Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Ortopedia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459 |
Resumo: | ABSTRACT OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered. Demographic characteristics were evaluated and compared between patients who presented local recurrence during the clinical follow-up. RESULTS: Local recurrence was observed in 26 patients (16.7%), of whom 22 were female (84.6%). The most common site of local recurrence was the distal femur (38.4%). Eleven patients presented early recurrence, while 15 cases were diagnosed after 15 months, representing 42.3% and 57.7%, respectively. Metastases were identified in five patients (3.2%). CONCLUSION: Tumor-related factors did not show any increased incidence of local recurrence of giant cell tumors. Surgical treatment with an intralesional margin is a valid option for treating local recurrences and does not show any difference in disease-free survival in relation to other types of procedures. Clinical treatment is reserved for cases of unresectable tumors or when surgical treatment is impossible. |
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Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and OrthopedicsGiant cell tumorRecurrenceEpidemiologyABSTRACT OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered. Demographic characteristics were evaluated and compared between patients who presented local recurrence during the clinical follow-up. RESULTS: Local recurrence was observed in 26 patients (16.7%), of whom 22 were female (84.6%). The most common site of local recurrence was the distal femur (38.4%). Eleven patients presented early recurrence, while 15 cases were diagnosed after 15 months, representing 42.3% and 57.7%, respectively. Metastases were identified in five patients (3.2%). CONCLUSION: Tumor-related factors did not show any increased incidence of local recurrence of giant cell tumors. Surgical treatment with an intralesional margin is a valid option for treating local recurrences and does not show any difference in disease-free survival in relation to other types of procedures. Clinical treatment is reserved for cases of unresectable tumors or when surgical treatment is impossible.Sociedade Brasileira de Ortopedia e Traumatologia2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459Revista Brasileira de Ortopedia v.51 n.4 2016reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2016.06.004info:eu-repo/semantics/openAccessOliveira Júnior,Roberto Clayton LimaPereira,Marcelo Glauber da SilvaGarcia,Pedro Braga LinharesSantos,Patrícia Albuquerque dosCavalcanti,Amanda dos SantosMeohas,Waltereng2016-08-23T00:00:00Zoai:scielo:S0102-36162016000400459Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2016-08-23T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false |
dc.title.none.fl_str_mv |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
title |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
spellingShingle |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics Oliveira Júnior,Roberto Clayton Lima Giant cell tumor Recurrence Epidemiology |
title_short |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
title_full |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
title_fullStr |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
title_full_unstemmed |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
title_sort |
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics |
author |
Oliveira Júnior,Roberto Clayton Lima |
author_facet |
Oliveira Júnior,Roberto Clayton Lima Pereira,Marcelo Glauber da Silva Garcia,Pedro Braga Linhares Santos,Patrícia Albuquerque dos Cavalcanti,Amanda dos Santos Meohas,Walter |
author_role |
author |
author2 |
Pereira,Marcelo Glauber da Silva Garcia,Pedro Braga Linhares Santos,Patrícia Albuquerque dos Cavalcanti,Amanda dos Santos Meohas,Walter |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira Júnior,Roberto Clayton Lima Pereira,Marcelo Glauber da Silva Garcia,Pedro Braga Linhares Santos,Patrícia Albuquerque dos Cavalcanti,Amanda dos Santos Meohas,Walter |
dc.subject.por.fl_str_mv |
Giant cell tumor Recurrence Epidemiology |
topic |
Giant cell tumor Recurrence Epidemiology |
description |
ABSTRACT OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered. Demographic characteristics were evaluated and compared between patients who presented local recurrence during the clinical follow-up. RESULTS: Local recurrence was observed in 26 patients (16.7%), of whom 22 were female (84.6%). The most common site of local recurrence was the distal femur (38.4%). Eleven patients presented early recurrence, while 15 cases were diagnosed after 15 months, representing 42.3% and 57.7%, respectively. Metastases were identified in five patients (3.2%). CONCLUSION: Tumor-related factors did not show any increased incidence of local recurrence of giant cell tumors. Surgical treatment with an intralesional margin is a valid option for treating local recurrences and does not show any difference in disease-free survival in relation to other types of procedures. Clinical treatment is reserved for cases of unresectable tumors or when surgical treatment is impossible. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rboe.2016.06.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ortopedia v.51 n.4 2016 reponame:Revista Brasileira de Ortopedia (Online) instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) instacron:SBOT |
instname_str |
Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
instacron_str |
SBOT |
institution |
SBOT |
reponame_str |
Revista Brasileira de Ortopedia (Online) |
collection |
Revista Brasileira de Ortopedia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
repository.mail.fl_str_mv |
||rbo@sbot.org.br |
_version_ |
1752122360443437056 |