Importance of genetic polymorphisms in the response to age-related macular degeneration treatment

Detalhes bibliográficos
Autor(a) principal: Veloso,Carlos Eduardo dos Reis
Data de Publicação: 2012
Outros Autores: Almeida,Luciana Negrão Frota de, De Marco,Luiz Armando, Vianna,Raul Nunes Galvarro, Nehemy,Márcio Bittar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802012000300011
Resumo: Age-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch's membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we review the literature to analyze the association between the main genetic polymorphisms and the response to the existing therapeutic modalities. Patients with CFH high-risk alleles show a poorer response to preventive treatment of AMD with antioxidants and zinc.The association between genetic polymorphisms and response to photodynamic therapy and antiangiogenic drugs, however, is controversial until now.
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spelling Importance of genetic polymorphisms in the response to age-related macular degeneration treatmentMacular degeneration/geneticsAntioxidantsPolymorphism/geneticTreatment outcomeAge-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch's membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we review the literature to analyze the association between the main genetic polymorphisms and the response to the existing therapeutic modalities. Patients with CFH high-risk alleles show a poorer response to preventive treatment of AMD with antioxidants and zinc.The association between genetic polymorphisms and response to photodynamic therapy and antiangiogenic drugs, however, is controversial until now.Sociedade Brasileira de Oftalmologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802012000300011Revista Brasileira de Oftalmologia v.71 n.3 2012reponame:Revista Brasileira de Oftalmologia (Online)instname:Sociedade Brasileira de Oftalmologia (SBO)instacron:SBO10.1590/S0034-72802012000300011info:eu-repo/semantics/openAccessVeloso,Carlos Eduardo dos ReisAlmeida,Luciana Negrão Frota deDe Marco,Luiz ArmandoVianna,Raul Nunes GalvarroNehemy,Márcio Bittareng2012-07-31T00:00:00Zoai:scielo:S0034-72802012000300011Revistahttps://rbo.emnuvens.com.br/rbo/indexhttps://old.scielo.br/oai/scielo-oai.phpsob@sboportal.org.br||rbo@sboportal.org.br1982-85510034-7280opendoar:2012-07-31T00:00Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)false
dc.title.none.fl_str_mv Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
title Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
spellingShingle Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
Veloso,Carlos Eduardo dos Reis
Macular degeneration/genetics
Antioxidants
Polymorphism/genetic
Treatment outcome
title_short Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
title_full Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
title_fullStr Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
title_full_unstemmed Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
title_sort Importance of genetic polymorphisms in the response to age-related macular degeneration treatment
author Veloso,Carlos Eduardo dos Reis
author_facet Veloso,Carlos Eduardo dos Reis
Almeida,Luciana Negrão Frota de
De Marco,Luiz Armando
Vianna,Raul Nunes Galvarro
Nehemy,Márcio Bittar
author_role author
author2 Almeida,Luciana Negrão Frota de
De Marco,Luiz Armando
Vianna,Raul Nunes Galvarro
Nehemy,Márcio Bittar
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Veloso,Carlos Eduardo dos Reis
Almeida,Luciana Negrão Frota de
De Marco,Luiz Armando
Vianna,Raul Nunes Galvarro
Nehemy,Márcio Bittar
dc.subject.por.fl_str_mv Macular degeneration/genetics
Antioxidants
Polymorphism/genetic
Treatment outcome
topic Macular degeneration/genetics
Antioxidants
Polymorphism/genetic
Treatment outcome
description Age-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch's membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we review the literature to analyze the association between the main genetic polymorphisms and the response to the existing therapeutic modalities. Patients with CFH high-risk alleles show a poorer response to preventive treatment of AMD with antioxidants and zinc.The association between genetic polymorphisms and response to photodynamic therapy and antiangiogenic drugs, however, is controversial until now.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802012000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802012000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0034-72802012000300011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
dc.source.none.fl_str_mv Revista Brasileira de Oftalmologia v.71 n.3 2012
reponame:Revista Brasileira de Oftalmologia (Online)
instname:Sociedade Brasileira de Oftalmologia (SBO)
instacron:SBO
instname_str Sociedade Brasileira de Oftalmologia (SBO)
instacron_str SBO
institution SBO
reponame_str Revista Brasileira de Oftalmologia (Online)
collection Revista Brasileira de Oftalmologia (Online)
repository.name.fl_str_mv Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)
repository.mail.fl_str_mv sob@sboportal.org.br||rbo@sboportal.org.br
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