy findings in 49 patients (age: 52 ± 10 years; 67% male; estimated glomerular filtration rate: 36 ± 17 ml/min). Serum levels of IS were measured. Results: Patients at CKD stages 2 and 3 presented remarkably low bone formation rate. Patients at CKD stages 4 and 5 presented significantly higher osteoid volume, osteoblast and osteoclast surface, bone fibrosis volume and bone formation rate and a lower mineralization lag time than CKD stage 2 and 3 patients. We observed a positive association between IS levels on one hand and the bone formation rate, osteoid volume, osteoblast surface and bone fibrosis volume on the other. Multivariate regression models confirmed that the associations between IS levels and osteoblast surface and bone fibrosis volume were both independent of demographic and biochemical characteristics of the study population. A similar trend was observed for the bone formation rate. Conclusion: Our findings demonstrated that IS is positively associated with bone formation rate in pre-dialysis CKD patients. Sociedade Brasileira de Nefrologia2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000300289Brazilian Journal of Nephrology v.36 n.3 2014reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20140042info:eu-repo/semantics/openAccessBarreto,Fellype CarvalhoBarreto,Daniela VeitCanziani,Maria Eugênia FernandesTomiyama,CristianneHiga,AndreaMozar,AnaïsGlorieux,GrietVanholder,RaymondMassy,ZiadCarvalho,Aluizio Barbosa deeng2014-10-09T00:00:00Zoai:scielo:S0101-28002014000300289Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2014-10-09T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
title |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
spellingShingle |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients Barreto,Fellype Carvalho renal insufficiency, chronic indoxyl sulfate renal osteodystrophy uremia |
title_short |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
title_full |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
title_fullStr |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
title_full_unstemmed |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
title_sort |
Association between indoxyl sulfate and bone histomorphometry in pre-dialysis chronic kidney disease patients |
author |
Barreto,Fellype Carvalho |
author_facet |
Barreto,Fellype Carvalho Barreto,Daniela Veit Canziani,Maria Eugênia Fernandes Tomiyama,Cristianne Higa,Andrea Mozar,Anaïs Glorieux,Griet Vanholder,Raymond Massy,Ziad Carvalho,Aluizio Barbosa de |
author_role |
author |
author2 |
Barreto,Daniela Veit Canziani,Maria Eugênia Fernandes Tomiyama,Cristianne Higa,Andrea Mozar,Anaïs Glorieux,Griet Vanholder,Raymond Massy,Ziad Carvalho,Aluizio Barbosa de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Barreto,Fellype Carvalho Barreto,Daniela Veit Canziani,Maria Eugênia Fernandes Tomiyama,Cristianne Higa,Andrea Mozar,Anaïs Glorieux,Griet Vanholder,Raymond Massy,Ziad Carvalho,Aluizio Barbosa de |
dc.subject.por.fl_str_mv |
renal insufficiency, chronic indoxyl sulfate renal osteodystrophy uremia |
topic |
renal insufficiency, chronic indoxyl sulfate renal osteodystrophy uremia |
description |
Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy. Objective: evaluate the association between IS levels and biochemical parameters related to mineral metabolism and bone histomorphometry in a cohort of pre-dialysis chronic kidney disease (CKD) patients. Methods: This is a post-hoc analysis of an observational study evaluating the association between coronary calcification and bone biopsy findings in 49 patients (age: 52 ± 10 years; 67% male; estimated glomerular filtration rate: 36 ± 17 ml/min). Serum levels of IS were measured. Results: Patients at CKD stages 2 and 3 presented remarkably low bone formation rate. Patients at CKD stages 4 and 5 presented significantly higher osteoid volume, osteoblast and osteoclast surface, bone fibrosis volume and bone formation rate and a lower mineralization lag time than CKD stage 2 and 3 patients. We observed a positive association between IS levels on one hand and the bone formation rate, osteoid volume, osteoblast surface and bone fibrosis volume on the other. Multivariate regression models confirmed that the associations between IS levels and osteoblast surface and bone fibrosis volume were both independent of demographic and biochemical characteristics of the study population. A similar trend was observed for the bone formation rate. Conclusion: Our findings demonstrated that IS is positively associated with bone formation rate in pre-dialysis CKD patients. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000300289 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000300289 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0101-2800.20140042 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.36 n.3 2014 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
_version_ |
1752122063421702144 |