Hepcidin: an important iron metabolism regulator in chronic kidney disease

Detalhes bibliográficos
Autor(a) principal: Antunes,Sandra Azevedo
Data de Publicação: 2016
Outros Autores: Canziani,Maria Eugênia Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002016000300351
Resumo: Abstract Anemia is a common complication and its impact on morbimortality in patients with chronic kidney disease (CKD) is well known. The discovery of hepcidin and its functions has contributed to a better understanding of iron metabolism disorders in CKD anemia. Hepcidin is a peptide mainly produced by hepatocytes and, through a connection with ferroportin, it regulates iron absorption in the duodenum and its release of stock cells. High hepcidin concentrations described in patients with CKD, especially in more advanced stages are attributed to decreased renal excretion and increased production. The elevation of hepcidin has been associated with infection, inflammation, atherosclerosis, insulin resistance and oxidative stress. Some strategies were tested to reduce the effects of hepcidin in patients with CKD, however more studies are necessary to assess the impact of its modulation in the management of anemia in this population.
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spelling Hepcidin: an important iron metabolism regulator in chronic kidney diseaseanemiachronicinflammationpeptidesrenal dialysisrenal insufficiencyAbstract Anemia is a common complication and its impact on morbimortality in patients with chronic kidney disease (CKD) is well known. The discovery of hepcidin and its functions has contributed to a better understanding of iron metabolism disorders in CKD anemia. Hepcidin is a peptide mainly produced by hepatocytes and, through a connection with ferroportin, it regulates iron absorption in the duodenum and its release of stock cells. High hepcidin concentrations described in patients with CKD, especially in more advanced stages are attributed to decreased renal excretion and increased production. The elevation of hepcidin has been associated with infection, inflammation, atherosclerosis, insulin resistance and oxidative stress. Some strategies were tested to reduce the effects of hepcidin in patients with CKD, however more studies are necessary to assess the impact of its modulation in the management of anemia in this population.Sociedade Brasileira de Nefrologia2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002016000300351Brazilian Journal of Nephrology v.38 n.3 2016reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20160053info:eu-repo/semantics/openAccessAntunes,Sandra AzevedoCanziani,Maria Eugênia Fernandeseng2016-10-04T00:00:00Zoai:scielo:S0101-28002016000300351Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2016-10-04T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Hepcidin: an important iron metabolism regulator in chronic kidney disease
title Hepcidin: an important iron metabolism regulator in chronic kidney disease
spellingShingle Hepcidin: an important iron metabolism regulator in chronic kidney disease
Antunes,Sandra Azevedo
anemia
chronic
inflammation
peptides
renal dialysis
renal insufficiency
title_short Hepcidin: an important iron metabolism regulator in chronic kidney disease
title_full Hepcidin: an important iron metabolism regulator in chronic kidney disease
title_fullStr Hepcidin: an important iron metabolism regulator in chronic kidney disease
title_full_unstemmed Hepcidin: an important iron metabolism regulator in chronic kidney disease
title_sort Hepcidin: an important iron metabolism regulator in chronic kidney disease
author Antunes,Sandra Azevedo
author_facet Antunes,Sandra Azevedo
Canziani,Maria Eugênia Fernandes
author_role author
author2 Canziani,Maria Eugênia Fernandes
author2_role author
dc.contributor.author.fl_str_mv Antunes,Sandra Azevedo
Canziani,Maria Eugênia Fernandes
dc.subject.por.fl_str_mv anemia
chronic
inflammation
peptides
renal dialysis
renal insufficiency
topic anemia
chronic
inflammation
peptides
renal dialysis
renal insufficiency
description Abstract Anemia is a common complication and its impact on morbimortality in patients with chronic kidney disease (CKD) is well known. The discovery of hepcidin and its functions has contributed to a better understanding of iron metabolism disorders in CKD anemia. Hepcidin is a peptide mainly produced by hepatocytes and, through a connection with ferroportin, it regulates iron absorption in the duodenum and its release of stock cells. High hepcidin concentrations described in patients with CKD, especially in more advanced stages are attributed to decreased renal excretion and increased production. The elevation of hepcidin has been associated with infection, inflammation, atherosclerosis, insulin resistance and oxidative stress. Some strategies were tested to reduce the effects of hepcidin in patients with CKD, however more studies are necessary to assess the impact of its modulation in the management of anemia in this population.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002016000300351
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002016000300351
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20160053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.38 n.3 2016
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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