Bilateral ocular deposit of chlorpromazine

Detalhes bibliográficos
Autor(a) principal: Flügel,Nayara Teixeira
Data de Publicação: 2022
Outros Autores: Valle,Giulia Steuernagel Del, Wasilewski,Daniel
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista Brasileira de Oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802022000100517
Resumo: ABSTRACT Chlorpromazine is a medication widely used in psychiatry for the treatment of psychoses, especially schizophrenia. Since 1964, published articles have been correlating this medication with the appearance of ocular alterations. In this paper, we report the case of a 65-year-old patient with ocular effects due to long-term therapy with chlorpromazine. Biomicroscopy of both eyes presented diffuse granular brown deposits, most prominent at the deep stroma and corneal endothelium level. Also showed anterior subcapsular brown deposits with a stellate pattern in the lens. The total amount exceeds 2.000g (significant for the ocular alterations described) considering the patient's daily dosage of chlorpromazine of 300mg for ten years. After performing complete ophthalmic evaluation and discarding other causes for the ocular deposits, we diagnosed a secondary corneal deposit and cataract due to the use of chlorpromazine. This case reinforces the importance of periodic follow-up with an ophthalmologist for chlorpromazine users to trace ocular changes, heeding the exposure time and its dosage.
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spelling Bilateral ocular deposit of chlorpromazineCorneaLens, crystallineLens diseasesCataractChlorpromazineAntipsychotics agentsABSTRACT Chlorpromazine is a medication widely used in psychiatry for the treatment of psychoses, especially schizophrenia. Since 1964, published articles have been correlating this medication with the appearance of ocular alterations. In this paper, we report the case of a 65-year-old patient with ocular effects due to long-term therapy with chlorpromazine. Biomicroscopy of both eyes presented diffuse granular brown deposits, most prominent at the deep stroma and corneal endothelium level. Also showed anterior subcapsular brown deposits with a stellate pattern in the lens. The total amount exceeds 2.000g (significant for the ocular alterations described) considering the patient's daily dosage of chlorpromazine of 300mg for ten years. After performing complete ophthalmic evaluation and discarding other causes for the ocular deposits, we diagnosed a secondary corneal deposit and cataract due to the use of chlorpromazine. This case reinforces the importance of periodic follow-up with an ophthalmologist for chlorpromazine users to trace ocular changes, heeding the exposure time and its dosage.Sociedade Brasileira de Oftalmologia2022-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802022000100517Revista Brasileira de Oftalmologia v.81 2022reponame:Revista Brasileira de Oftalmologia (Online)instname:Sociedade Brasileira de Oftalmologia (SBO)instacron:SBO10.37039/1982.8551.20220070info:eu-repo/semantics/openAccessFlügel,Nayara TeixeiraValle,Giulia Steuernagel DelWasilewski,Danieleng2022-11-28T00:00:00Zoai:scielo:S0034-72802022000100517Revistahttps://rbo.emnuvens.com.br/rbo/indexhttps://old.scielo.br/oai/scielo-oai.phpsob@sboportal.org.br||rbo@sboportal.org.br1982-85510034-7280opendoar:2022-11-28T00:00Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)false
dc.title.none.fl_str_mv Bilateral ocular deposit of chlorpromazine
title Bilateral ocular deposit of chlorpromazine
spellingShingle Bilateral ocular deposit of chlorpromazine
Flügel,Nayara Teixeira
Cornea
Lens, crystalline
Lens diseases
Cataract
Chlorpromazine
Antipsychotics agents
title_short Bilateral ocular deposit of chlorpromazine
title_full Bilateral ocular deposit of chlorpromazine
title_fullStr Bilateral ocular deposit of chlorpromazine
title_full_unstemmed Bilateral ocular deposit of chlorpromazine
title_sort Bilateral ocular deposit of chlorpromazine
author Flügel,Nayara Teixeira
author_facet Flügel,Nayara Teixeira
Valle,Giulia Steuernagel Del
Wasilewski,Daniel
author_role author
author2 Valle,Giulia Steuernagel Del
Wasilewski,Daniel
author2_role author
author
dc.contributor.author.fl_str_mv Flügel,Nayara Teixeira
Valle,Giulia Steuernagel Del
Wasilewski,Daniel
dc.subject.por.fl_str_mv Cornea
Lens, crystalline
Lens diseases
Cataract
Chlorpromazine
Antipsychotics agents
topic Cornea
Lens, crystalline
Lens diseases
Cataract
Chlorpromazine
Antipsychotics agents
description ABSTRACT Chlorpromazine is a medication widely used in psychiatry for the treatment of psychoses, especially schizophrenia. Since 1964, published articles have been correlating this medication with the appearance of ocular alterations. In this paper, we report the case of a 65-year-old patient with ocular effects due to long-term therapy with chlorpromazine. Biomicroscopy of both eyes presented diffuse granular brown deposits, most prominent at the deep stroma and corneal endothelium level. Also showed anterior subcapsular brown deposits with a stellate pattern in the lens. The total amount exceeds 2.000g (significant for the ocular alterations described) considering the patient's daily dosage of chlorpromazine of 300mg for ten years. After performing complete ophthalmic evaluation and discarding other causes for the ocular deposits, we diagnosed a secondary corneal deposit and cataract due to the use of chlorpromazine. This case reinforces the importance of periodic follow-up with an ophthalmologist for chlorpromazine users to trace ocular changes, heeding the exposure time and its dosage.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802022000100517
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.37039/1982.8551.20220070
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
dc.source.none.fl_str_mv Revista Brasileira de Oftalmologia v.81 2022
reponame:Revista Brasileira de Oftalmologia (Online)
instname:Sociedade Brasileira de Oftalmologia (SBO)
instacron:SBO
instname_str Sociedade Brasileira de Oftalmologia (SBO)
instacron_str SBO
institution SBO
reponame_str Revista Brasileira de Oftalmologia (Online)
collection Revista Brasileira de Oftalmologia (Online)
repository.name.fl_str_mv Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)
repository.mail.fl_str_mv sob@sboportal.org.br||rbo@sboportal.org.br
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