Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000400534 |
Resumo: | ABSTRACT Introduction: The number of incident and prevalent patients on dialysis has increased, as well as the number of candidates for renal transplantation in Brazil, without a proportional increase in the number of organ donors. The use of expanded kidneys, as to renal function, may be an alternative to increase the supply of organs. Objective: to discuss the feasibility of using expanded kidneys for renal function, which are in severe acute renal injury. Methods: All cases of renal transplantation of deceased donors performed at the Hospital das Clínicas de Botucatu of UNESP, from January 2010 to June 2018, totaling 732 cases were evaluated. Cases with final donor creatinine greater than 6 mg/dL were selected. Results: four patients were selected, of whom all donors were in severe acute kidney injury (AKI). These donors presented rhabdomyolysis as a probable cause of severe AKI, were young, with no comorbidities and had decreased urinary volume in the last 24 hours. The clinical evolution of all the recipients was satisfactory, with a glomerular filtration rate after transplantation ranging from 48 to 98 mL/min/1.73 m2. Conclusion: this series of cases shows the possibility of using renal donors in severe AKI, provided the following are respected: donor age, rhabdomyolysis as the cause of AKI, and implantation-favorable biopsy findings. Additional studies with better designs, larger numbers of patients and longer follow-up times are needed. |
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Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case SeriesKidney TransplantationTissue DonorsDelayed Graft FunctionAcute Kidney InjuryABSTRACT Introduction: The number of incident and prevalent patients on dialysis has increased, as well as the number of candidates for renal transplantation in Brazil, without a proportional increase in the number of organ donors. The use of expanded kidneys, as to renal function, may be an alternative to increase the supply of organs. Objective: to discuss the feasibility of using expanded kidneys for renal function, which are in severe acute renal injury. Methods: All cases of renal transplantation of deceased donors performed at the Hospital das Clínicas de Botucatu of UNESP, from January 2010 to June 2018, totaling 732 cases were evaluated. Cases with final donor creatinine greater than 6 mg/dL were selected. Results: four patients were selected, of whom all donors were in severe acute kidney injury (AKI). These donors presented rhabdomyolysis as a probable cause of severe AKI, were young, with no comorbidities and had decreased urinary volume in the last 24 hours. The clinical evolution of all the recipients was satisfactory, with a glomerular filtration rate after transplantation ranging from 48 to 98 mL/min/1.73 m2. Conclusion: this series of cases shows the possibility of using renal donors in severe AKI, provided the following are respected: donor age, rhabdomyolysis as the cause of AKI, and implantation-favorable biopsy findings. Additional studies with better designs, larger numbers of patients and longer follow-up times are needed.Sociedade Brasileira de Nefrologia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000400534Brazilian Journal of Nephrology v.41 n.4 2019reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2018-0264info:eu-repo/semantics/openAccessSantos,Guilherme Palhares AversaAndrade,Luis Gustavo Modelli deValiatti,Mariana FarinaContti,Mariana MoraesNga,Hong SiTakase,Henrique Mochidaeng2020-01-16T00:00:00Zoai:scielo:S0101-28002019000400534Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2020-01-16T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
title |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
spellingShingle |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series Santos,Guilherme Palhares Aversa Kidney Transplantation Tissue Donors Delayed Graft Function Acute Kidney Injury |
title_short |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
title_full |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
title_fullStr |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
title_full_unstemmed |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
title_sort |
Kidney transplantation with donors in severe acute kidney injury. Should we use these organs? Retrospective Case Series |
author |
Santos,Guilherme Palhares Aversa |
author_facet |
Santos,Guilherme Palhares Aversa Andrade,Luis Gustavo Modelli de Valiatti,Mariana Farina Contti,Mariana Moraes Nga,Hong Si Takase,Henrique Mochida |
author_role |
author |
author2 |
Andrade,Luis Gustavo Modelli de Valiatti,Mariana Farina Contti,Mariana Moraes Nga,Hong Si Takase,Henrique Mochida |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Guilherme Palhares Aversa Andrade,Luis Gustavo Modelli de Valiatti,Mariana Farina Contti,Mariana Moraes Nga,Hong Si Takase,Henrique Mochida |
dc.subject.por.fl_str_mv |
Kidney Transplantation Tissue Donors Delayed Graft Function Acute Kidney Injury |
topic |
Kidney Transplantation Tissue Donors Delayed Graft Function Acute Kidney Injury |
description |
ABSTRACT Introduction: The number of incident and prevalent patients on dialysis has increased, as well as the number of candidates for renal transplantation in Brazil, without a proportional increase in the number of organ donors. The use of expanded kidneys, as to renal function, may be an alternative to increase the supply of organs. Objective: to discuss the feasibility of using expanded kidneys for renal function, which are in severe acute renal injury. Methods: All cases of renal transplantation of deceased donors performed at the Hospital das Clínicas de Botucatu of UNESP, from January 2010 to June 2018, totaling 732 cases were evaluated. Cases with final donor creatinine greater than 6 mg/dL were selected. Results: four patients were selected, of whom all donors were in severe acute kidney injury (AKI). These donors presented rhabdomyolysis as a probable cause of severe AKI, were young, with no comorbidities and had decreased urinary volume in the last 24 hours. The clinical evolution of all the recipients was satisfactory, with a glomerular filtration rate after transplantation ranging from 48 to 98 mL/min/1.73 m2. Conclusion: this series of cases shows the possibility of using renal donors in severe AKI, provided the following are respected: donor age, rhabdomyolysis as the cause of AKI, and implantation-favorable biopsy findings. Additional studies with better designs, larger numbers of patients and longer follow-up times are needed. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000400534 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000400534 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-2018-0264 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.41 n.4 2019 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
_version_ |
1752122065675091968 |