Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome

Detalhes bibliográficos
Autor(a) principal: Guliyev,Derya Alp
Data de Publicação: 2016
Outros Autores: Cabuk,Kubra Serefoglu, Kirgiz,Ahmet, Usta,Abdullah Taner, Kovalak,Evrim Ebru, Guliyev,Vusal, Taskapili,Muhittin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802016000500380
Resumo: ABSTRACT Purpose: Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by chronic anovulation and hyperandrogenism. Hormonal changes can affect tear function. This study evaluates tear function and impact of hyperandrogenism on it in PCOS patients. Methods: Fifty patients with PCOS and thirty control volunteers were examined for tear break-up time, Schirmer-I and tear osmolarity. Also, serum levels of total testosterone, FSH, LH and AMH were determined in venous blood samples in the early follicular phase. PCOS patients were divided into two groups by plasma total testosterone level: Group A with normal (≤0.513 ng/ml;n=27), Group B with higher hormone level (>0.513 ng/ml;n=23). Healthy control group indicated as Group C (n=30). Results: LH, total testosterone levels were higher in the PCOS group than in the control group (p=0.012; p=0.025). Mean values of tear break-up time and Schirmer-I were different between groups and especially Group A and C were near to each other differing from B (p>0.05). Tear osmolarity results were higher in Group B, compared to A and C (p=0.049; p=0.033). No significant difference detected in tear osmolarity value means of Group A and C (p=0.107). AMH levels were higher in Group B, compared to A and C (p=0.002; p=0.001). AMH levels in Group A were higher than that of C (p=0.002). Positive correlation between levels of total testosterone and AMH was detected in all PCOS patients (n=50;Pearson's r=0.579; p<0.001). Conclusion: Tear function can be affected in PCOS patients with hyperandrogenism. Tear osmolarity is the most sensitive and objective assessment method for ocular surface changes in PCOS.
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spelling Tear osmolarity and tear function assessment in patients with polycystic ovary syndromePolycystic ovary syndromeTears/physiologyOsmolar concentrationHyperandrogenismAnti-müllerian hormoneABSTRACT Purpose: Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by chronic anovulation and hyperandrogenism. Hormonal changes can affect tear function. This study evaluates tear function and impact of hyperandrogenism on it in PCOS patients. Methods: Fifty patients with PCOS and thirty control volunteers were examined for tear break-up time, Schirmer-I and tear osmolarity. Also, serum levels of total testosterone, FSH, LH and AMH were determined in venous blood samples in the early follicular phase. PCOS patients were divided into two groups by plasma total testosterone level: Group A with normal (≤0.513 ng/ml;n=27), Group B with higher hormone level (>0.513 ng/ml;n=23). Healthy control group indicated as Group C (n=30). Results: LH, total testosterone levels were higher in the PCOS group than in the control group (p=0.012; p=0.025). Mean values of tear break-up time and Schirmer-I were different between groups and especially Group A and C were near to each other differing from B (p>0.05). Tear osmolarity results were higher in Group B, compared to A and C (p=0.049; p=0.033). No significant difference detected in tear osmolarity value means of Group A and C (p=0.107). AMH levels were higher in Group B, compared to A and C (p=0.002; p=0.001). AMH levels in Group A were higher than that of C (p=0.002). Positive correlation between levels of total testosterone and AMH was detected in all PCOS patients (n=50;Pearson's r=0.579; p<0.001). Conclusion: Tear function can be affected in PCOS patients with hyperandrogenism. Tear osmolarity is the most sensitive and objective assessment method for ocular surface changes in PCOS.Sociedade Brasileira de Oftalmologia2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802016000500380Revista Brasileira de Oftalmologia v.75 n.5 2016reponame:Revista Brasileira de Oftalmologia (Online)instname:Sociedade Brasileira de Oftalmologia (SBO)instacron:SBO10.5935/0034-7280.20160076info:eu-repo/semantics/openAccessGuliyev,Derya AlpCabuk,Kubra SerefogluKirgiz,AhmetUsta,Abdullah TanerKovalak,Evrim EbruGuliyev,VusalTaskapili,Muhittineng2016-10-31T00:00:00Zoai:scielo:S0034-72802016000500380Revistahttps://rbo.emnuvens.com.br/rbo/indexhttps://old.scielo.br/oai/scielo-oai.phpsob@sboportal.org.br||rbo@sboportal.org.br1982-85510034-7280opendoar:2016-10-31T00:00Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)false
