Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics

Detalhes bibliográficos
Autor(a) principal: Oliveira Júnior,Roberto Clayton Lima
Data de Publicação: 2016
Outros Autores: Pereira,Marcelo Glauber da Silva, Garcia,Pedro Braga Linhares, Santos,Patrícia Albuquerque dos, Cavalcanti,Amanda dos Santos, Meohas,Walter
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Ortopedia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459
Resumo: ABSTRACT OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered. Demographic characteristics were evaluated and compared between patients who presented local recurrence during the clinical follow-up. RESULTS: Local recurrence was observed in 26 patients (16.7%), of whom 22 were female (84.6%). The most common site of local recurrence was the distal femur (38.4%). Eleven patients presented early recurrence, while 15 cases were diagnosed after 15 months, representing 42.3% and 57.7%, respectively. Metastases were identified in five patients (3.2%). CONCLUSION: Tumor-related factors did not show any increased incidence of local recurrence of giant cell tumors. Surgical treatment with an intralesional margin is a valid option for treating local recurrences and does not show any difference in disease-free survival in relation to other types of procedures. Clinical treatment is reserved for cases of unresectable tumors or when surgical treatment is impossible.
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spelling Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and OrthopedicsGiant cell tumorRecurrenceEpidemiologyABSTRACT OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered. Demographic characteristics were evaluated and compared between patients who presented local recurrence during the clinical follow-up. RESULTS: Local recurrence was observed in 26 patients (16.7%), of whom 22 were female (84.6%). The most common site of local recurrence was the distal femur (38.4%). Eleven patients presented early recurrence, while 15 cases were diagnosed after 15 months, representing 42.3% and 57.7%, respectively. Metastases were identified in five patients (3.2%). CONCLUSION: Tumor-related factors did not show any increased incidence of local recurrence of giant cell tumors. Surgical treatment with an intralesional margin is a valid option for treating local recurrences and does not show any difference in disease-free survival in relation to other types of procedures. Clinical treatment is reserved for cases of unresectable tumors or when surgical treatment is impossible.Sociedade Brasileira de Ortopedia e Traumatologia2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459Revista Brasileira de Ortopedia v.51 n.4 2016reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2016.06.004info:eu-repo/semantics/openAccessOliveira Júnior,Roberto Clayton LimaPereira,Marcelo Glauber da SilvaGarcia,Pedro Braga LinharesSantos,Patrícia Albuquerque dosCavalcanti,Amanda dos SantosMeohas,Waltereng2016-08-23T00:00:00Zoai:scielo:S0102-36162016000400459Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2016-08-23T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false
dc.title.none.fl_str_mv Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
title Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
spellingShingle Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
Oliveira Júnior,Roberto Clayton Lima
Giant cell tumor
Recurrence
Epidemiology
title_short Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
title_full Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
title_fullStr Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
title_full_unstemmed Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
title_sort Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics
author Oliveira Júnior,Roberto Clayton Lima
author_facet Oliveira Júnior,Roberto Clayton Lima
Pereira,Marcelo Glauber da Silva
Garcia,Pedro Braga Linhares
Santos,Patrícia Albuquerque dos
Cavalcanti,Amanda dos Santos
Meohas,Walter
author_role author
author2 Pereira,Marcelo Glauber da Silva
Garcia,Pedro Braga Linhares
Santos,Patrícia Albuquerque dos
Cavalcanti,Amanda dos Santos
Meohas,Walter
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira Júnior,Roberto Clayton Lima
Pereira,Marcelo Glauber da Silva
Garcia,Pedro Braga Linhares
Santos,Patrícia Albuquerque dos
Cavalcanti,Amanda dos Santos
Meohas,Walter
dc.subject.por.fl_str_mv Giant cell tumor
Recurrence
Epidemiology
topic Giant cell tumor
Recurrence
Epidemiology
description ABSTRACT OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered. Demographic characteristics were evaluated and compared between patients who presented local recurrence during the clinical follow-up. RESULTS: Local recurrence was observed in 26 patients (16.7%), of whom 22 were female (84.6%). The most common site of local recurrence was the distal femur (38.4%). Eleven patients presented early recurrence, while 15 cases were diagnosed after 15 months, representing 42.3% and 57.7%, respectively. Metastases were identified in five patients (3.2%). CONCLUSION: Tumor-related factors did not show any increased incidence of local recurrence of giant cell tumors. Surgical treatment with an intralesional margin is a valid option for treating local recurrences and does not show any difference in disease-free survival in relation to other types of procedures. Clinical treatment is reserved for cases of unresectable tumors or when surgical treatment is impossible.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000400459
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.rboe.2016.06.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Ortopedia e Traumatologia
publisher.none.fl_str_mv Sociedade Brasileira de Ortopedia e Traumatologia
dc.source.none.fl_str_mv Revista Brasileira de Ortopedia v.51 n.4 2016
reponame:Revista Brasileira de Ortopedia (Online)
instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
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reponame_str Revista Brasileira de Ortopedia (Online)
collection Revista Brasileira de Ortopedia (Online)
repository.name.fl_str_mv Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
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