Evaluation of simvastatin in the process of fracture healing in tibiae of rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Ortopedia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191 |
Resumo: | OBJECTIVE: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia. METHODS: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice. In the control group was administered saline by the same route of SG. Immobilization was not used. After the sacrifice was made to limb amputation in the distal femur and conducted the clinical, radiological and histological analysis. Clinical evaluation was made as to the mobility of the fracture. Then the samples were radiographed and evaluated for callus diameter. Histological examination was performed with cuts of 5 micrometers and stained with hematoxylin-eosin, Masson's trichrome and Alcian blue pH 2.5. The level of significance to exclude the null hypothesis was 5%. RESULTS: All GE animals showed greater stability of the fracture and higher callus area. There were no significant changes in the histological study. CONCLUSION: Simvastatin accelerates the consolidation process by increasing the callus, but does not alter the histology of the newly formed bone. |
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Evaluation of simvastatin in the process of fracture healing in tibiae of ratsSimvastatinTibial fracturesRatsFracture healing OBJECTIVE: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia. METHODS: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice. In the control group was administered saline by the same route of SG. Immobilization was not used. After the sacrifice was made to limb amputation in the distal femur and conducted the clinical, radiological and histological analysis. Clinical evaluation was made as to the mobility of the fracture. Then the samples were radiographed and evaluated for callus diameter. Histological examination was performed with cuts of 5 micrometers and stained with hematoxylin-eosin, Masson's trichrome and Alcian blue pH 2.5. The level of significance to exclude the null hypothesis was 5%. RESULTS: All GE animals showed greater stability of the fracture and higher callus area. There were no significant changes in the histological study. CONCLUSION: Simvastatin accelerates the consolidation process by increasing the callus, but does not alter the histology of the newly formed bone. Sociedade Brasileira de Ortopedia e Traumatologia2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191Revista Brasileira de Ortopedia v.48 n.2 2013reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2012.10.003info:eu-repo/semantics/openAccessVasconcelos,Jose WanderleyLeite,Leopoldina Milanez da SilvaVasconcelos,Gerusa de ArrudaAraujo,Igor Marcelo Souto MaiorFerro,Letacio Santos Garciaeng2013-06-28T00:00:00Zoai:scielo:S0102-36162013000200191Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2013-06-28T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false |
dc.title.none.fl_str_mv |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
title |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
spellingShingle |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats Vasconcelos,Jose Wanderley Simvastatin Tibial fractures Rats Fracture healing |
title_short |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
title_full |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
title_fullStr |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
title_full_unstemmed |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
title_sort |
Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
author |
Vasconcelos,Jose Wanderley |
author_facet |
Vasconcelos,Jose Wanderley Leite,Leopoldina Milanez da Silva Vasconcelos,Gerusa de Arruda Araujo,Igor Marcelo Souto Maior Ferro,Letacio Santos Garcia |
author_role |
author |
author2 |
Leite,Leopoldina Milanez da Silva Vasconcelos,Gerusa de Arruda Araujo,Igor Marcelo Souto Maior Ferro,Letacio Santos Garcia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vasconcelos,Jose Wanderley Leite,Leopoldina Milanez da Silva Vasconcelos,Gerusa de Arruda Araujo,Igor Marcelo Souto Maior Ferro,Letacio Santos Garcia |
dc.subject.por.fl_str_mv |
Simvastatin Tibial fractures Rats Fracture healing |
topic |
Simvastatin Tibial fractures Rats Fracture healing |
description |
OBJECTIVE: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia. METHODS: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice. In the control group was administered saline by the same route of SG. Immobilization was not used. After the sacrifice was made to limb amputation in the distal femur and conducted the clinical, radiological and histological analysis. Clinical evaluation was made as to the mobility of the fracture. Then the samples were radiographed and evaluated for callus diameter. Histological examination was performed with cuts of 5 micrometers and stained with hematoxylin-eosin, Masson's trichrome and Alcian blue pH 2.5. The level of significance to exclude the null hypothesis was 5%. RESULTS: All GE animals showed greater stability of the fracture and higher callus area. There were no significant changes in the histological study. CONCLUSION: Simvastatin accelerates the consolidation process by increasing the callus, but does not alter the histology of the newly formed bone. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rboe.2012.10.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ortopedia v.48 n.2 2013 reponame:Revista Brasileira de Ortopedia (Online) instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) instacron:SBOT |
instname_str |
Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
instacron_str |
SBOT |
institution |
SBOT |
reponame_str |
Revista Brasileira de Ortopedia (Online) |
collection |
Revista Brasileira de Ortopedia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
repository.mail.fl_str_mv |
||rbo@sbot.org.br |
_version_ |
1752122358710140928 |