Idiopathic nodular glomerulosclerosis and differential diagnosis

• Autor(a) principal: Solares,Sergio Raúl Alvizures
• Data de Publicação: 2020
• Outros Autores: Ibarra-Sifuentes,Héctor Raúl, Ramírez,María Guadalupe Ramírez, Muller,Giovanna Yazmin Arteaga, Valdez,Jesús Cruz
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Nefrologia
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002020000400484
• topic: Diabetic Nephropathies; Biopsy; Hypertension; Tobacco Use Disorder

ABSTRACT Introduction: Idiopathic nodular glomerulosclerosis (ING) is a condition that has a vasculopathic glomerular histological pattern. Case presentation: The authors present the case of a 44-year-old Hispanic smoker female with hypertension and peripheral arterial disease who presented nephrotic syndrome for 2 weeks. The patient was diagnosed with ING by percutaneous renal biopsy results, which showed global nodular mesangial matrix expansion, with linear staining accentuation of glomerular and tubular basement membrane for Immunoglobulin G (IgG) and albumin on immunofluorescence. Conclusions: ING is a rare disease with a poor renal prognosis and wide diagnostic approach; we highlight the importance of analyzing every piece of detail together to reach a definitive diagnosis.