Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye

Detalhes bibliográficos
Autor(a) principal: Ribeiro,Mariana Zaira Moraes Lima
Data de Publicação: 2019
Outros Autores: Lucena,Ana Regina Vieira Peixoto e, Dutra,Barbara de Araujo Lima, Crispim,Joao, Travassos,Simone Benvindo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802019000600389
Resumo: Abstract Purpose: To evaluate visual outcomes of levodopa treatment associated with full occlusion of the dominant eye in patients with refractory amblyopia. Methods: A prospective study of 19 attended patients who were subject to treatment with Levodopa and Carbidopa on doses of 0.7mg/kg/day, a ratio of 4:1 divided into three daily doses for 5 weeks, combined with full occlusion (24 hours/day) of the dominant eye. The ophthalmologic exam from previous consultations up to treatment and after 8 weeks of therapy were collected from medical record data. Patients who had completed treatment for more than 12 months were included for complete eye examination. Results: The mean age before treatment with levodopa was 11.0 ± 4.2 years old (varying from 7 to 23 years). The best-corrected visual acuity (Snellen chart) of the amblyopic eye before treatment was 0.24 (0.6 in logMAR) ± 0.16, after 8 weeks of treatment it was 0.47(0.3 in logMAR) ± 0.33, while during the final evaluation it was 0.46 (0.3 in logMAR) ± 0.34. There was a statistically significant improvement in vision after 8 weeks of therapy which was maintained until the final evaluation (p = 0.007). Conclusion: Levodopa/Carbidopa therapyat doses of 0.7 mg/kg/day at a ratio of 4:1 divided in three daily doses, associated with full occlusion of the dominant eye during 5 weeks had a significant improvement on the visual acuity of the amblyopic eye, and persisted up to 1 year after the treatment.
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spelling Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eyeAmblyopiaLevodopa/administration & dosageDrug combinationsAbstract Purpose: To evaluate visual outcomes of levodopa treatment associated with full occlusion of the dominant eye in patients with refractory amblyopia. Methods: A prospective study of 19 attended patients who were subject to treatment with Levodopa and Carbidopa on doses of 0.7mg/kg/day, a ratio of 4:1 divided into three daily doses for 5 weeks, combined with full occlusion (24 hours/day) of the dominant eye. The ophthalmologic exam from previous consultations up to treatment and after 8 weeks of therapy were collected from medical record data. Patients who had completed treatment for more than 12 months were included for complete eye examination. Results: The mean age before treatment with levodopa was 11.0 ± 4.2 years old (varying from 7 to 23 years). The best-corrected visual acuity (Snellen chart) of the amblyopic eye before treatment was 0.24 (0.6 in logMAR) ± 0.16, after 8 weeks of treatment it was 0.47(0.3 in logMAR) ± 0.33, while during the final evaluation it was 0.46 (0.3 in logMAR) ± 0.34. There was a statistically significant improvement in vision after 8 weeks of therapy which was maintained until the final evaluation (p = 0.007). Conclusion: Levodopa/Carbidopa therapyat doses of 0.7 mg/kg/day at a ratio of 4:1 divided in three daily doses, associated with full occlusion of the dominant eye during 5 weeks had a significant improvement on the visual acuity of the amblyopic eye, and persisted up to 1 year after the treatment.Sociedade Brasileira de Oftalmologia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802019000600389Revista Brasileira de Oftalmologia v.78 n.6 2019reponame:Revista Brasileira de Oftalmologia (Online)instname:Sociedade Brasileira de Oftalmologia (SBO)instacron:SBO10.5935/0034-7280.20190167info:eu-repo/semantics/openAccessRibeiro,Mariana Zaira Moraes LimaLucena,Ana Regina Vieira Peixoto eDutra,Barbara de Araujo LimaCrispim,JoaoTravassos,Simone Benvindoeng2019-11-27T00:00:00Zoai:scielo:S0034-72802019000600389Revistahttps://rbo.emnuvens.com.br/rbo/indexhttps://old.scielo.br/oai/scielo-oai.phpsob@sboportal.org.br||rbo@sboportal.org.br1982-85510034-7280opendoar:2019-11-27T00:00Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)false
dc.title.none.fl_str_mv Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
title Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
spellingShingle Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
Ribeiro,Mariana Zaira Moraes Lima
Amblyopia
Levodopa/administration & dosage
Drug combinations
title_short Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
title_full Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
title_fullStr Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
title_full_unstemmed Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
title_sort Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
author Ribeiro,Mariana Zaira Moraes Lima
author_facet Ribeiro,Mariana Zaira Moraes Lima
Lucena,Ana Regina Vieira Peixoto e
Dutra,Barbara de Araujo Lima
Crispim,Joao
Travassos,Simone Benvindo
author_role author
author2 Lucena,Ana Regina Vieira Peixoto e
Dutra,Barbara de Araujo Lima
Crispim,Joao
Travassos,Simone Benvindo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro,Mariana Zaira Moraes Lima
Lucena,Ana Regina Vieira Peixoto e
Dutra,Barbara de Araujo Lima
Crispim,Joao
Travassos,Simone Benvindo
dc.subject.por.fl_str_mv Amblyopia
Levodopa/administration & dosage
Drug combinations
topic Amblyopia
Levodopa/administration & dosage
Drug combinations
description Abstract Purpose: To evaluate visual outcomes of levodopa treatment associated with full occlusion of the dominant eye in patients with refractory amblyopia. Methods: A prospective study of 19 attended patients who were subject to treatment with Levodopa and Carbidopa on doses of 0.7mg/kg/day, a ratio of 4:1 divided into three daily doses for 5 weeks, combined with full occlusion (24 hours/day) of the dominant eye. The ophthalmologic exam from previous consultations up to treatment and after 8 weeks of therapy were collected from medical record data. Patients who had completed treatment for more than 12 months were included for complete eye examination. Results: The mean age before treatment with levodopa was 11.0 ± 4.2 years old (varying from 7 to 23 years). The best-corrected visual acuity (Snellen chart) of the amblyopic eye before treatment was 0.24 (0.6 in logMAR) ± 0.16, after 8 weeks of treatment it was 0.47(0.3 in logMAR) ± 0.33, while during the final evaluation it was 0.46 (0.3 in logMAR) ± 0.34. There was a statistically significant improvement in vision after 8 weeks of therapy which was maintained until the final evaluation (p = 0.007). Conclusion: Levodopa/Carbidopa therapyat doses of 0.7 mg/kg/day at a ratio of 4:1 divided in three daily doses, associated with full occlusion of the dominant eye during 5 weeks had a significant improvement on the visual acuity of the amblyopic eye, and persisted up to 1 year after the treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802019000600389
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0034-7280.20190167
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
dc.source.none.fl_str_mv Revista Brasileira de Oftalmologia v.78 n.6 2019
reponame:Revista Brasileira de Oftalmologia (Online)
instname:Sociedade Brasileira de Oftalmologia (SBO)
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reponame_str Revista Brasileira de Oftalmologia (Online)
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repository.name.fl_str_mv Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)
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