dc.title.none.fl_str_mv Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
title Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
spellingShingle Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
Guliyev,Derya Alp
Polycystic ovary syndrome
Tears/physiology
Osmolar concentration
Hyperandrogenism
Anti-müllerian hormone
title_short Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
title_full Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
title_fullStr Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
title_full_unstemmed Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
title_sort Tear osmolarity and tear function assessment in patients with polycystic ovary syndrome
author Guliyev,Derya Alp
author_facet Guliyev,Derya Alp
Cabuk,Kubra Serefoglu
Kirgiz,Ahmet
Usta,Abdullah Taner
Kovalak,Evrim Ebru
Guliyev,Vusal
Taskapili,Muhittin
author_role author
author2 Cabuk,Kubra Serefoglu
Kirgiz,Ahmet
Usta,Abdullah Taner
Kovalak,Evrim Ebru
Guliyev,Vusal
Taskapili,Muhittin
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guliyev,Derya Alp
Cabuk,Kubra Serefoglu
Kirgiz,Ahmet
Usta,Abdullah Taner
Kovalak,Evrim Ebru
Guliyev,Vusal
Taskapili,Muhittin
dc.subject.por.fl_str_mv Polycystic ovary syndrome
Tears/physiology
Osmolar concentration
Hyperandrogenism
Anti-müllerian hormone
topic Polycystic ovary syndrome
Tears/physiology
Osmolar concentration
Hyperandrogenism
Anti-müllerian hormone
description ABSTRACT Purpose: Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by chronic anovulation and hyperandrogenism. Hormonal changes can affect tear function. This study evaluates tear function and impact of hyperandrogenism on it in PCOS patients. Methods: Fifty patients with PCOS and thirty control volunteers were examined for tear break-up time, Schirmer-I and tear osmolarity. Also, serum levels of total testosterone, FSH, LH and AMH were determined in venous blood samples in the early follicular phase. PCOS patients were divided into two groups by plasma total testosterone level: Group A with normal (≤0.513 ng/ml;n=27), Group B with higher hormone level (>0.513 ng/ml;n=23). Healthy control group indicated as Group C (n=30). Results: LH, total testosterone levels were higher in the PCOS group than in the control group (p=0.012; p=0.025). Mean values of tear break-up time and Schirmer-I were different between groups and especially Group A and C were near to each other differing from B (p>0.05). Tear osmolarity results were higher in Group B, compared to A and C (p=0.049; p=0.033). No significant difference detected in tear osmolarity value means of Group A and C (p=0.107). AMH levels were higher in Group B, compared to A and C (p=0.002; p=0.001). AMH levels in Group A were higher than that of C (p=0.002). Positive correlation between levels of total testosterone and AMH was detected in all PCOS patients (n=50;Pearson's r=0.579; p<0.001). Conclusion: Tear function can be affected in PCOS patients with hyperandrogenism. Tear osmolarity is the most sensitive and objective assessment method for ocular surface changes in PCOS.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802016000500380
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802016000500380
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0034-7280.20160076
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
publisher.none.fl_str_mv Sociedade Brasileira de Oftalmologia
dc.source.none.fl_str_mv Revista Brasileira de Oftalmologia v.75 n.5 2016
reponame:Revista Brasileira de Oftalmologia (Online)
instname:Sociedade Brasileira de Oftalmologia (SBO)
instacron:SBO
instname_str Sociedade Brasileira de Oftalmologia (SBO)
instacron_str SBO
institution SBO
reponame_str Revista Brasileira de Oftalmologia (Online)
collection Revista Brasileira de Oftalmologia (Online)
repository.name.fl_str_mv Revista Brasileira de Oftalmologia (Online) - Sociedade Brasileira de Oftalmologia (SBO)
repository.mail.fl_str_mv sob@sboportal.org.br||rbo@sboportal.org.br
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