Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401 |
Resumo: | Abstract Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance. Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation recipients (KTRs) aged 18- 50 years with primary kidney disease and stable renal graft function. LH, FSH, E2/T, and HOMA-IR were assessed at 1 and 12 months after KT. Results: Twenty-five KTRs were included; 53% were men, and the mean age was 30.6±7.7 years. BMI was 22.3 (20.4-24.6) kg/m2, and 36% had hypogonadism at 1 month vs 8% at 12 months (p=0.001). Re- mission of hypogonadism was observed in all men, while in women, hypogonadotropic hypogonadism persisted in two KTRs at 12 months. A positive correlation between go- nadotrophins and age at 1 and 12 months was evident. Fifty-six percent of patients had insulin resistance (IR) at 1 month and 36% at 12 months (p=0.256). HOMA-IR showed a negative correlation with E2 (r=- 0.60; p=0.050) and T (r=-0.709; p=0.049) at 1 month, with no correlation at 12 months. HOMA-IR at 12 months after KT correlated positively with BMI (r=0.52; p=0.011) and tacrolimus dose (r=0.53; p=0.016). Conclusion: Successful KT restores the HPG axis in the first year. Hypogonadism had a negative correlation with IR in the early pe- riod after KT, but it was not significant at 12 months. |
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Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipientsKidney TransplantationHy- pogonadismEstradiolTestosteroneGo- nadotropinsHyperinsulinismAbstract Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance. Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation recipients (KTRs) aged 18- 50 years with primary kidney disease and stable renal graft function. LH, FSH, E2/T, and HOMA-IR were assessed at 1 and 12 months after KT. Results: Twenty-five KTRs were included; 53% were men, and the mean age was 30.6±7.7 years. BMI was 22.3 (20.4-24.6) kg/m2, and 36% had hypogonadism at 1 month vs 8% at 12 months (p=0.001). Re- mission of hypogonadism was observed in all men, while in women, hypogonadotropic hypogonadism persisted in two KTRs at 12 months. A positive correlation between go- nadotrophins and age at 1 and 12 months was evident. Fifty-six percent of patients had insulin resistance (IR) at 1 month and 36% at 12 months (p=0.256). HOMA-IR showed a negative correlation with E2 (r=- 0.60; p=0.050) and T (r=-0.709; p=0.049) at 1 month, with no correlation at 12 months. HOMA-IR at 12 months after KT correlated positively with BMI (r=0.52; p=0.011) and tacrolimus dose (r=0.53; p=0.016). Conclusion: Successful KT restores the HPG axis in the first year. Hypogonadism had a negative correlation with IR in the early pe- riod after KT, but it was not significant at 12 months.Sociedade Brasileira de Nefrologia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401Brazilian Journal of Nephrology n.ahead 2022reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2021-0250eninfo:eu-repo/semantics/openAccessBalcázar-Hernández,LourdesMendoza-Zubieta,VictoriaGonzález-Virla,BaldomeroGonzález-García,BrendaOsorio-Olvera,MarianaPeñaloza-Juarez,Jesús UbaldoIrisson-Mora,IreneCruz-López,MarthaRodríguez-Gómez,RaúlEspinoza-Pérez,RamónVargas-Ortega,Guadalupeeng2022-05-19T00:00:00Zoai:scielo:S0101-28002022005028401Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2022-05-19T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
title |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
spellingShingle |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients Balcázar-Hernández,Lourdes Kidney Transplantation Hy- pogonadism Estradiol Testosterone Go- nadotropins Hyperinsulinism |
title_short |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
title_full |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
title_fullStr |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
title_full_unstemmed |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
title_sort |
Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients |
author |
Balcázar-Hernández,Lourdes |
author_facet |
Balcázar-Hernández,Lourdes Mendoza-Zubieta,Victoria González-Virla,Baldomero González-García,Brenda Osorio-Olvera,Mariana Peñaloza-Juarez,Jesús Ubaldo Irisson-Mora,Irene Cruz-López,Martha Rodríguez-Gómez,Raúl Espinoza-Pérez,Ramón Vargas-Ortega,Guadalupe |
author_role |
author |
author2 |
Mendoza-Zubieta,Victoria González-Virla,Baldomero González-García,Brenda Osorio-Olvera,Mariana Peñaloza-Juarez,Jesús Ubaldo Irisson-Mora,Irene Cruz-López,Martha Rodríguez-Gómez,Raúl Espinoza-Pérez,Ramón Vargas-Ortega,Guadalupe |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Balcázar-Hernández,Lourdes Mendoza-Zubieta,Victoria González-Virla,Baldomero González-García,Brenda Osorio-Olvera,Mariana Peñaloza-Juarez,Jesús Ubaldo Irisson-Mora,Irene Cruz-López,Martha Rodríguez-Gómez,Raúl Espinoza-Pérez,Ramón Vargas-Ortega,Guadalupe |
dc.subject.por.fl_str_mv |
Kidney Transplantation Hy- pogonadism Estradiol Testosterone Go- nadotropins Hyperinsulinism |
topic |
Kidney Transplantation Hy- pogonadism Estradiol Testosterone Go- nadotropins Hyperinsulinism |
description |
Abstract Objective: To evaluate hypothalamic-pi- tuitary-gonadal (HPG) axis alterations at 1 and 12 months after kidney transplan- tation (KT) and their association with in- sulin resistance. Methods: A retrospective clinical study was conducted in a tertiary care center in kidney transplantation recipients (KTRs) aged 18- 50 years with primary kidney disease and stable renal graft function. LH, FSH, E2/T, and HOMA-IR were assessed at 1 and 12 months after KT. Results: Twenty-five KTRs were included; 53% were men, and the mean age was 30.6±7.7 years. BMI was 22.3 (20.4-24.6) kg/m2, and 36% had hypogonadism at 1 month vs 8% at 12 months (p=0.001). Re- mission of hypogonadism was observed in all men, while in women, hypogonadotropic hypogonadism persisted in two KTRs at 12 months. A positive correlation between go- nadotrophins and age at 1 and 12 months was evident. Fifty-six percent of patients had insulin resistance (IR) at 1 month and 36% at 12 months (p=0.256). HOMA-IR showed a negative correlation with E2 (r=- 0.60; p=0.050) and T (r=-0.709; p=0.049) at 1 month, with no correlation at 12 months. HOMA-IR at 12 months after KT correlated positively with BMI (r=0.52; p=0.011) and tacrolimus dose (r=0.53; p=0.016). Conclusion: Successful KT restores the HPG axis in the first year. Hypogonadism had a negative correlation with IR in the early pe- riod after KT, but it was not significant at 12 months. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005028401 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-2021-0250en |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology n.ahead 2022 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
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1752122067655852032 |