Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review

Detalhes bibliográficos
Autor(a) principal: Kasahara,Niro
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802015000400257
Resumo: ABSTRACT Glaucoma is a group of progressive optic neuropathies that have in common a slow progressive degeneration of retinal ganglion cells and their axons, resulting in a distinct appearance of the optic disc and a concomitant pattern of visual loss. Biomarkers are characteristics objectively measured and evaluated as indication of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Several biological markers have been implicated with glaucoma, especially genetics, proteomics, autoimmune and other molecular biomarkers, although, most awaits clinical validation. There are clear potential benefits in using biomarkers. Information can be obtained earlier, faster, and less costly. This review summarizes the latest developments and approaches in glaucoma biomarkers and its possible uses in the diagnosis, staging, and as predictors of response to treatment.
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spelling Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a reviewGlaucomaOptic nerve diseasesBiological makersGlaucomaDoenças do nervo ópticoMarcadores biológicosABSTRACT Glaucoma is a group of progressive optic neuropathies that have in common a slow progressive degeneration of retinal ganglion cells and their axons, resulting in a distinct appearance of the optic disc and a concomitant pattern of visual loss. Biomarkers are characteristics objectively measured and evaluated as indication of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Several biological markers have been implicated with glaucoma, especially genetics, proteomics, autoimmune and other molecular biomarkers, although, most awaits clinical validation. There are clear potential benefits in using biomarkers. Information can be obtained earlier, faster, and less costly. This review summarizes the latest developments and approaches in glaucoma biomarkers and its possible uses in the diagnosis, staging, and as predictors of response to treatment.Sociedade Brasileira de Oftalmologia2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802015000400257Revista Brasileira de Oftalmologia v.74 n.4 2015reponame:Revista Brasileira de Oftalmologia (Online)instname:Sociedade Brasileira de Oftalmologia (SBO)instacron:SBO10.5935/0034-7280.20150054info:eu-repo/semantics/openAccessKasahara,Niroeng2015-11-26T00:00:00Zoai:scielo:S0034-72802015000400257Revistahttps://rbo.emnuvens.com.br/rbo/indexhttps://old.scielo.br/oai/scielo-oai.phpsob@sboportal.org.br||rbo@sboportal.org.br1982-85510034-7280opendoar:2015-11-26T00:00Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)false
dc.title.none.fl_str_mv Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
title Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
spellingShingle Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
Kasahara,Niro
Glaucoma
Optic nerve diseases
Biological makers
Glaucoma
Doenças do nervo óptico
Marcadores biológicos
title_short Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
title_full Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
title_fullStr Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
title_full_unstemmed Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
title_sort Biomarkers and surrogate endpoints in the glaucomatous optic neuropathy: new developments and a review
author Kasahara,Niro
author_facet Kasahara,Niro
author_role author
dc.contributor.author.fl_str_mv Kasahara,Niro
dc.subject.por.fl_str_mv Glaucoma
Optic nerve diseases
Biological makers
Glaucoma
Doenças do nervo óptico
Marcadores biológicos
topic Glaucoma
Optic nerve diseases
Biological makers
Glaucoma
Doenças do nervo óptico
Marcadores biológicos
description ABSTRACT Glaucoma is a group of progressive optic neuropathies that have in common a slow progressive degeneration of retinal ganglion cells and their axons, resulting in a distinct appearance of the optic disc and a concomitant pattern of visual loss. Biomarkers are characteristics objectively measured and evaluated as indication of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Several biological markers have been implicated with glaucoma, especially genetics, proteomics, autoimmune and other molecular biomarkers, although, most awaits clinical validation. There are clear potential benefits in using biomarkers. Information can be obtained earlier, faster, and less costly. This review summarizes the latest developments and approaches in glaucoma biomarkers and its possible uses in the diagnosis, staging, and as predictors of response to treatment.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802015000400257
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0034-7280.20150054
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
dc.source.none.fl_str_mv Revista Brasileira de Oftalmologia v.74 n.4 2015
reponame:Revista Brasileira de Oftalmologia (Online)
instname:Sociedade Brasileira de Oftalmologia (SBO)
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repository.name.fl_str_mv Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)
repository.mail.fl_str_mv sob@sboportal.org.br||rbo@sboportal.org.br
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